Revealing the evolution of behavioral activation research trends over two decades through keyword network analysis.

Backgrounds: Behavioral activation (BA) is recognized as an evidence-based therapy for depression and other mental health conditions. Using meta-analysis and systematic literature review to analyze the research trends is helpful, but it has limitations in understanding the flow and development of BA research.

Purpose: This study aims to analyze BA research trends using keyword network analysis.

Correlation Analysis Study Between the Intensity of Counseling Friendship Network and Exercise Time Among University Taekwondo Athletics.

Background: The counseling friendship is defined as a relationship based on affection and mutual trust, wherein individuals share care, interest, and information, such as exchange emotions and concerns, thereby functioning as a social support system. Analyzing counseling friendships among university taekwondo athletes provides essential foundational data for overcoming the challenges they face and enhancing their athletic performance.

Purpose: The purpose of this study is to analyze the correlation between the intensity of counseling friendship networks and exercise time among university taekwondo athletes by using social network analysis (SNA).

Alpha-synuclein mutations mislocalize cytoplasmic p300 compromising autophagy, which is rescued by ACLY inhibition.

Triplications and certain point mutations in the SNCA gene, encoding alpha-synuclein (α-Syn), cause Parkinson's disease (PD). Here, we demonstrate that the PD-causing A53T α-Syn mutation and elevated α-Syn expression perturb acetyl-coenzyme A (CoA) and p300 biology in human neurons and in the CNS of zebrafish and mice. This dysregulation is mediated by activation of ATP-citrate lyase (ACLY), a key enzyme that generates acetyl-CoA in the cytoplasm, via two mechanisms.

Improving Gait Ability and Cognition Function through Action Observation Training in Elderly with Dementia.

BackgroundDementia is one of the most prevalent conditions among older adults.ObjectiveThis study aimed to investigate the effect of action observation training (AOT) on gait ability and cognition in older individuals with dementia.MethodsA total of 36 participants were randomly assigned to the experimental (n=18) or control (n=18) group.

Moderating role of informational support in the relationship between credible authority and parental uncertainty in developmental disabilities: a preliminary study.

Purpose: This study aims to explore the moderating role of informational support in the relationship between credible authority, representing expert information, and parental uncertainty.

Materials And Methods: Data were collected from 111 parents of children under 18 with developmental disabilities or delays via an online survey. A social network analysis was conducted to construct a professional information network based on professional information sources and satisfaction levels, with eigenvector centrality representing credible authority.

Nuclear proteasomes buffer cytoplasmic proteins during autophagy compromise.

Autophagy is a conserved pathway where cytoplasmic contents are engulfed by autophagosomes, which then fuse with lysosomes enabling their degradation. Mutations in core autophagy genes cause neurological conditions, and autophagy defects are seen in neurodegenerative diseases such as Parkinson's disease and Huntington's disease. Thus, we have sought to understand the cellular pathway perturbations that autophagy-perturbed cells are vulnerable to by seeking negative genetic interactions such as synthetic lethality in autophagy-null human cells using available data from yeast screens.

Effects of Transcranial Direct Current Stimulation on Clinical Features of Dizziness and Cortical Activation in a Patient with Vestibular Migraine.

Background: Vestibular migraine (VM) is common migraine that occurs in patients with dizziness. Vestibular rehabilitation for managing VM generally remains unclear. Recently, it has been reported that transcranial direct current stimulation (tDCS) has positive effects in alleviating dizziness.

p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome.

The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth, metabolism and autophagy. Multiple pathways modulate mTORC1 in response to nutrients. Here we describe that nucleus-cytoplasmic shuttling of p300/EP300 regulates mTORC1 activity in response to amino acid or glucose levels.

Impacts of Daily Life and Job Satisfaction on Social Participation of Persons with Visual Impairment.

Objective: This study is aimed at providing baseline data for improving the social participation of persons with visual impairment by verifying the impacts of daily life satisfaction and job satisfaction on their social participation.

Methods: This study utilized data from the 5th survey of the 2nd wave of the Panel Survey of Employment for the Disabled (PSED) provided by the Korea Employment Agency for Persons with Disabilities (KEAD). Of the 511 persons with visual impairment who participated in the panel survey, 151 people who met the inclusion criteria were selected as the research subjects.

Physiotherapy strategies for functional improvement in a child with complicated hereditary spastic paraplegia: 1-year follow-up of a case report using a changing criterion design.

Background: and Purpose: Hereditary spastic paraplegias (HSP) are a group of clinically diverse genetic disorders that share the neurologic symptom of difficulty in walking due to progressive serious muscle weakness and spasticity in the legs. This study describes a physiotherapy program for improving the functional ability of a child diagnosed with complicated HSP and reports the treatment results.

Methods: A 10-year-old boy with complicated HSP received a physiotherapy intervention that included strengthening of the leg muscles and treadmill training for 1 h per session, three to four times a week for 6 weeks.

Motor Imagery Combined With Physical Training Improves Response Inhibition in the Stop Signal Task.

Background: Motor imagery training has a similar effect to that of physical training on motor performance. The objective of this study was to investigate the short-term effectiveness of motor imagery training on response inhibition using the stop signal task (SST).

Methods: Participants were divided into a physical training group (PT,  = 17), a motor imagery training group (MIT,  = 17), and a motor imagery combined with physical training group (MIPT,  = 17).

Effects of Smartphone Overdependence and the Quality of Friendship on Depression among High School Students.

This study analyzes the effects of smartphone overdependence and the quality of friendship on depression among high school students in Korea. The study subjects were 121 high school students. Smartphone overdependence was assessed using the smartphone overdependence scale for adolescents, depression was assessed using the Korean version of the patient health questionnaire-9, and the quality of friendship was assessed using the friendship quality questionnaire.

The different autophagy degradation pathways and neurodegeneration.

The term autophagy encompasses different pathways that route cytoplasmic material to lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy, and microautophagy. Since these pathways are crucial for degradation of aggregate-prone proteins and dysfunctional organelles such as mitochondria, they help to maintain cellular homeostasis. As post-mitotic neurons cannot dilute unwanted protein and organelle accumulation by cell division, the nervous system is particularly dependent on autophagic pathways.

Vinexin contributes to autophagic decline in brain ageing across species.

Autophagic decline is considered a hallmark of ageing. The activity of this intracytoplasmic degradation pathway decreases with age in many tissues and autophagy induction ameliorates ageing in many organisms, including mice. Autophagy is a critical protective pathway in neurons and ageing is the primary risk factor for common neurodegenerative diseases.

Correlational study between online friendship network and internet game disorder among university students.

Purpose: The purpose of this study was to provide basic information about the analysis of the correlation between online friendship network and internet game disorder among university students.

Methods: Study subjects were 77 university students. For analysis of online friendship among them, social network analysis was performed and the analysis of degree, closeness, and betweenness centrality was measured.

A Backward Walking Training Program to Improve Balance and Mobility in Children with Cerebral Palsy.

Background: We studied the effects of motor tasks using backward walking training on balance and gait functions of children with cerebral palsy. This was a single-blinded, randomized controlled trial with a crossover design conducted at a single facility.

Methods: Among 12 children with cerebral palsy, the forward (FWG) ( = 6) and backward walking groups (BWG) ( = 6) underwent training three times a week for 4 weeks, 40 min a day.

Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner.

Autophagy is an essential catabolic process induced to provide cellular energy sources in response to nutrient limitation through the activation of kinases, like AMP-activated protein kinase (AMPK) and ULK1. Although glucose starvation induces autophagy, the exact mechanism underlying this signaling has yet to be elucidated. Here, we reveal a role for ULK1 in non-canonical autophagy signaling using diverse cell lines.

Ultrasound Measurement of the Transverse Abdominis, Internal Oblique, and External Oblique Muscles Associated with Forward Head Posture and Reduced Cranio-Vertebral Angle.

BACKGROUND Abnormal posture can affect the alignment of the cervical spine, which can lead to various physical problems. There are many ways to solve the problem by limiting the area around the neck to restore abnormal neck condition. However, there is a need to look at these problems from an enlarged perspective through the relationship between the cervical spine and trunk.

Lysosome positioning and mTOR activity in Lowe syndrome.

Lowe syndrome is a rare, developmental disorder caused by mutations in the phosphatase, OCRL. A study in this issue of EMBO Reports shows that OCRL is required for microtubule nucleation and that mutations in this protein lead to an inability to activate mTORC1 signaling and consequent cell proliferation in the presence of nutrients. These defects are the result of impaired microtubule-dependent lysosomal trafficking to the cell periphery and are independent of OCRL phosphatase activity.

Social interaction changes in people with intellectual disabilities through the application of equine-assisted intervention in Korea.

This study aims to provide basic information about the social interaction changes in people with intellectual disabilities through the application of equine-assisted intervention (EAI) in Korea. The subjects were 12 people with intellectual disabilities residing in a residential care facility in Korea. EAI was applied and consisted of communal activities and horseback riding.

Pelvic Belt Wearing during Exercise Improves Balance of Patients with Stroke: A Randomized, Controlled, Preliminary Trial.

Objectives: To investigate whether wearing a pelvic belt during a trunk stability exercise program positively affects balance in patients with stroke.

Materials And Methods: Twenty-four patients with stroke were randomly allocated to the experimental or control group and performed a 60-min general physical therapy and an additional 30-min trunk stability exercise (five times/week for 6 weeks). Those in the experimental and control groups performed the trunk stability exercises with and without wearing the pelvic belt, respectively.

Effect of posture control training using virtual reality program on sitting balance and trunk stability in children with cerebral palsy.

Objective: We aimed to determine whether the posture control training in the sitting posture using virtual reality (VR) training program affects sitting balance and trunk stability in children with spastic cerebral palsy (CP).

Methods: The experiment was conducted for 4 weeks by randomly allocating 20 children with CP. The experimental group (n = 10) performed balance training in the sitting position using a VR training program, and the control group (n = 10) performed arm reach training in the sitting position.

α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation.

The factors regulating cellular identity are critical for understanding the transition from health to disease and responses to therapies. Recent literature suggests that autophagy compromise may cause opposite effects in different contexts by either activating or inhibiting YAP/TAZ co-transcriptional regulators of the Hippo pathway via unrelated mechanisms. Here, we confirm that autophagy perturbation in different cell types can cause opposite responses in growth-promoting oncogenic YAP/TAZ transcriptional signalling.

Autophagy regulation by acetylation-implications for neurodegenerative diseases.

Posttranslational modifications of proteins, such as acetylation, are essential for the regulation of diverse physiological processes, including metabolism, development and aging. Autophagy is an evolutionarily conserved catabolic process that involves the highly regulated sequestration of intracytoplasmic contents in double-membrane vesicles called autophagosomes, which are subsequently degraded after fusing with lysosomes. The roles and mechanisms of acetylation in autophagy control have emerged only in the last few years.