Publications by authors named "Suhaib Alsayed Naeem"
The Expression of Stem Cell Marker LGR5 and Its Coexpression with Β-Catenin in Sporadic Colorectal Carcinoma and Adenoma: A Comparative Immunohistochemical Study.
Medicina (Kaunas)
June 2023
Article Synopsis
- LGR5 is a significant stem cell marker in colorectal cancer (CRC) that enhances Wnt/Β-catenin signaling, making it a potential therapeutic target.
- The study examined tissue samples from normal colon, adenomas, and CRC to analyze the expression levels of LGR5 and Β-catenin using immunohistochemical techniques.
- Findings revealed that LGR5 was absent in normal tissues but showed higher expression in adenomas and CRC, indicating its potential role in cancer development and suggesting further exploration for therapeutic applications.
Pomegranate Seeds and Peel Ethanolic Extracts Anticancer Potentials and Related Genetic, Histological, Immunohistochemical, Apoptotic and Oxidative Stress Profiles: In vitro Study.
J Exp Pharmacol
April 2023
Introduction: Owing to their great quantity of hydrolyzable anthocyanins and tannins, the peel and seeds of pomegranate are edible and possess potent anti-oxidant and anti-inflammatory characteristics. This work aims to trace the pomegranate seed and peel ethanolic extracts' anticancer activity against liver cancer cell line, namely HepG2 and related histopathological, immunohistochemical, genetic and oxidative stress profile.
Methods: In vitro study for both seed and peel extract showed the prevalence of phenols, polyphenols and acids, those have anti-proliferative potential against liver cancer cell line (HepG2) with 50% inhibitory concentration (IC50) of seed significantly reduced that of peel.
Introduction: Although widespread, BCC is still relatively poorly understood in regards to pathogenesis and prognosis, particularly the lesions formed on anatomical sites away from sun exposure. With the aim of deepening our understanding of the pathogenesis and clinico-pathological correlations of BCCs, we conducted this study.
Methods: Tissue blocks and data of 52 Egyptian patients diagnosed with BCC were retrieved for clinical information and inclusion criteria, then re-examined histologically; p16 immunostaining was carried out and evaluated for analysis and comparison between the two groups, i.