Photoinduced Plasmon Electron Transfer-based Bioorthogonal Cleavage Reaction for Precision Tumor Therapy.

Photocatalytic reactions have been harnessed to develop advanced medical solutions for transformative cancer therapy. However, their limited catalytic activities within biological environments must be enhanced to maximize their potential in practical applications. Here, a spatiotemporally controllable photocatalytic cancer therapy is reported through the photoinduced plasmon electron transfer (PiPET)-based biorthogonal cleavage reaction of a pro-photosensitizer, allyl carbamate-conjugated methylene blue (MB).

Understanding the impact of antenatal corticosteroids via placenta and fetal lung microphysiological analysis platform (MAP) on a chip.

Antenatal corticosteroids are recommended for preterm births to enhance lung maturity; however, the guidelines are based on limited studies. Here, we present a placenta-fetal lung microphysiological analysis platform (MAP) to study how corticosteroids promote fetal lung maturation and determine their optimal concentration with minimal side effects. We create trophoblast-capillary-pneumocyte MAP on chips to analyze the transport of corticosteroids from mother to fetus through the placenta.

MOF-Based Single-Atom and Metal Cluster Catalysts by Room-Temperature Synthesis for Tumor Therapy.

Metal-organic frameworks (MOFs) are widely used as substrates for creating single-atom catalysts due to their abundance of ligands, facilitating enzyme-like activity for biomedical applications. However, the high-temperature calcination process for single-atom catalysts limits economical, efficient, and large-scale synthesis. Here, a simple room-temperature synthesis of MOF-based single-atom and metal cluster catalysts is presented for tumor therapy.

Optically tunable catalytic cancer therapy using enzyme-like chiral plasmonic nanoparticles.

Cascade enzymatic reactions in living organisms are fundamental reaction mechanisms in coordinating various complex biochemical processes such as metabolism, signal transduction, and gene regulation. Many studies have attempted to mimic cascade reactions using nanoparticles with enzyme-like activity; however, precisely tuning each reaction within complex networks to enhance the catalytic activity remains challenging. Here, we present enzyme-like chiral plasmonic nanoparticles for optically tunable catalytic cancer therapy.

Halide-Diffusion-Assisted Perovskite Lamination Process for Semitransparent Perovskite Solar Cells.

Semitransparent perovskite solar cells (PSCs) efficiently absorb light from both front and rear sides under illumination, and hence, PSCs have the potential for use in applications requiring bifacial or tandem solar cells. A facile method to fabricate semitransparent PSCs involves preparing a perovskite (PVSK) film on two transparent substrates and then laminating the substrates together. However, realizing high-performance laminated semitransparent PSCs is challenging because the imperfect contact at the PVSK interlayer results in void formation and partial degradation of PVSK.

Biological Cavity Quantum Electrodynamics via Self-Aligned Nanoring Doublets: QED-SANDs.

Quantum mechanics is applied to create numerous electronic devices, including lasers, electron microscopes, magnetic resonance imaging, and quantum information technology. However, the practical realization of cavity quantum electrodynamics (QED) in various applications is limited due to the demanding conditions required for achieving strong coupling between an optical cavity and excitonic matter. Here, we present biological cavity QED with self-aligned nanoring doublets: QED-SANDs, which exhibit robust room-temperature strong coupling with a biomolecular emitter, chlorophyll-.

Geohelminths: Use in the Treatment of Selected Human Diseases.

Research on the therapeutic use of parasites has been ongoing since the development of the "hygiene hypothesis". Parasites can stimulate the Th2-dependent response and suppress the Th1-dependent response, which is intensified in many diseases, especially allergic and autoinflammatory ones. In this review, we present the types of parasites used in helminth therapy and the range of diseases in which they may be useful.

Nanoplasmonic biosensors for environmental sustainability and human health.

Monitoring the health conditions of the environment and humans is essential for ensuring human well-being, promoting global health, and achieving sustainability. Innovative biosensors are crucial in accurately monitoring health conditions, uncovering the hidden connections between the environment and human well-being, and understanding how environmental factors trigger autoimmune diseases, neurodegenerative diseases, and infectious diseases. This review evaluates the use of nanoplasmonic biosensors that can monitor environmental health and human diseases according to target analytes of different sizes and scales, providing valuable insights for preventive medicine.

ANTIBACTERIAL EFFECT OF CRATAEGUS PINNATIFIDA EXTRACT AGAINST ENTROCOCCUS FAECALIS A ROOT CANAL DISEASE-CAUSING BACTERIA.

Studies have substantiated the anti-inflammatory and anti-thrombotic effects of (C. pinnatifida); however, research on its antibacterial activity using organic solvent remains limited. Therefore, in this study, we aimed to validate the antibacterial activity of C.

GROWTH INHIBITORY EFFECT OF HOUTTUYNIA CORDATA EXTRACT ON STREPTOCOCCUS MUTANS.

Houttuynia cordata is an herbal plant distributed throughout Asia. H. cordata has many bioactive properties, including antibacterial properties.

Anisotropic Plasmonic Gold Nanorod-Indocyanine Green@Reduced Graphene Oxide-Doxorubicin Nanohybrids for Image-Guided Enhanced Tumor Theranostics.

The unique physicochemical and localized surface plasmon resonance assets of gold nanorods (GNRs) have offered combined cancer treatments with real-time diagnosis by integrating diverse theragnostic modalities into a single nanoplatform. In this work, a unique multifunctional nanohybrid material based on GNRs was designed for and tumor imaging along with synergistic and combinatorial therapy of tumor. The hybrid material with size less than 100 nm was achieved by embedding indocyanine green (ICG) on mesoporous silica-coated GNRs with further wrapping of reduced graphene oxide (rGO) and then attached with doxorubicin (DOX) and polyethylene glycol.

Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy.

Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core.

Cudraxanthone D Regulates Epithelial-Mesenchymal Transition by Autophagy Inhibition in Oral Squamous Cell Carcinoma Cell Lines.

Cudraxanthone D (CD), derived from the root bark of , is a natural xanthone compound. However, the biological activity of CD in terms of human metabolism has been barely reported to date. Autophagy is known as a self-degradation process related to cancer cell viability and metastasis.

Crosstalk between Fisetin-induced Apoptosis and Autophagy in Human Oral Squamous Cell Carcinoma.

Fisetin (3,3-,4-,7-tetrahydroxyflavone), a naturally occurring flavonoid, has antioxidant, anti-inflammatory, and anticancer effects. Oral squamous cell carcinoma (OSCC) has a 5-year survival rate lower than that of most other carcinomas, and can create functional and aesthetic problems for the patient. New therapies for OSCC are necessary, and treatment using plant-derived natural substances has recently become a trend.

Synergistic Nanozymetic Activity of Hybrid Gold Bipyramid-Molybdenum Disulfide Core@Shell Nanostructures for Two-Photon Imaging and Anticancer Therapy.

In recent years, the concept of combined therapy using gold hybrid nanomaterials has been broadly adopted to pioneer new anticancer treatments. However, their synergistic anticancer effects have yet to be thoroughly investigated. Herein,a hybrid gold nanobipyramid nanostructure coated with molybdenum disulfide (MoS) semiconductor (AuNBPs@MoS) was proposed as a smart nanozyme for anticancer therapy and two-photon bioimaging.

Cordycepin Accelerates Osteoblast Mineralization and Attenuates Osteoclast Differentiation In Vitro.

Bone homeostasis destruction is triggered by the uncontrolled activity of osteoblasts and osteoclasts. Targeting both the regulation of bone formation and resorption is a promising strategy for treating bone disorders. Cordycepin is a major component of Chinese caterpillar fungus .

Induction of Apoptosis and Inhibition of Epithelial Mesenchymal Transition by -Mangostin in MG-63 Cell Lines.

Osteosarcoma is the most common bone primary malignant tumor and nearly 30% of patients still die from osteosarcoma due to metastasis or recurrence. Thus, it is necessary to develop effective new chemotherapeutic agents for osteosarcoma treatment. -Mangostin is a xanthone derivative shown to have antioxidant and anticarcinogen properties.

Delphinidin induces apoptosis and inhibits epithelial-to-mesenchymal transition via the ERK/p38 MAPK-signaling pathway in human osteosarcoma cell lines.

Delphinidin is major anthocyanidin that is extracted from many pigmented fruits and vegetables. This substance has anti-oxidant, anti-inflammatory, anti-angiogenic, and anti-cancer properties. In addition, delphinidin strongly suppresses the migration and invasion of various cancer cells during tumorigenesis.

Cytoprotective effect of flavonoid-induced autophagy on bisphosphonate mediated cell death in osteoblast.

With rapid economic growth and further developments in medical science, the entry into the aging population is currently increasing, as is the number of patients with metabolic diseases, such as hypertension, hyperlipidemia, heart disease, and diabetes. The current treatments for metabolic bone diseases, which are also on the rise, cause negative side effects. Bisphosphonates, which are used to treat osteoporosis, inhibit the bone resorption ability of osteoclasts and during prolonged administration, cause bisphosphonate-related osteonecrosis of the jaw (BRONJ).

Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy.

Background: In oxidative stress, reactive oxygen species (ROS) production contributes to cellular dysfunction and initiates the apoptotic cascade. Autophagy is considered the mechanism that decreases ROS concentration and oxidative damage. Propofol shows antioxidant properties, but the mechanisms underlying the effect of propofol preconditioning (PPC) on oxidative injury remain unclear.

Propofol protects human keratinocytes from oxidative stress via autophagy expression.

Background: The skin consists of tightly connected keratinocytes, and prevents extensive water loss while simultaneously protecting against the entry of microbial pathogens. Excessive cellular levels of reactive oxygen species can induce cell apoptosis and also damage skin integrity. Propofol (2,6-diisopropylphenol) has antioxidant properties.

XIAP inhibitor embelin induces autophagic and apoptotic cell death in human oral squamous cell carcinoma cells.

Embelin is an active ingredient of traditional herbal remedies for cancer and other diseases. Recently, it has been suggested that autophagy may play an important role in cancer therapy. However, little data are available regarding the role of autophagy in oral cancers.

α-Mangostin Induces Apoptosis and Cell Cycle Arrest in Oral Squamous Cell Carcinoma Cell.

Mangosteen has long been used as a traditional medicine and is known to have antibacterial, antioxidant, and anticancer effects. Although the effects of α-mangostin, a natural compound extracted from the pericarp of mangosteen, have been investigated in many studies, there is limited data on the effects of the compound in human oral squamous cell carcinoma (OSCC). In this study, α-mangostin was assessed as a potential anticancer agent against human OSCC cells.