Publications by authors named "Struan Gray"
Article Synopsis
- Metformin, an anti-diabetic drug, is being studied for its potential anticancer effects, particularly in metastatic hormone-sensitive prostate cancer, where it may also help counteract issues related to androgen-deprivation therapy (ADT).
- The STAMPEDE trial involved patients with high-risk prostate cancer across the UK and Switzerland, comparing standard treatment with and without metformin for non-diabetic patients who were in good health.
- Patients were randomly assigned to receive either standard care or standard care plus metformin, with the main goal of assessing overall survival in those treated with the additional medication.
Article Synopsis
- Androgen-deprivation therapy (ADT) is the standard treatment for metastatic prostate cancer but comes with notable side effects.
- The review emphasizes methods to reduce the adverse effects of ADT and looks at alternative treatments for prostate cancer.
- By implementing effective strategies to manage side effects and exploring other treatment options, healthcare providers can improve patients' quality of life during ADT.
Context: The addition of androgen receptor signalling inhibitors (ARSIs) to standard androgen deprivation therapy (ADT) has improved survival outcomes in patients with advanced prostate cancer (PCa). Advanced PCa patients have a higher incidence of osteoporosis, compounded by rapid bone density loss upon commencement of ADT resulting in an increased fracture risk. The effect of treatment intensification with ARSIs on fall and fracture risk is unclear.
View Article and Find Full Text PDFWe present a noninvasive optical method to determine the local strain in individual semiconductor nanowires. InP nanowires were intentionally bent with an atomic force microscope and variations in the optical phonon frequency along the wires were mapped using Raman spectroscopy. Sections of the nanowires with a high curvature showed significantly broadened phonon lines.
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