Publications by authors named "Sophia Cosmich"
Background: Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) modulators are available to the majority of people with CF in the United States; little is known about pregnancy outcomes with modulator use. The aim of this retrospective study was to determine the impact of CFTR modulators on maternal outcomes.
Research Question: Does pregnancy differentially affect outcomes in female individuals with CF with and without CFTR modulator exposure?
Study Design And Methods: Data on pregnancies from 2010 to 2021 were collected from 11 US adult CF centers.
Article Synopsis
- Historically, female patients with cystic fibrosis (CF) have worse pulmonary outcomes and life expectancy than males, but it's unclear if this gap remains with modern treatments like ivacaftor.
- A study compared the effects of ivacaftor on male and female patients in terms of pulmonary exacerbation rates, lung function, and Pseudomonas aeruginosa presence, including data from 1,900 patients treated between 2010 and 2017.
- Results indicated that while male patients experienced a significant decrease in exacerbations after treatment, female patients did not show the same improvement, suggesting that sex disparities in CF outcomes continue even with effective therapies.