Publications by authors named "Stephane Lemasson"
Inhaled bronchodilator administration during mechanical ventilation: how to optimize it, and for which clinical benefit?
J Aerosol Med Pulm Drug Deliv
March 2008
Bronchodilators are frequently used in ICU patients, and are the most common medications administered by inhalation during mechanical ventilation. The amount of bronchodilator that deposits at its site of action depends on the amount of drug, inhaled mass, deposited mass, and particle size distribution. Mechanical ventilation challenges both inhaled mass and lung deposition by specific features, such as a ventilatory circuit, an endotracheal tube, and ventilator settings.
View Article and Find Full Text PDFViscoelastic properties of lungs and thoracic wall of anesthetized mechanically ventilated piglets.
Vet Anaesth Analg
September 2007
Article Synopsis
- The study aimed to investigate the viscoelastic properties of piglet lungs and thoracic walls, using a controlled experimental approach with six 30 kg piglets undergoing tracheotomy and mechanical ventilation.
- Acute lung injury was induced to measure changes in lung and thoracic wall tissue resistance, using a rapid airway occlusion technique to assess how different pressures affected viscoelastic properties.
- Results showed a significant increase in lung resistance and time constant during acute lung injury, indicating altered mechanical properties, with varying effects observed under zero end-expiratory pressure and positive end-expiratory pressure conditions.
Does gas exchange response to prone position predict mortality in hypoxemic acute respiratory failure?
Intensive Care Med
December 2006
Objective: To determine whether gas exchange response to a first prone position session can predict patient outcome in hypoxemic acute respiratory failure.
Methods: Data from a previous multicenter randomized controlled trial were retrospectively analyzed for relationship between PaO(2)/FIO(2) ratio and PaCO(2) changes during the first 8-h prone position session to day 28 mortality rate; 370 prone position sessions were analyzed. Arterial blood gas was measured in supine position before proning and in prone position at the end of the session.
Objective: To assess a sigmoidal equation for describing airway closure.
Design: Experimental study.
Setting: University laboratory.
Background: During acute ventilatory failure in patients with chronic obstructive pulmonary disease (COPD), applying external positive end-expiratory pressure (PEEPe) will reopen small airways and, thus, may enhance peripheral deposition as well as the physiological effects of inhaled beta-2 agonists.
Objective: To investigate the efficacy of inhaled fenoterol applied by zero end-expiratory pressure (ZEEPe) or PEEPe.
Methods: Ten patients with COPD who were intubated and mechanically ventilated received fenoterol (10 mg/4 mL) via the ventilator using a jet nebulizer for 30 min on ZEEPe and PEEPe set at 80% of the total PEEP in a random order.
Context: A recent trial showed that placing patients with acute lung injury in the prone position did not increase survival; however, whether those results hold true for patients with hypoxemic acute respiratory failure (ARF) is unclear.
Objective: To determine whether prone positioning improves mortality in ARF patients.
Design, Setting, And Patients: Prospective, unblinded, multicenter controlled trial of 791 ARF patients in 21 general intensive care units in France using concealed randomization conducted from December 14, 1998, through December 31, 2002.
Objective: To study the cardiorespiratory effects of inspiratory flow rate and waveform in COPD patients.
Design: Prospective physiological investigation with randomized allocations of experimental conditions.
Setting: A 14-bed medical ICU in a 1000-bed university hospital.