Publications by authors named "Soham Tarafdar"
Article Synopsis
- - This study demonstrated that up to 80% of malignant thyroid nodules showed detectable driver mutations in plasma samples, indicating a potential noninvasive diagnostic approach for identifying cancer before surgery.
- - The researchers found a strong correlation between mutations identified in plasma and those found in fine-needle aspiration (FNA) and histopathology samples, with RAS mutations detected in nearly 90% of follicular adenomas.
- - The findings suggest that using cell-free nucleic acids from plasma could improve preoperative assessments of thyroid tumors and aid in monitoring tumor recurrence after surgery, warranting further research in this area.
Plasma Cell-Free DNA to Differentiate Malignant from Benign Thyroid Nodules.
J Clin Endocrinol Metab
April 2021
Background: Molecular testing is increasingly used to identify malignancy in thyroid nodules (especially indeterminate category). Measurement of cell-free DNA (cfDNA) levels from plasma has been useful in diagnosis of cancers of other organs/tissues; herein we analyze cfDNA levels in patients with thyroid nodules to explore the possibility of establishing a cutoff for identification of malignancy.
Methods: Patients underwent ultrasonography (USG) and USG-guided fine needle aspiration as well as surgery, where indicated.
Comparison between Sonographic Features and Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule.
Indian J Endocrinol Metab
August 2020
Article Synopsis
- High resolution ultrasonography (USG) is used to evaluate thyroid nodules, with the Thyroid Imaging Reporting and Data System (TIRADS) providing risk classification that guides further testing like fine needle aspiration cytology (FNAC).
- The study observed 137 euthyroid nodules, comparing USG findings and FNAC results to surgical biopsy outcomes, revealing that FNAC is more specific for diagnosing malignancy (90% specificity) compared to TIRADS.
- Key features from USG, such as micro-calcifications, irregular margins, and shape, were identified as highly sensitive and specific indicators of malignancy, although some benign cases could still show suspicious USG features.