Impact of urban heat island effect on dengue incidence: a remote sensing approach using thermal and high-resolution optical imagery.

Dengue fever, identified by the World Health Organization as a significant global health threat, is the fastest-spreading mosquito-borne viral disease transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Annually, 100-400 million cases are reported, with over 14 million cases and 10,000 deaths in 2024 alone, highlighting the public health challenge of dengue, especially in tropical and subtropical urban areas. The Urban Heat Island (UHI) effect is a critical factor in dengue transmission, creating favorable conditions for Aedes mosquitoes.

Mutations of short tandem repeats explain abundant trait heritability in Arabidopsis.

Background: Short tandem repeat (STR) mutations are major drivers of genetic variation and deeply influence phenotypic diversity and evolution, they are often overlooked despite their significant effects.

Results: Here, we leverage mutation accumulation lines descended from Col-0 accession of Arabidopsis thaliana to assess the variation in the repeat length of STRs (STR mutation rate). We find that STR mutation rate far exceeds single nucleotide polymorphisms rates.

Deep convolutional neural network based archimedes optimization algorithm for heart disease prediction based on secured IoT enabled health care monitoring system.

The Internet of Things (IoT) is a rapidly evolving and user-friendly technology that connects everything and enables effective communication between linked things. In hospitals and other healthcare centers, healthcare monitoring systems have exploded in popularity over the last decade, and wireless healthcare monitoring devices using diverse technologies have a huge interest in several countries worldwide. The existing studies in healthcare IoT met a few shortcomings in terms of privacy, security, higher data dimensionality, higher cost, larger execution time, and so on.

p47phox: A Central Regulator of NADPH Oxidase Function and a Promising Therapeutic Target in Redox-Related Diseases.

The NADPH oxidase 2 (NOX2) complex is a critical regulator of immune homeostasis. It is utilized by phagocytic leukocytes including neutrophils, monocytes, and macrophages to generate reactive oxygen species (ROS) that drive microbe clearance and modulate inflammatory responses. Within NOX2, the essential scaffold protein p47phox plays a pivotal role in orchestrating enzyme activation and facilitating the assembly and membrane translocation of cytosolic components of the complex.

A Prospective Analysis of Risk Factors and Outcomes of Intracranial Atherosclerosis.

Introduction: Intracranial atherosclerosis (ICAS) is a progressive disease that leads to narrowing of the brain's arteries and reduced blood flow, making it a leading cause of both initial and recurrent strokes worldwide. Various contributing factors influence its development. Despite advanced neuroimaging and therapeutic interventions, the management of ICAS remains a concern.

Dispersed components drive temperature sensing and response in plants.

Plants are highly sensitive to temperature, and climate change is predicted to have negative impacts on agricultural productivity. Warming temperatures, coupled with a growing population, present a substantial challenge for food security and motivate research to understand how plants sense and respond to changes in temperature. Here, we synthesize our current understanding of temperature sensing and response in plants.

Core biological principles and tools stemming from basic Arabidopsis research.

The model plant Arabidopsis thaliana has been a cornerstone of research in plant biology, contributing transformative insights into fundamental biological processes across eukaryotes. In this vignette, we explore the role of Arabidopsis in elucidating immune mechanisms, where plant studies have informed mammalian immunity and translational regulation. We discuss how Arabidopsis-driven advancements in pangenomics and repeat expansions have reshaped our understanding of genomic variability and its implications for diseases like Friedreich's ataxia.

Coevolutionary history of predation constrains the evolvability of antibiotic resistance in prey bacteria.

Understanding how the historical contingency of biotic interactions shapes the evolvability of bacterial populations is imperative for the predictability of the eco-evolutionary dynamics of microbial communities. While microbial predators like Myxococcus xanthus influence the frequency of antibiotic-resistant bacteria in nature, the effect of adaptation to the presence of predators on the evolvability of prey bacteria to future stressors is unclear. Hence, to understand the influence of the coevolutionary history of predation on the evolvability of antibiotic resistance, we propagated variants of E.

Simple sequence repeats and their expansions: role in plant development, environmental response and adaptation.

Repetitive DNA is a feature of all organisms, ranging from archaea and plants to humans. DNA repeats can be seen both in coding and in noncoding regions of the genome. Due to the recurring nature of the sequences, simple DNA repeats tend to be more prone to errors during replication and repair, resulting in variability in their unit length.

Non-communicable disease and mental health care during the COVID-19 pandemic in South Africa: Perspectives from selected healthcare professionals and patients.

Aim: South Africa has a high burden of non-communicable diseases (NCDs) and experienced a high COVID-19 caseload, while the healthcare system was already overstretched. The aim of this study was to examine the perceptions and experiences of 1) healthcare professionals (HPs) of COVID-19 and NCD management, and the preparedness of health systems to provide NCD care, and 2) people living with NCDs (PLWNCDs) on the care they received, their mental health status and the availability of health information during the COVID-19 pandemic in South Africa.

Methods: We recruited a convenience sample of 1) HPs who worked in healthcare management, i.

Occurrence of Megamouth Shark, Megachasma pelagios (Lamniformes: Megachasmidae) in the Central Indian Ocean.

The Megamouth Shark (Megachasma pelagios), considered rare, has been observed in increased records recently, surpassing 273. The present study provides insight into the limited Indian Ocean records by reporting a specimen collected in Sakthikulangara Harbour, Kollam, Kerala, India. It highlights the need for monitoring and improved research to better understand this species in the Indian Ocean.

Super-refractory Status Epilepticus and Cerebellar Involvement Following High-Voltage Electrical Injury.

Electrocution injuries can impact any organ or system in the body. The symptoms vary widely, from immediate cardiac arrest due to high-voltage current to mild discomfort caused by low-voltage current. There are four main types of electric injuries: flash, flame, lightning, and true direct injuries.

REDD1 is a determinant of the sensitivity of renal cell carcinoma cells to autophagy inhibition that can be therapeutically exploited by targeting PIM activity.

Repurposing FDA approved drugs with off-target autophagy inhibition such as chloroquine/hydroxychloroquine (CQ, HCQ) has produced modest anticancer activity in clinical trials, due in part, to a failure to define predictive biomarkers that enable the selection of patients that best respond to this treatment strategy. We identified a new role for REDD1 as a determinant of sensitivity to autophagy inhibition in renal cell carcinoma (RCC). RNA sequencing, qRT-PCR, immunoblotting, gene silencing, knockout and overexpression studies revealed that REDD1 expression is a key regulator of cell death stimulated by autophagy inhibitors.

Warm temperature perceived at the vegetative stage affects progeny seed germination in natural accessions of Arabidopsis thaliana.

Temperatures perceived early in the life cycle of mother plants can affect the germination of the offspring seeds. In Arabidopsis thaliana, vernalisation-insensitive mutants showed altered germination response to elevated maternal temperature, hence revealing a strong genetic determinism. However, the genetic control of this maternal effect and its prevalence across natural populations remain unclear.

Effect of preoperative oral carbohydrate loading on postoperative insulin resistance, patient-perceived well-being, and surgical outcomes in elective colorectal surgery: a randomized controlled trial.

Background: Insulin resistance (IR) is one of the independent determinants influencing the length of hospital stay (LOHS) and postoperative complications in colorectal procedures. Preoperative oral carbohydrate loading (OCL) has emerged as a prospective countermeasure for IR. This study aimed to investigate the effects of preoperative carbohydrate loading on postoperative IR, inflammatory parameters, and clinical outcomes in patients undergoing elective colorectal surgery.

Targeting autophagy: a promising approach for the treatment of breast cancer brain metastases.

Patients with breast tumors that metastasize to the brain have limited treatment options and a very poor prognosis. More effective therapeutic strategies are desperately needed for this patient population. Recent evidence demonstrates that brain metastases arising from breast tumors display altered energy production that results in enhanced autophagy.

Resolving fusilier puzzles: The identity of Squamosicaesio marri and Pterocaesio flavifasciata, and a new record of Flavicaesio suevica from the Western Indian Ocean.

A phylogenetic analysis incorporating mitochondrial cox1 gene sequences of members of the family Caesionidae revealed the conspecificity of Pterocaesio flavifasciata and Squamosicaesio marri, which was also supported by the absence of any clear morphological diagnostic characters and meristic counts to separate the two species. Additionally, we provide the first record of the Suez fusilier, Flavicaesio suevica, from outside the Red Sea, based on specimens collected from the Laccadive archipelago, Western Indian Ocean. Together, these results show that the taxonomy, diversity, and distribution of members of the family Caesionidae continue to be poorly known, necessitating a comprehensive range-wide study.

Biofortification of crops with nutrients by the application of nanofertilizers for effective agriculture.

The agricultural industry is rapidly accepting daily changes and updates, and expanding to meet the basic demands of humanity. The main objective of modern agricultural practices is high profits with minimal investment, without upsetting any other form of life or abiotic factors. According to this principle, nanofertilizers are recommended for use in agriculture and are classified in different ways based on their nutritive value, functional role in the environment, chemical composition, and form of application to ensure their persistent availability in the required quantities.

Investigating Indian oil sardine aggregation events in coastal waters of the southeastern Arabian sea.

The southwest coast of India experiences frequent Indian oil sardine (IOS) nearshore aggregation events, especially in the coastal waters off Kerala. These ephemeral dense IOS aggregation events are known as "Sardine Run". To investigate the reason and provide a scientific basis for these sporadic events, satellite/model-derived physical, meteorological, and biological parameters were analysed.

SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana.

Epigenetic gene silencing induced by expanded repeats can cause diverse phenotypes ranging from severe growth defects in plants to genetic diseases such as Friedreich's ataxia in humans. The molecular mechanisms underlying repeat expansion-induced epigenetic silencing remain largely unknown. Using a plant model with a temperature-sensitive phenotype, we have previously shown that expanded repeats can induce small RNAs, which in turn can lead to epigenetic silencing through the RNA-dependent DNA methylation pathway.

Focused Exome Sequencing Gives a High Diagnostic Yield in the Indian Subcontinent.

The genetically isolated yet heterogeneous and highly consanguineous Indian population has shown a higher prevalence of rare genetic disorders. However, there is a significant socioeconomic burden for genetic testing to be accessible to the general population. In the current study, we analyzed next-generation sequencing data generated through focused exome sequencing from individuals with different phenotypic manifestations referred for genetic testing to achieve a molecular diagnosis.

The Efficacy of Yeast Supplementation on Monogastric Animal Performance-A Short Review.

Due to a continual growth in the world's population and the prohibition of antibiotics in animal production, the livestock industry faces significant challenges in the global demand for meat, eggs, and dairy products. The growing demand for organic products and the prohibition on antibiotic growth promoters (AGPs) have compelled animal nutrition experts to search for natural substitutes that include medical plants and beneficial microorganisms. Natural feed additives like probiotics are found to be more effective than AGPs in reducing the load of harmful intestinal pathogens.