ECCO-ESGAR-ESP-IBUS Guideline on Diagnostics and Monitoring of Patients with Inflammatory Bowel Disease: Part 1.

The current consensus guideline offers a comprehensive and practical guidance on the diagnostic and monitoring of patients with inflammatory bowel disease (IBD). It provides recommendations on requirements for initial diagnosis, detection of complications, the use of monitoring tools in patients with IBD and diagnostics in specific situations, such as pregnancy, postoperatively and for cancer surveillance. The guideline is a joint project of the European Crohn's and Colitis Organization (ECCO), the European Society of Gastrointestinal and Abdominal Radiology, the European Society of Pathology, and the International Bowel Ultrasonography Group under the leadership of ECCO.

The EXTENT Study: Results From an International Expert Delphi Consensus to Define Ultrasonographic Parameters for Measuring Bowel Damage in Crohn's Disease.

Background & Aims: A primary aim in managing Crohn's disease (CD) is preventing bowel damage. The Lémann index (LI) quantifies structural bowel damage using magnetic resonance enterography (MRE) or computed tomography enterography (CTE) and, for colonic CD, colonoscopy. Intestinal ultrasonography (IUS) provides a noninvasive imaging alternative, although its role in LI assessment remains unexplored.

Oxygen-Enhanced R2* Weighted MRI and Diffusion Weighted MRI of Head and Neck Squamous Cell Cancer Lymph Nodes in Prediction of 2-Year Outcome Following Chemoradiotherapy.

Background: We evaluated the utility of HNSCC LN R2* relaxation times to infer the oxygenation status of LN non-invasively at baseline and when breathing air and 100% oxygen to predict chemoradiotherapeutic locoregional response at 2 years. Hypoxia within LNs has been associated with poorer outcomes following CRT. Deoxyhaemoglobin decreases MRI transverse relaxation time (T2*) (lengthening inverse, R2*).

Enhancing Activation of DO for Highly Efficient Deuteration Using an Fe-P Pair-Site Catalyst.

Deuterated amine derivatives have emerged as valuable compounds in medicinal chemistry and materials science due to their enhanced metabolic stability and unique physicochemical properties, emphasizing the need for cost-effective and efficient deuteration catalysts; yet this topic has rarely been explored. In this work, we present an atomically dispersed Fe-P pair-site catalyst with high catalytic efficiency and regioselectivity in the deuteration of arenes and heteroarenes using DO as the deuterated source. Remarkably, these metal-nonmetal Fe-P catalytic pairs with low Fe loading (0.

Expert Position Statement: Defining the Role of Intestinal Ultrasound in Assessing Constipation and Faecal Loading.

Background: Intestinal ultrasound has been proposed as a tool to assess non-inflammatory functional gastrointestinal disorders, including constipation and faecal loading. However, well-defined sonographic criteria for these conditions are currently lacking.

Aim: To identify and establish specific sonographic parameters that could be used to assess constipation and faecal loading with intestinal ultrasound.

British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025.

In response to recent advancements in inflammatory bowel disease (IBD) management, the British Society of Gastroenterology (BSG) Clinical Services and Standards Committee (CSSC) has commissioned the BSG IBD section to update its guidelines, last revised in 2019. These updated guidelines aim to complement the IBD standards and promote the use of the national primary care diagnostic pathway for lower gastrointestinal symptoms to enhance diagnostic accuracy and timeliness. Formulated through a systematic and transparent process, this document reflects a consensus of best practices based on current evidence.

Dynamic Active Site Evolution in Lanthanum-Based Catalysts Dictates Ethane Chlorination Pathways.

Radical-mediated chlorination of ethane presents a low-carbon alternative for polyvinyl chloride (PVC) synthesis, yet selectivity toward 1,2-dichloroethane remains challenged by uncontrolled over-chlorination. Lanthanum oxychloride (LaOCl) has emerged as a promising catalyst, but its structural dynamics under Cl-rich conditions and the origin of selectivity loss remain elusive. Here, we integrate advanced spectroscopic techniques with theoretical calculations to address this knowledge gap.

Parcel-Level Housing Conditions and Pediatric Asthma Hospital Utilization.

Objective: Pediatric hospital encounters related to asthma have been linked to failed housing inspections, but evidence at the individual- and parcel-level is absent. Our objective was to examine the impact of housing code violations on pediatric asthma exacerbations.

Methods: We conducted a retrospective cohort study based on electronic health records at Cincinnati Children's Hospital Medical Center in Hamilton County, Ohio, between July 2016 and July 2022.

ESR Essentials: diagnosis and assessment of treatment response in patients with luminal Crohn's disease-practice recommendations by the European Society of Gastrointestinal and Abdominal Radiology.

The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) presents an ESR Essentials review article on Crohn's disease (CD) diagnosis and treatment response assessment. The focus is on luminal disease, particularly in the small bowel, and to a lesser degree, the colon. Magnetic Resonance Enterography (MRE) and ultrasound are typically the first-line radiological investigations for known or suspected luminal CD.

Role of Noninvasive Imaging in the Diagnosis and Management of Patients With Suspected and Established Inflammatory Bowel Disease.

In a treat-to-target era, objective disease assessment in inflammatory bowel disease has become increasingly important. For many years, endoscopy has been generally accepted as the gold standard for evaluating the bowel mucosa, additionally facilitating biopsy. However, noninvasive disease assessment is now increasingly demanded, and cross-sectional imaging techniques, as well as video capsule endoscopy, have markedly improved.

Quantified motility assessment in paediatric inflammatory bowel disease: a multi-reader study.

Background: Quantitative bowel motility in inflammatory bowel disease using magnetic resonance enterography (MRE) shows promise as a biomarker of disease activity against histopathological and biochemical markers of inflammation when used by experienced readers in a research setting.

Objective: The aim of this study was to test multi-reader agreement in quantified bowel motility by non-experienced readers.

Materials And Methods: A single-centre, retrospective search included all patients <18 years with paediatric inflammatory bowel disease and more than one MRE between 2012-2022.

Inter- and intra-observer variability of software quantified bowel motility measurements of small bowel Crohn's disease: findings from the MOTILITY trial.

Objectives: Motility magnetic resonance imaging (mMRI) is a potential marker of disease activity of small bowel Crohn's disease (SBCD), but there is limited data on its reproducibility. We assessed inter- and intra-observer agreement of small bowel motility as part of a prospective multicentre trial investigating whether mMRI can predict longer-term response to biologic therapy in active, non-stricturing SB-CD (MOTILITY Trial).

Methods: 297 segmental small bowel motility scores from 104 SBCD patients (mean age 38.

Magnetic resonance enterography to predict subsequent disabling Crohn's disease in newly diagnosed patients (METRIC-EF)-multivariable prediction model, multicentre diagnostic inception cohort.

Objectives: Magnetic resonance enterography (MRE) is a first-line investigation to diagnose Crohn's disease (CD), but its role for prognostication is unknown. Accordingly, we assessed the predictive ability of prognostic models including MRE scores (MRE Global Score (MEGS), simplified MR Index of Activity (sMARIA), and Lémann index (LI)) against models using clinical predictors alone for the development of modified Beaugerie disabling CD (MBDD) within 5 years of diagnosis.

Methods: This was a multicentre, diagnostic inception cohort of patients with newly diagnosed CD across 9 UK hospitals, followed for 4 years or more.

Studies on the Reactions of Lactone Intermediates Derived from Levulinic Acid: Telescoped Routes to Higher Levulinate Ester Biofuels.

The development of efficient strategies for the synthesis of levulinate esters is of significant current interest due to their potential as biofuels and fuel additives. Herein, we report a novel strategy to access levulinate esters derived from higher alcohols directly from levulinic acid through the in situ generation of lactone intermediates employing commercial heterogeneous catalysts, such as Amberlyst-15. This strategy employs a telescoped approach in which the lactonization/ring-opening reactions are combined into an operationally simple one-pot procedure.

Drug Addiction: Failure, Feast and Phoenix.

This article offers a unique interdisciplinary theoretical examination of the stigmatisation of 'drug addicts' and its impacts on health and wellbeing. In the present conjuncture, drug addiction has become a metaphor for a 'wasted' life. The stigmatisation of addicts creates artificial monsters.

Evaluation of prognostic models to improve prediction of metastasis in patients following potentially curative treatment for primary colorectal cancer: the PROSPECT trial.

Background: Despite apparently curative treatment, many patients with colorectal cancer develop subsequent metastatic disease. Current prognostic models are criticised because they are based on standard staging and omit novel biomarkers. Improved prognostication is an unmet need.

MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn's disease.

Objectives: Altered body fat and muscle mass in Crohn's disease (CD) have been linked to adverse disease course and outcomes. Prediction of treatment response or remission (RoR) of small bowel CD (SBCD) to biologic therapy remains challenging. We aimed to establish the prognostic value of body composition parameters measured using MR enterography (MRE) for RoR at 1 year in patients with SBCD commencing biologic therapy.

CT Colonography for Colorectal Cancer Prevention and Detection: Integration Into Clinical Practice, From the Special Series on Screening.

CT colonography (CTC) is a CT examination, performed with low dose and typically without IV contrast media, optimized to detect colorectal polyps and cancer. Despite extensive supporting data, CTC has had variable acceptance and use over the past two decades, particularly for a main indication of colorectal cancer screening. CTC is now at an inflection point after the approval in 2025 by CMS for reimbursement of CTC performed for colorectal cancer screening.

A British Society of Gastrointestinal and Abdominal Radiology multi-centre audit of imaging investigations in inflammatory bowel disease.

Objectives: To evaluate current UK practice for inflammatory bowel disease (IBD) imaging against recommendations from published international literature.

Methods: A retrospective multi-centre audit was undertaken evaluating imaging modalities, protocols, and pathways used to investigate IBD both in outpatient and inpatient settings during January-December 2022. Reporting practices and training provisions were also recorded.

Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn's Disease Commencing Biological Therapy: The Motility Study.

Background: Small bowel Crohn's disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motility magnetic resonance imaging (mMRI) is superior to CRP and fecal calprotectin (FC) for the prediction of RoR at 1 year in patients commencing biologics for SBCD.