Human Placenta Hydrolysate Protects Against Acetaminophen-Induced Liver Injury in Mice.

: Acetaminophen (APAP) is a widely used analgesic and antipyretic, but overdose can lead to APAP-induced liver injury (AILI), a major cause of acute liver failure. While N-acetylcysteine (NAC) is the current standard of care, its efficacy is significantly reduced when administered after the peak time of liver injury, highlighting the need for alternative therapeutic strategies. Human placenta hydrolysate (HPH) has shown potential as a therapeutic agent for various liver diseases due to its rich content of bioactive compounds.

Skeletal Muscle Atrophy Induced by Dexamethasone Is Attenuated by Amino Acid Complex Supplementation in Rats.

Muscle atrophy, a physiological decline in muscle mass and strength due in ageing, occurs through an imbalance between protein breakdown and synthesis. The purpose of this study was to verify whether amino acid complex supplementation (ACS) can prevent and treat muscle loss in a dexamethasone (Dexa, 800 μg/kg)-induced rat model of sarcopenia. Sprague Dawley rats (6 weeks old) were assigned to seven groups: (i) normal control, (ii) positive control (high-dose ACS, 500 mg), (iii) Dexa only, (iv) Dexa + high-dose ACS (500 mg), (v) Dexa + medium-dose ACS (300 mg), (vi) Dexa + low-dose ACS (100 mg), or (vii) Dexa + liquid amino acid complex formulation (LF, 2 mL), administered orally for 4 weeks.

Development of a Short-Term Embolic Agent Based on Cilastatin for Articular Microvessels.

: This study aimed to develop an embolic agent with short-term embolic effects using cilastatin as the basic material. : The particle size distribution of 25 mg cilastatin-based short-term embolic agents was evaluated microscopically under three different mixing conditions. A total of thirty-six healthy male Sprague Dawley rats were divided into four groups.

Comparison of the Effects of Pilates and Yoga Exercise on the Dynamic Balancing Ability and Functional Movement of Fencers.

This study was conducted to compare and analyze whether Pilates exercise and yoga exercise help improve the performance of female fencers and prevent injury, and the dynamic balance test (LQ-YBT) and functional movement screening (FMS) test score of the elite adult female fencers were compared and analyzed as evaluation indicators. Participants were randomly classified into Pilates ( = 10) and yoga groups ( = 10), members of which took part in 50 min of exercise (5 min of warm-up, 40 min of main exercise, and 5 min of cool-down) twice weekly for eight weeks. The results obtained from this study were analyzed via independent -test and 2-way ANOVA.

Comprehensive immune profiling and immune-monitoring using body fluid of patients with metastatic gastric cancer.

Background: The aim of this study is to profile the cytokines and immune cells of body fluid from metastatic gastric cancer (mGC), and evaluate the potential role as a prognostic factor and the feasibility as a predictive biomarker or monitoring source for immune checkpoint inhibitor.

Methods: Body fluid including ascites and pleural fluid were obtained from 55 mGC patients and 24 matched blood. VEGF-A, IL-10, and TGF-β1 were measured and immune cells were profiled by fluorescence assisted cell sorting (FACS).

Educational differences in early childbearing: A cross-national comparative study.

Background: Recent research on fertility in industrialized countries focuses primarily on delayed childbearing, despite the facts that large numbers of women continue to enter parenthood at relatively young ages and that early childbearing has been linked to economic disadvantage.

Objective: This cross-national comparative study describes relationships between women's educational attainment and young age at first birth and evaluates the extent to which these differences have changed over time for women born 1955-1981.

Methods: Defining 'early' childbearing as the age by which 20% of first births have occurred to women in a given birth cohort and country, we describe differences in early childbearing by educational attainment across three cohorts of women in 20 countries.

Nonstandard Work and Educational Differentials in Married Women's Employment in Japan: Patterns of Continuity and Change.

The rapid expansion of nonstandard work has altered the nature of women's employment, but previous research on married women's employment trajectories in japan has paid little attention to the role of nonstandard work. to fill this gap, we examine how patterns of employment in regular and nonstandard positions vary by married women's socioeconomic status using nationally representative longitudinal data. results from discrete-time competing risks models of labor force transitions indicate that university graduates have the most stable labor force attachment in that they are the least likely to move from standard to nonstandard employment and to exit nonstandard jobs.

Infant mortality in Kyrgyzstan before and after the break-up of the Soviet Union.

There is a great deal of uncertainty over the levels of, and trends in, infant mortality in the former Soviet republics of Central Asia. As a result, the impact of the break-up of the Soviet Union on infant mortality in the region is not known, and proper monitoring of mortality levels is impaired. In this paper, a variety of data sources and methods are used to assess levels of infant mortality and their trend over time in one Central Asian republic, Kyrgyzstan, between 1980 and 2010.