AHP-MOORA framework for longitudinal evaluation of Pharm.D program learning outcomes: a tool for Saudi pharmacy programs accreditation and curriculum enhancement.

Introduction: As pharmacy education in Saudi Arabia progresses in accordance with Saudi Vision 2030 and international competency-based standards, the necessity for systematic evaluation of Program Learning Outcomes (PLOs) has become essential. This study aimed to establish a scalable framework for evaluating PLOs' achievement under the National Commission for Academic Accreditation and Assessment (NCAAA) criteria.

Methods: A mixed-methods methodology was utilized in a public pharmacy institution in Saudi Arabia.

Dysregulation of the leukotriene pathway in Parkinson's disease: The potential role of montelukast.

Leukotrienes (LTs) are inflammatory molecules released from leukocytes and mast cells that induce inflammation by activating leukocyte chemotaxis and vascular permeability. Notably, the LT pathway is implicated in the development and progression of different neurodegenerative diseases such as Parkinson's disease (PD). Preclinical research indicated that the LT pathway contributes to the pathophysiology of PD by inducing the development of neuroinflammation.

Job satisfaction and its correlation with pharmacists' performance and patient trust.

Background: Job satisfaction is a key factor influencing pharmacists' performance and the level of trust patients place in them. Recognizing the relationship between these elements is essential for enhancing pharmacy services, improving patient outcomes, and creating a supportive work environment in healthcare settings.

Objective: The purpose of this study is to assess how pharmacists' job satisfaction relates to their professional performance and the level of trust patients place in them.

GDF15 upregulation in Parkinson's disease: Compensatory mechanisms and causal insights.

Parkinson's disease (PD) is a prevalent long-term neurodegenerative condition resulting from the impairment of dopaminergic neurons (DNS) in the substantia nigra (SN). It is closely tied to inflammatory processes and oxidative stress, which worsen as PD neuropathology advances. Consequently, biomarkers linked to inflammation and oxidative stress may aid in diagnosing and monitoring PD progression.

A Retrospective Study on the Prevalence and Antimicrobial Susceptibility of Gram-Positive Cocci in a Pediatric Department: A Single-Center Report from Egypt.

: The rising prevalence of drug-resistant organisms presents a significant challenge to healthcare, underscoring the importance of implementing effective antimicrobial stewardship programs. The success of these programs depends on access to accurate, evidence-based data reflecting local patterns of antibiotic resistance. This study aims to assess the antimicrobial susceptibility profiles of gram-positive bacteria isolated from pediatric patients in a tertiary care hospital in Egypt.

Knowledge, Attitudes, and Practices of Community Pharmacists About Nutrition and Lifestyle Medications and Counseling in the Aseer Region of Saudi Arabia: A Cross-Sectional Study.

Introduction: Community pharmacists possess a distinctive capability to provide lifestyle and nutrition counseling; however, their integration into public health systems in Saudi Arabia is still constrained.

Aim: The objective of this study was to evaluate the knowledge, attitudes, and practices (KAP) of community pharmacists in the Aseer region about lifestyle medications and nutritional counseling.

Methods: A cross-sectional study was performed, including 257 licensed community pharmacists utilizing a self-administered, structured questionnaire consisting of six items each on KAP.

LRP1 at the crossroads of Parkinson's and Alzheimer's: Divergent roles in α-synuclein and amyloid pathology.

Parkinson's disease (PD) is the second most common neurodegenerative disease that represents the commonest movement disorder in the elderly population. PD neuropathology is due to the progressive deposition of mutant alpha synuclein (α-Syn) in the dopaminergic neurons (DNs) of the substantia nigra pars compacta (SNpc). Additionally, amyloid protein (Aβ) and tau protein, which are the hallmarks of Alzheimer's disease (AD), are also involved in PD and the development of PD-related dementia.

Berberine's paradox in Neurodegeneration: Therapeutic promise and safety challenges in Parkinson's disease.

Parkinson's disease (PD) is a chronic neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). α-Synuclein (α-Syn) is a key protein implicated in PD pathogenesis, with its structural and biophysical properties widely investigated due to their role in disease mechanisms. The presence of Lewy bodies and Lewy neurites, pathological hallmarks of PD primarily composed of aggregated α-Syn, further underscores its critical involvement.

A cross-sectional study evaluating insulin injection techniques and the impact of instructions from various healthcare professionals on insulin users in the southern region of Saudi Arabia.

Background: It is evident that proper use of the insulin injection technique (IIT) is important for optimizing the efficacy of the therapy. Despite the readily available manufacturers' instructions, healthcare professionals (HCPs) play a major role in educating patients. This study aims to investigate the knowledge, practices, and challenges faced by insulin users regarding IIT, as well as the impact of healthcare professionals' education on it.

A cross-sectional study on perceptions towards safe disposal of unused/expired medicines and its associated factors among the public in Saudi Arabia-a threat to the environment and health.

Background: The unsafe disposal of pharmaceutical waste poses significant health hazards and causes environmental pollution on a global scale. The lack of specifically authorized guidelines in Saudi Arabia for the disposal of unused medicines available at home creates an undue economic burden and potentially threatens the environment and healthcare.

Aim: The current study aimed to determine the presence, disposal practices, and perceptions of unused or expired household medicines.

Knowledge, attitude and practices of Saudi pharmacists regarding CVD risk factors and associated barriers.

Risk assessment for cardiovascular diseases (CVD) is fundamental to prevention, enabling early intervention when risks are recognized. This cross-sectional study focuses on evaluating the knowledge, attitude, practices and perceived barriers of Saudi pharmacists regarding CVD risk factors. A self-administered survey was employed to collect the responses from the participants over a period of four months.

Attitudes and Practices of Female University Students in Saudi Arabia Regarding the Cosmetic Use of Careprost (Bimatoprost) Eye Drops.

Background and objective Bimatoprost ophthalmic solution (0.03%) is used for the treatment of ocular hypertension. However, one of the side effects of this prescription is that it causes overgrowth of eyelashes, causing hypertrichosis.

Comparing knowledge, attitudes, and practices in cardiovascular disease prevention and health promotion between community and hospital pharmacists in Saudi Arabia: A cross-sectional study.

Purpose: Saudi Arabia is one of the leading nations in the world in terms of the high frequency of chronic diseases and their associated risk factors. Knowledge and awareness are crucial for pharmacists to play an active role in the prevention of cardiovascular diseases (CVD). The current study assessed the pharmacists' knowledge, attitude, and practice to determine the potential differences with respect to their respective practice settings toward CVD prevention and related health promotions.

Parasomnias and Associated Factors Among University Students: A Cross-Sectional Study in Saudi Arabia.

Background and aim Parasomnias are a group of sleep-related movements or emotions like sleepwalking, sleep talking, teeth grinding (Bruxism), nocturnal enuresis (sleep enuresis), sleep terrors (night terrors), sleep-related eating disorder (SRED), nightmare disorder, REM Sleep Behavior Disorder (RBD), and confusional arousals. Parasomnias are more common in children than in adults. This study aimed to estimate the prevalence of different parasomnias among university students in Saudi Arabia.

Knowledge, Attitudes, and Practices Related to Cervical Cancer Prevention and Screening among Female Pharmacy Students at a Public University in a Southern Region of Saudi Arabia.

Despite the availability of human papillomavirus (HPV) vaccines and screening facilities at various health centers in Saudi Arabia, the annual death rate due to cervical cancer is high. Therefore, knowledge and awareness are essential for self-care and educating others, particularly among healthcare students. The present descriptive, cross-sectional study explored female pharmacy students' knowledge, attitudes, and practices related to cervical cancer.

Targeted Drug Administration onto Cancer Cells Using Hyaluronic Acid-Quercetin-Conjugated Silver Nanoparticles.

Quercetin (QtN) displays low systemic bioavailability caused by poor water solubility and instability. Consequently, it exerts limited anticancer action in vivo. One solution to increase the anticancer efficacy of QtN is the use of appropriate functionalized nanocarriers that preferentially target and deliver the drug to the tumor location.

Patient Safety Culture in the Southern Region of Saudi Arabia: A Survey among Community Pharmacies.

Measuring patient safety culture in the community pharmacy can help with identifying areas for development. The current study is a descriptive, cross-sectional, electronic survey conducted among pharmacists working in community pharmacies located in the southern region of Saudi Arabia. The community pharmacy version of the "Pharmacy Survey on Patient Safety Culture" (PSOPSC) was used to collect data.

Revolutionizing Drug Delivery and Therapeutics: The Biomedical Applications of Conductive Polymers and Composites-Based Systems.

The first conductive polymers (CPs) were developed during the 1970s as a unique class of organic substances with properties that are electrically and optically comparable to those of inorganic semiconductors and metals while also exhibiting the desirable traits of conventional polymers. CPs have become a subject of intensive research due to their exceptional qualities, such as high mechanical and optical properties, tunable electrical characteristics, ease of synthesis and fabrication, and higher environmental stability than traditional inorganic materials. Although conducting polymers have several limitations in their pure state, coupling with other materials helps overcome these drawbacks.

Public Perception towards Vaccines as Preventive Measures against a Twindemic (Seasonal Influenza and COVID-19): A Cross-Sectional Study from the Aseer Region, Saudi Arabia.

This study aimed to evaluate Saudi Arabian public perceptions toward influenza and COVID-19 immunization during the flu season. A cross-sectional self-administered, structured, and closed-questionnaire online survey was conducted on the general public. A total of 422 people willingly participated in the survey using several social media platforms from 15 May to 15 July 2021.

Silymarin Encapsulated Liposomal Formulation: An Effective Treatment Modality against Copper Toxicity Associated Liver Dysfunction and Neurobehavioral Abnormalities in Wistar Rats.

Wilson's disease causes copper accumulation in the liver and extrahepatic organs. The available therapies aim to lower copper levels by various means. However, a potent drug that can repair the damaged liver and brain tissue is needed.

Polymeric/Dextran Wafer Dressings as Promising Long-Acting Delivery Systems for Curcumin Topical Delivery and Enhancing Wound Healing in Male Wistar Albino Rats.

Curcumin is the main active constituent in turmeric, and it is one of the biopolyphenolic compounds. A cumulative body of research supports the use of curcumin in the treatment of wounds, yet poor water solubility and lack of therapeutic dose determination hamper its use for this therapeutic purpose. This work aimed at preparing novel curcumin wafer dressings to provide a favorable environment for wound healing.

Rizatriptan-Loaded Oral Fast Dissolving Films: Design and Characterizations.

Rizatriptan (RZT) is an efficient anti-migraine drug which belongs to the class of selective 5 HT (1B/1D) serotonin receptor agonists. Nevertheless, RZT elicits several adverse effects and RZT nasal sprays have a limited half-life, requiring repeated doses that could cause patient noncompliance or harm to the nasopharynx and cilia. The current research aimed to develop orally disintegrating films (ODFs) of RZT employing maltodextrin (MTX) and pullulan (PUL) as film-forming polymers, as well as propylene glycol (PG) as a plasticizer.