Targeting Global Coverage: Comparison of In-Hospital OGTT at 2-3 Days Postpartum with OGTT at 6-12 Weeks Postpartum for Predicting Glucose Intolerance in Postpartum Women with Gestational Diabetes Mellitus.

Background: Recognizing the importance of postpartum testing for dysglycaemia after gestational diabetes mellitus (GDM), follow-up visit is recommended by all guidelines; unfortunately, dropout rate for follow-up is very high.

Objective: Comparison of diagnostic accuracy of early OGTT on day 2 or 3 postpartum with late OGTT at 6-12 weeks for predicting dysglycaemia in women with GDM in index pregnancy.

Methods: A total of 250 women with GDM underwent early WHO OGTT testing at 2-3 days postpartum, repeated at 6-12 weeks postpartum.

Association of Traumatic Brain Injury with Subsequent Psychiatric and Neurological Conditions: A Meta-Analysis.

This research aims to evaluate the association between traumatic brain injury (TBI) and the development of subsequent neurological and psychiatric disorders. A comprehensive literature search was conducted using PubMed for studies published from 1995 to 2012. Fifty-seven studies were included based on predefined inclusion criteria.

Perceptions of healthcare workers and patients on the implementation of telemedicine in hard-to-reach areas: A qualitative study from rajasthan, India.

Objective: To explore the perceptions of healthcare providers and patients regarding the implementation of telemedicine in hard-to-reach areas of Rajasthan, India, and identify factors influencing its adoption and effectiveness.

Methods: A qualitative study was conducted using 24 in-depth interviews with healthcare providers from primary health centres and a district hospital, as well as patients from remote areas in Balotra district of Rajasthan. Thematic analysis was used to identify key themes related to the acceptance, benefits, challenges, and recommendations for telemedicine adoption.

Avertible filicide: a call to action for early intervention and mental health support in India.

Purpose: Maternal filicide is a deeply distressing and potentially preventable phenomenon that demands priority attention. This study aims toshed light on the psychological, social and systemic factors contributing to maternal filicide. It calls for robust early intervention strategies and the establishment of comprehensive mental health support systems to mitigate the risk and prevent the occurence of such tragedies.

A Rare Presentation of Disseminated Peritoneal Leiomyomatosis Following Laparoscopic Hysterectomy and Its Multidisciplinary Management.

Disseminated peritoneal leiomyomatosis (DPL) is a rare entity. It is a benign disease but can mimic disseminated malignancy with extensive disease at multiple sites within the abdominopelvic cavity. The primary contributing factor is postulated to be peritoneal spillage of benign leiomyoma, especially after laparoscopic intervention, although hormonal influences might also play a role.

Fusion transcripts in plants: hidden layer of transcriptome complexity.

In the realm of genetic information, fusion transcripts contribute to the intricate complexity of the transcriptome across various organisms. Recently, Cong et al. investigated these RNAs in rice, maize, soybean, and arabidopsis (Arabidopsis thaliana), revealing conserved characteristics.

Probing Aromatic Side Chains Reveals the Site-Specific Melting in the SUMO1 Molten Globule.

The conventional idea that a well-defined protein structure governs its functions is being challenged by the evolving significance of conformational flexibility and disorder in influencing protein activity. Here, we focus on the Small Ubiquitin-like MOdifier 1 (SUMO1) protein, a post-translational modifier, which binds various target proteins during the process of SUMOylation. We present evidence supporting the presence of both folded and "ordered" molten globule (MG) states in SUMO1 under physiological conditions.

PFusionDB: a comprehensive database of plant-specific fusion transcripts.

Unlabelled: Fusion transcripts (FTs) are well known cancer biomarkers, relatively understudied in plants. Here, we developed PFusionDB (www.nipgr.

Exhaled Breath Condensate Surveillance for in Acute Leukemia-a Pilot Trial.

Invasive fungal infections in patients with leukemia carry a high mortality rate, but early diagnosis has the potential to modify this natural history. A novel screening method using droplet-digital polymerase chain reaction in exhaled breath condensate may have a similar performance to serum galactomannan screening. Larger studies, including other molds, are necessary.

Challenges, Barriers, and Facilitators in Telemedicine Implementation in India: A Scoping Review.

Telemedicine has revolutionized healthcare access by breaking geographical barriers and facilitating remote consultations. The eSanjeevani platform has been pivotal in India, especially during the COVID-19 pandemic. Despite its benefits, implementing telemedicine faces various challenges and barriers.

In Silico Identification of tRNA Fragments, Novel Candidates for Cancer Biomarkers, and Therapeutic Targets.

The identification of a wide variety of RNA molecules using high-throughput sequencing techniques in the transcriptome pool of living organisms has revealed hidden regulatory insights in the cell. The class of non-coding RNA fragments produced from transfer RNA, or tRFs, is one such example. They are heterogeneously sized molecules with lengths ranging between 15 and 50 nt.

A Protocol for the Detection of Fusion Transcripts Using RNA-Sequencing Data.

Fusion transcripts are formed when two genes or their mRNAs fuse to produce a novel gene or chimeric transcript. Fusion genes are well-known cancer biomarkers used for cancer diagnosis and as therapeutic targets. Gene fusions are also found in normal physiology and lead to the evolution of novel genes that contribute to better survival and adaptation for an organism.

Effect of male parental gamma irradiation on host suitability of its F1 progeny of a lepidopteran tropical pest, Spodoptera litura (Fabr.) towards development and virulence of entomopathogenic nematodes, Steinernema thermophilum.

The suitability of F1 progeny insect larvae of the irradiated male parent, Spodoptera litura (Fabr.) for infective juveniles (IJs) of entomopathogenic nematodes (EPN), Steinernema thermophilum was assessed to comprehend the feasibility of combining EPNs with nuclear pest control tactic. As compared to the control, the IJs induced faster host mortality with reduced proliferation in F1 host larvae.

Phase Separation and Aggregation of a Globular Folded Protein Small Ubiquitin-like Modifier 1 (SUMO1).

Liquid-liquid phase separation (LLPS) plays a crucial role in cellular organization, primarily driven by intrinsically disordered proteins (IDPs) leading to the formation of biomolecular condensates. A folded protein SUMO that post-translationally modifies cellular proteins has recently emerged as a regulator of LLPS. Given its compact structure and limited flexibility, the precise role of SUMO in condensate formation remains to be investigated.

Activity Guided Azide-methyllysine Photo-trapping for Substrate Profiling of Lysine Demethylases.

Reversible post-translational modifications (PTMs) are key to establishing protein-protein and protein-nucleic acid interactions that govern a majority of the signaling pathways in cells. Sequence-specific PTMs are catalyzed by transferases, and their removal is carried out by a class of reverse-acting enzymes termed "detransferases". Currently available chemoproteomic approaches have been valuable in characterizing substrates of transferases.

Lymphoepithelial Carcinoma of the Breast.

Lymphoepithelial malignancy is an extremely rare carcinoma of the breast characterized by a confusing histopathological picture resembling medullary carcinomas, lymphoma, etc. It has also been reported in other regions of the body like salivary glands, nasopharyngeal area and sometimes the lung. Due to its rare presence and difficult diagnosis, the treatment is often prolonged and delayed.

Navigation for youth mental health and addictions: protocol for a realist review and synthesis of approaches and practices (The NavMAP standards project).

Introduction: Mental health and/or addiction (MHA) concerns affect approximately 1.2 million children and youth in Canada, yet less than 20% receive appropriate treatment for these concerns. Youth who do not receive appropriate support may disengage from care and may experience lasting MHA issues.

Targeted NGS-Based Analysis of Reveals Novel Genotypes.

is an important etiological agent of pneumonia that is underdiagnosed due to the inability to culture the organism. The 2019 PERCH study identified as the top fungal cause of pneumonia in HIV-negative children using a PCR cutoff of 10 copies of per mL of sample in nasopharyngeal/oropharyngeal (NP/OP) specimens. Given that consists of an environmental ascus form and a trophic from (the latter is the form that attaches to the lung epithelium), it is possible that life-form-specific molecular assays may be useful for diagnosis.