Publications by authors named "Stephane Laurent"
Large Tumor Suppressor kinases LATS1 and 2 (LATS1/2) are serine/threonine kinases and core regulators of the Hippo-YAP pathway. Inhibition of LATS1/2 promotes nuclear translocation of nonphosphorylated YAP, thereby initiating a downstream cascade promoting cell proliferation. We set out to investigate the potential of LATS inhibition as a therapeutic approach to enhance tissue regeneration and hereby report a structure-guided optimization of screening hit for potency, binding efficiency, and physicochemical properties, leading to a highly selective, cellularly active, and orally available tool compound (NIBR-LTSi) that demonstrated target engagement and in vivo YAP target gene activation in rodents.
View Article and Find Full Text PDFPurpose: The goal was to gain insight into the effects of hearing loss and hearing aids (HAs) on the perception of "natural sounds" and their importance in daily life by documenting the opinions of hearing care professionals (HCPs).
Method: A questionnaire was designed where HCPs were asked to rate their patients' perception of natural sounds before and after receiving an HA. The online survey was conducted with 301 HCPs in France.
Vascular ageing manifestations and hypertension in the community.
Am J Prev Cardiol
March 2025
Objective: To investigate the association between joint manifestations of vascular ageing (VA) and hypertension.
Methods: We used baseline (2008-2012) and follow-up data (up to 2024) from the Paris Prospective Study III, a French cohort of 10,157 participants. Prevalent and incident hypertension were determined at baseline (blood pressure ≥140/90 mmHg or on medication) and at 2, 4, 6, 8 and 10 years of follow-up (self-reported antihypertensive treatment).
Article Synopsis
- The YAP/Hippo pathway regulates organ growth and helps maintain stem cell function, with LATS kinases playing a critical role by inactivating YAP.
- A new small-molecule inhibitor, NIBR-LTSi, has been developed that selectively targets LATS kinases, activating YAP signaling and promoting tissue regeneration in laboratory settings.
- While NIBR-LTSi shows promise by enhancing liver regeneration and supporting stem cell characteristics, prolonged use may lead to excessive cell proliferation and dedifferentiation, which could limit its therapeutic benefits.
Article Synopsis
- The text highlights the critical role of elastic properties in conductance arteries for maintaining proper blood flow and their dysfunction's link to aging and cardiovascular diseases.
- It reviews important factors contributing to arterial stiffness, focusing on vascular smooth muscle cell behavior and various biological mechanisms influencing this condition.
- The article emphasizes recent clinical studies that are reshaping treatment approaches for arterial stiffness, advocating for personalized strategies based on individual cardiovascular risks.
Article Synopsis
- Arterial stiffness, measured by pulse wave velocity (PWV), is a key indicator of cardiovascular risk, but new devices for measuring PWV have varying accuracy, emphasizing the need for validation.
- A Delphi technique was used to create a shared approach for validating noninvasive PWV measurement devices, involving global scientific societies focused on arterial stiffness.
- The resulting recommendations aim to standardize the validation process for these devices, enhancing their reliability and practical use in clinical settings for assessing cardiovascular health in hypertensive individuals.
Article Synopsis
- Cochlear implants (CIs) help individuals with severe-to-profound hearing loss recognize speech, but understanding speech in noisy environments is still difficult; this study investigates whether using a tonotopic map for CI fitting can enhance speech perception in both quiet and noisy settings.
- The research was conducted among 26 new CI users in a double-blind, randomized, cross-over design over 6 months, where participants were assigned different fitting methods and subsequently evaluated on their speech recognition abilities.
- Results indicated that participants fitted with the tonotopic map performed significantly better in recognizing speech in noise across various signal-to-noise ratios, highlighting the potential benefits of this fitting method for improving auditory experiences in challenging listening environments.
2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension: Endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA).
J Hypertens
December 2023
Article Synopsis
- The text lists a diverse group of individuals from various countries involved in a specific academic or professional field, highlighting the international collaboration.
- The names represent a wide range of nationalities, including participants from continents such as North America, Europe, Asia, and South America.
- The purpose of this assembly may be related to research, a conference, or a project aiming to address global issues in their field of expertise.
Article Synopsis
- Arterial stiffness, an indicator of cardiovascular risk, comprises a BP-dependent elastic behavior and long-term structural changes due to various risk factors, which can be assessed using the QKD method through 24-hour monitoring.
- This study hypothesizes that QKD measured at 100 mmHg SBP and 60 bpm heart rate is unaffected by 24-hour SBP levels in normotensive and treated hypertensive individuals, but shows a weak correlation in untreated hypertensive patients.
- Results indicated that QKD100-60 was not significantly related to 24-hour SBP in normal and treated hypertensive groups, while showing a weak but noteworthy relationship in untreated hypertensives, suggesting QKD's potential to improve risk assessment in
Article Synopsis
- - Microcirculation and macrocirculation are interlinked in hypertension, where damage to small arteries leads to increased peripheral resistance and high blood pressure, resulting in large artery stiffening.
- - This stiffening raises central blood pressures and contributes to complications in the heart, brain, and kidneys, creating a feedback loop that worsens hypertension and its effects.
- - Certain medications, like ACE inhibitors and calcium channel blockers, can disrupt this cycle more effectively than β-blockers or diuretics, helping to reduce arterial stiffness and prevent related complications.
Article Synopsis
- The study examined the link between obstructive sleep apnea (OSA) and cardiovascular disease, focusing on vascular aging in high versus low-risk patients for OSA.
- Two community-based studies (PPS3 and Maastricht Study) found that around 17-24% of participants were at high risk for OSA, as determined by the Berlin questionnaire.
- Results showed that those at high risk had significantly greater carotid artery measurements indicating accelerated vascular aging, which may contribute to cardiovascular disease risk.
The EBI2 receptor regulates the immune system and is expressed in various immune cells including B and T lymphocytes. It is also expressed in astrocytes in the central nervous system (CNS) where it regulates pro-inflammatory cytokine release, cell migration and protects from chemically induced demyelination. Its signaling and expression are implicated in various diseases including multiple sclerosis, where its expression is increased in infiltrating immune cells in the white matter lesions.
View Article and Find Full Text PDFHuman physiology is regulated by endogenous signalling compounds, including fatty acid amides (FAAs), chemical mimics of which are made by bacteria. The molecules produced by human-associated microbes are difficult to identify because they may only be made in a local niche or they require a substrate sourced from the host, diet or other microbes. We identified a set of uncharacterized gene clusters in metagenomics data from the human gut microbiome.
View Article and Find Full Text PDFArticle Synopsis
- The main topic of the text focuses on [insert main idea or theme].
- It discusses [key points or arguments made in the text], highlighting [important findings or insights].
- The conclusion or implications drawn suggest that [summarize the conclusion or the significance of the text]. Feel free to fill in the details based on the content of your text!
Hypertension prevalence increases with age. Age and high blood pressure are the two main determinants of arterial stiffness. In elderly hypertensives, large arteries stiffen and systolic and pulse pressures increase, due to wave reflections.
View Article and Find Full Text PDFArticle Synopsis
- * Results showed significant improvements in test scores for both groups, with the VR group showing higher mean score increases (21.1 points) compared to the traditional group (6.9 points) and no significant score difference after VR training.
- * Satisfaction and self-confidence ratings were notably higher for the VR group, with 100% reporting good satisfaction compared to 74% in the traditional group, indicating that VR training could be a more effective method for audiology education.
Article Synopsis
- - Pulse wave velocity can indicate early vascular aging and help identify individuals with "supernormal" vascular aging, defined by a significant difference between chronological and vascular age (Δ-age).
- - In a study of 2,642 individuals over a 6.6-year follow-up, those with supernormal vascular aging had a lower risk of cardiovascular events, while early vascular aging was linked to a higher risk.
- - This research validates the supernormal vascular aging concept and suggests that understanding it could lead to new protective strategies for healthy vascular aging.
Article Synopsis
- The 2008 European Society of Cardiology and European Society of Hypertension guidelines recommend using single-pill combinations (SPCs) of two antihypertensive drugs as the first-line treatment for most patients with hypertension.
- The recommendation is supported by extensive data showing that SPCs help quickly achieve blood pressure targets, lower cardiovascular risks, and improve treatment adherence.
- Despite these advantages, some doctors are hesitant to adopt this new approach, and the review will explore these concerns and suggest ways to overcome them.
Article Synopsis
- The study investigates the connections between orthostatic hypotension, blood pressure (BP) variability, and arterial stiffness in elderly individuals, as these factors indicate cardiovascular risk.
- Researchers analyzed data from 1,151 participants, finding that those with orthostatic hypotension were more likely to have higher BP variability and increased arterial stiffness.
- The results suggest that orthostatic hypotension is linked to day-to-day BP variability and arterial stiffness, with BP variability possibly reflecting issues in baroreflex function, while arterial stiffness indicates vascular aging.
Article Synopsis
- Researchers derived an equation to estimate pulse wave velocity (ePWV) based on age and mean blood pressure, showing it can predict cardiovascular events independently of other common risk assessment tools like SCORE and Framingham Risk Score.
- The study analyzed data from over 107,000 healthy individuals aged 19 to 97 across multiple countries, examining how ePWV relates to various clinical outcomes and mortality through detailed statistical modeling.
- Results indicated that higher ePWV was linked to increased all-cause mortality and cardiovascular issues, but when adjusted for traditional risk factors, its association with cardiovascular mortality and composite end points was not significant.