Detection Dog Survey Detects African Wild Dog Presence and a Shared Marking Site.

African wild dog () populations are difficult to assess effectively and scalable strategies for population monitoring are lacking, often because of low detection rates. Scat detection dogs () have emerged as a suitable tool to detect the presence of wide-ranging carnivores. In this study, we employed a detection dog to locate African wild dog scat in an unfenced, understudied region of the Kavango-Zambezi Transfrontier Conservation Area.

Long QT syndrome in children and adolescents: risk factors and outcomes in a large German cohort.

Background And Aims: This study describes outcomes in a large contemporary national cohort of children and adolescents with long QT syndrome (LQTS).

Methods: Data analysis of 548 paediatric LQTS patients at 12 German tertiary care centres. Primary outcome was the occurrence of a major arrhythmic event (MAE) defined as sudden cardiac death (SCD), aborted cardiac arrest (ACA) and appropriate implantable cardioverter-defibrillator (ICD) therapy before age 18 years.

Serum Concentrations of Insulin-like Growth Factor-1 (IGF-1), 26S Proteasome (26S PSM), and 3-Methylhistidine (3-MH) in Cats with Hypertrophic Cardiomyopathy.

Background: Cardiomyopathies not only affect the cardiovascular system but can also have systemic implications. Despite their significance, only a few laboratory parameters are currently used to describe the metabolic effects of cardiomyopathies. This study aimed to explore a potential link between hypertrophic cardiomyopathy (HCM) and serum IGF-1, 26S PSM, and 3-MH concentrations in cats.

Diagnostic value of serum survivin, Ki-67 and thymidine kinase in dogs with nasal cavity disease.

Background: The most common nasal cavity disease (ND) in dogs is the malignant nasal cavity tumor. Prognosis and survival after radiation therapy are reported to correlate with tumor size, and therefore indirectly with the time to diagnosis. Diagnosis of a nasal tumor requires imaging procedures under anesthesia.

Magnetisation transfer, T1 and T2* relaxation in canine menisci of elderly dogs-an study in stifle joints.

Magnetic resonance imaging (MRI) is widely used in human medicine, offering multiple contrast mechanisms to visualise different tissue types. It is also gaining importance in veterinary medicine, including diagnosing joint disorders. The menisci of the stifle joint play a crucial role in the development of osteoarthritis (OA), and multi-parameter MRI of the menisci may aid in early OA diagnosis, potentially improving therapeutic outcomes.

Nematophagous fungi as biological control agents of parasitic nematodes in soils of wildlife parks.

Infections with soil-transmitted helminths pose a significant threat to wildlife in enclosures, where transmission of these parasitic larvae is easier due to the limited space. Nematophagous fungi offer a promising solution as they can naturally control these nematodes. In this study, three nematophagous fungi (, , ) purchased from the non-profit global biological resource center ATCC were tested for their suitability as biological control agents.

Exploring animal enclosures and parasite interactions in Germany.

In order to gain an initial impression of the current parasite situation in wildlife enclosures across Germany, 17 enclosures of six animal species were examined for parasites in soil and fecal samples in seven facilities. Of particular interest in this context are helminths and protists. Despite the potential risks, however, there are only a few studies on parasites in animal enclosures due to the taboo subject.

Low-Field Magnetic Resonance Imaging for the Detection of Medial Meniscal Lesions in Cranial Cruciate-Deficient Stifle Joints in Dogs.

Background: The aim of this study was to substantiate the ability of noninvasive low-field magnetic resonance imaging (lfMRI) to accurately depict meniscal lesions, thereby establishing lfMRI as a viable option for the diagnosis of meniscal pathology.

Study Design: This was a prospective, controlled study.

Materials And Methods: In each of 57 stifle joints, 5 predefined lfMRI sequences using a 0.

Investigation of α-Klotho Concentrations in Serum of Cats Affected by Hypertrophic Cardiomyopathy.

Being involved in various physiological and pathophysiological mechanisms (ageing, kidney damage, cardiovascular diseases, etc.), Klotho is a parameter of increasing interest. Studies in veterinary medicine are still rare, but it is exciting to find out whether the findings obtained can be transferred to animals.

Diagnostic benefits of platelet-to-lymphocyte, neutrophil-to-lymphocyte, and albumin-to-globulin ratios in dogs with nasal cavity diseases.

Background: A multimodal approach for diagnostic tests under anesthesia is required to diagnose nasal cavity pathology (NP) reliably in dogs. Blood test results may provide clues to the suspected NP.

Methods: This prospective blinded study assessed 72 dogs with chronic nasal discharge due to NPs, and 10 healthy dogs as the control group (CG).

Procalcitonin as an Endogenous Biomarker for Mastitis in Cows.

Mastitis is one of the most common diseases of dairy cows. Procalcitonin (PCT) has been described as an endogenous inflammatory biomarker for bacterial infections. The aim of this study was to find possible correlations between PCT concentrations in the serum and milk of cows with mastitis and their clinical signs and disease progression.

β-defensin-4 as an endogenous biomarker in cows with mastitis.

Introduction: Defensins are peptides with antimicrobial and immunomodulatory effects. Their concentration could be altered during infections and thus provide information on the prognosis and course of the disease. The aim of the present study was to investigate the defensin concentration in cows with mastitis in order to find correlations between clinical expression and course of the disease and the defensin concentration in milk and blood.

Histological Findings and T2 Relaxation Time in Canine Menisci of Elderly Dogs-An Ex Vivo Study in Stifle Joints.

Osteoarthritis is a chronic disease that often affects the canine stifle joint. Due to their biomechanical function, the menisci in the canine stifle play an important role in osteoarthritis. They compensate for the incongruence in the joint and distribute and minimize compressive loads, protecting the hyaline articular cartilage from damage.

Utility of Serum Ki-67 as a Marker for Malignancy in Dogs.

Tumour markers are scarcely used in veterinary medicine, although they are non-invasive, contribute to a faster diagnosis and new therapeutic options. The nuclear protein Ki-67 is absent in G-phase but is detectable throughout all active phases of the cell cycle. Consequently, it is used as a marker for the proliferating cell fraction of a cell population and thus could indicate neoplastic tissue present.

Narrative review of Ebstein's anomaly beyond childhood: Imaging, surgery, and future perspectives.

Ebstein's anomaly is a rare congenital heart disease with malformation of the tricuspid valve and myopathy of the right ventricle. The septal and inferior leaflets adhere to the endocardium due to failure of delamination. This leads to apical displacement of their hinge points with a shift of the functional tricuspid valve annulus towards the right ventricular outflow tract with a possibly restrictive orifice.

Investigation of procalcitonin and beta-defensin2 in the serum and feces of dogs with acute diarrhea.

Background: Acute diarrhea is a common clinical condition where clinical parameters are used to assess disease severity, course, and prognosis.

Objectives: The aim of this study was to investigate procalcitonin (PCT) and beta-defensin2 (Bdef2) as biomarkers for disease severity, course, and prognosis of dogs with acute diarrhea.

Methods: Dogs with acute diarrhea (enteritis group [EG], n = 35) were compared with 30 healthy controls.

Investigation of serum survivin in dogs suffering from cancer: a multicenter study.

Background: In contrast to human medicine, only a small number of serum tumor markers are established in veterinary medicine even though they are a non-invasive diagnostic tool.

Objectives: This study examined whether survivin could be suitable as a potential canine serum tumor marker.

Methods: This study measured the serum survivin concentrations of dogs with mammary tumors (n = 33), squamous cell carcinoma (n = 9), soft-tissue sarcoma (n = 18) and multicentric lymphoma (n = 22), using a commercially available, competitive immunoassay kit (BlueGene).

Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in dogs and cats with acute pancreatitis.

Background: Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been described as prognostic markers in cancer and inflammatory diseases. The use of these measurements in dogs and cats with acute pancreatitis has not yet been investigated.

Objective: The objective was to evaluate NLR and PLR for usefulness as biomarkers for severity and clinical course of acute pancreatitis in dogs and cats.

Reference Interval of Hemoglobin A1c and Influence of Hematological Parameters on Its Serum Concentration in Dogs.

HbA1c could be an alternative to fructosamine as a marker for glucose levels over a longer period. In this study, we calculated a reference interval for HbA1c in dogs and investigated the correlation of HbA1c with hemoglobin and different hematological parameters. In total, 110 blood samples from dogs were investigated.

Stability of canine urine samples under different storage conditions.

The stability of canine urine samples is essential when the samples cannot be analyzed immediately. The objective of this study was to investigate the stability of canine urine samples at room temperature and under refrigerated conditions. Samples from 20 dogs were collected, divided, and stored at 4°C and 20°C.

Evaluation of transforming growth factor beta 1 in dogs with osteoarthritis.

Osteoarthritis is a common problem in daily veterinary practice with insufficient knowledge about disease mechanism. Because fibrosis is a part of the alteration in the effected joints, we investigated the transforming growth factor beta 1 (TGF-β1) as an important regulation molecule of tissue fibrosis. We chose Osteoarthritis following a cruciate ligament rupture (CLR) because it is a common model of osteoarthritis.

26S proteasome and insulin-like growth factor-1 in serum of dogs suffering from malignant tumors.

Studies in humans have shown that the ubiquitin-proteasome pathway and the insulin-like growth factor axis are involved in carcinogenesis, thus, components of these systems might be useful as prognostic markers and constitute potential therapeutic targets. In veterinary medicine, only a few studies exist on this topic. Here, serum concentrations of 26S proteasome (26SP) and insulin-like growth factor-1 (IGF-1) were measured by canine enzyme-linked immunosorbent assay (ELISA) in 43 dogs suffering from malignant tumors and 21 clinically normal dogs (control group).

Evaluation of serum insulin-like growth factor-1 and 26S proteasome concentrations in healthy dogs and dogs with chronic diseases depending on body condition score.

In patients suffering from chronic diseases, the objective assessment of metabolic states could be of interest for disease prognosis and therapeutic options. Therefore, the aim of this study was to assess insulin-like growth factor-1 (IGF-1) and 26S proteasome (26SP) in healthy dogs and dogs suffering from chronic diseases depending on their body condition score (BCS) and to examine their potential for objective assessment of anabolic and catabolic states. Serum concentrations of IGF-1, an anabolic hormone, and 26SP, a multiprotein complex which is part of the ubiquitin-proteasome pathway, by which the majority of endogenous proteins including the muscle proteins are degraded, were measured in 21 healthy dogs and 20 dogs with chronic diseases by canine ELISA.

TGF-β1 serum concentrations and receptor expressions in the lens capsular of dogs with diabetes mellitus.

Tissue fibrosis as complication of diabetes mellitus is known in humans. Because TGF-β1induces fibrosis and is elevated in humans suffering from diabetes mellitus we measured this growth factor in serum of dogs with diabetes mellitus and compared it with healthy dogs and those with fibrotic diseases. Further we measured the expression of TGF-β1receptor on lens capsule to investigate possible association between diabetes mellitus and cataract associated alterations.