Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function.

KCNQ1 potassium channels are essential for physiological processes such as cardiac rhythm and intestinal chloride secretion. KCNE family subunits (KCNE1-5) associate with KCNQ1, conferring distinct properties across various tissues. KCNQ1 activation requires membrane depolarization and phosphatidylinositol 4,5-bisphosphate (PIP2) whose cellular levels are controlled by Gαq-coupled GPCR activation.

Mechanisms of KCNQ1 gating modulation by KCNE1/3 for cell-specific function.

KCNQ1 potassium channels are essential for physiological processes such as cardiac rhythm and intestinal chloride secretion. KCNE-family subunits (KCNE1-5) associate with KCNQ1, conferring distinct properties across various tissues. KCNQ1 activation requires membrane depolarization and phosphatidylinositol 4,5-bisphosphate (PIP2) whose cellular levels are controlled by Gαq-coupled GPCR activation.

Ganomycin C, a Ganoderma Meroterpenoid, Alleviates Pain and Absence Seizures in Mice by Targeting Ca3.1 and Ca3.2 Low-Voltage-Gated Calcium Channels.

Low-voltage-gated calcium channels (LVGCCs; Ca3.1-3.3) are promising targets for treating pain and absence seizures (ASs).

Icetexane diterpenoids as Ca3.2 T-type calcium channel inhibitors from Salvia prattii and analgesic effect of their Semi-synthesized derivatives.

Ten new icetexane diterpenoids, salpratins E-N (1-10) and a known analogue (11) were characterized from Salvia prattii Hemsl. Structurally, 1 is the first 19(4 → 3)-abeo-icetexane diterpenoid featuring with a 6/7/6 ring system. The structures of isolated compounds were determined by comprehensive analyses of spectroscopic data, ECD calculation, and single-crystal X-ray diffraction.

Discovery of novel coffee diterpenoids with inhibitions on Ca3.1 low voltage-gated Ca channel.

Seven new (1-4, 6-8) diterpenoids with rare skeletons and seven known ones (9, 12, 17, 18 and 23-25) were isolated from roasted beans of Coffea arabica L. Together with previously obtained diterpenoids, a total of 26 molecules (1-25, 4a) were evaluated their activities on Ca3.1 low voltage-gated Ca channel.

Novel Meroterpenoids from : Highly Potent Late Na1.5 Sodium Current Inhibitors.

Hypulatones A and B ( and ), two racemic meroterpenoids possessing an unprecedented spiro[benzofuran-2,1'-cycloundecan]-4'-ene-4,6(5)-dione core, were characterized from . Compound was found to significantly inhibit the late current of Na1.5 (late , IC = 0.

Congenetic Hybrids Derived from Dearomatized Isoprenylated Acylphloroglucinol with Opposite Effects on Ca3.1 Low Voltage-Gated Ca Channel.

A hybrid of dearomatized isoprenylated acylphloroglucinol (DIAP) and monoterpenoid, hypatone A (), together with its biosynthetic analogues - is characterized from . Structurally, possesses an unprecedented spiro[bicyclo[3.2.