Targeting Global Coverage: Comparison of In-Hospital OGTT at 2-3 Days Postpartum with OGTT at 6-12 Weeks Postpartum for Predicting Glucose Intolerance in Postpartum Women with Gestational Diabetes Mellitus.

Background: Recognizing the importance of postpartum testing for dysglycaemia after gestational diabetes mellitus (GDM), follow-up visit is recommended by all guidelines; unfortunately, dropout rate for follow-up is very high.

Objective: Comparison of diagnostic accuracy of early OGTT on day 2 or 3 postpartum with late OGTT at 6-12 weeks for predicting dysglycaemia in women with GDM in index pregnancy.

Methods: A total of 250 women with GDM underwent early WHO OGTT testing at 2-3 days postpartum, repeated at 6-12 weeks postpartum.

Targeted NGS-Based Analysis of Reveals Novel Genotypes.

is an important etiological agent of pneumonia that is underdiagnosed due to the inability to culture the organism. The 2019 PERCH study identified as the top fungal cause of pneumonia in HIV-negative children using a PCR cutoff of 10 copies of per mL of sample in nasopharyngeal/oropharyngeal (NP/OP) specimens. Given that consists of an environmental ascus form and a trophic from (the latter is the form that attaches to the lung epithelium), it is possible that life-form-specific molecular assays may be useful for diagnosis.

Specific Protein Rv1509 Evokes Efficient Innate and Adaptive Immune Response Indicative of Protective Th1 Immune Signature.

Dissecting the function(s) of proteins present exclusively in () will provide important clues regarding the role of these proteins in mycobacterial pathogenesis. Using extensive computational approaches, we shortlisted ORFs/proteins unique to among 13 different species of mycobacteria and identified a hypothetical protein Rv1509 as a 'signature protein' of . This unique protein was found to be present only in and absent in all other mycobacterial species, including BCG.

Bacteria Expressing -Specific Rv1954A Induce Macrophage Activation and Modulate the Immune Response.

(), the intracellular pathogen causing tuberculosis, has developed mechanisms that endow infectivity and allow it to modulate host immune response for its survival. Genomic and proteomic analyses of non-pathogenic and pathogenic mycobacteria showed presence of genes and proteins that are specific to . studies predicted that Rv1954A is a hypothetical secretory protein that exhibits intrinsically disordered regions and possess B cell/T cell epitopes.

Immunodominant Protein Rv1507A Elicits Th1 Response and Modulates Host Macrophage Effector Functions.

() persists as latent infection in nearly a quarter of the global population and remains the leading cause of death among infectious diseases. While BCG is the only vaccine for TB, its inability to provide complete protection makes it imperative to engineer BCG such that it expresses immunodominant antigens that can enhance its protective potential. comparative genomic analysis of Mycobacterium species identified Rv1507A as a "signature protein" found exclusively in .

In vivo effect of two different dietary fiber blends on the milk calcium bioavailability.

Milk is a valuable source of dietary calcium and it becomes important to establish whether incorporation of dietary fiber (DF), a health promoting food constituent, would lead to any undesirable impact on the bioavailability of milk calcium or not. The DF fortified spray dried partly skimmed milk powder with prestandardized fiber Blend-I (psyllium husk, oat fiber, MCC, inulin) and fiber Blend-II (psyllium husk, oat bran, wheat fiber and inulin) was subjected to rat-feeding studies to examine the possible effects on the bioavailability of milk calcium. The differences for calcium absorption and retention among diets containing DF Blend-I, DF Blend-II and cellulose (control) were found to be non-significant.

Process optimization and characterization of 'sev' (traditional Indian extruded snack) with the incorporation of mushroom powder.

Mushroom is a nutritious and palatable food with various health attributes. The mushroom powder is a rich source of vegetable protein. In the present study, efforts were made to optimize the process for making , a traditional Indian extruded snack, with the incorporation of mushroom powder () to the Bengal gram ( L.

Contrasting Function of Structured N-Terminal and Unstructured C-Terminal Segments of PPE37 Protein.

Pathogens frequently employ eukaryotic linear motif (ELM)-rich intrinsically disordered proteins (IDPs) to perturb and hijack host cell networks for a productive infection. has a relatively high percentage of IDPs in its proteome, the significance of which is not known. The -specific PE-PPE protein family has several members with unusually high levels of structural disorder and disorder-promoting Ala/Gly residues.

Effect of fiber blends, total solids, heat treatment, whey protein concentrate and stage of sugar incorporation on dietary fiber-fortified .

Owing to the proven beneficial role of dietary fiber (DF) on human health, feasibility of incorporating commercially available soluble and insoluble DF preparations into rice-milk-pudding ( a popular Indian delicacy) was studied through process modification. The novel approach of preparing reduced fat DF-fortified- (DFFK) by developing liquid/cream phase and particulate/rice phase separately, and subsequently blending the two was developed. The major processing variables studied were total solids (TS) in the liquid phase, type of fiber blend, flavor-simulation through heat treatment or added whey protein, and the presence of sugar in water for pre-cooking of rice.

Determination of relationship between sensory viscosity rating and instrumental flow behaviour of soluble dietary fibers.

The shear-thinning low, medium and high-viscosity fiber preparations (0.15-1.05 % psyllium husk, 0.

miRNet - dissecting miRNA-target interactions and functional associations through network-based visual analysis.

MicroRNAs (miRNAs) can regulate nearly all biological processes and their dysregulation is implicated in various complex diseases and pathological conditions. Recent years have seen a growing number of functional studies of miRNAs using high-throughput experimental technologies, which have produced a large amount of high-quality data regarding miRNA target genes and their interactions with small molecules, long non-coding RNAs, epigenetic modifiers, disease associations, etc These rich sets of information have enabled the creation of comprehensive networks linking miRNAs with various biologically important entities to shed light on their collective functions and regulatory mechanisms. Here, we introduce miRNet, an easy-to-use web-based tool that offers statistical, visual and network-based approaches to help researchers understand miRNAs functions and regulatory mechanisms.