Supramolecular Detoxification Approach of Endotoxin Through Host-Guest Complexation by a Giant Macrocycle.

In Gram-negative bacteria, lipopolysaccharides (LPSs, also known as endotoxin) can induce extensive immune responses that will enable victims to produce severe septic shock syndrome. Because of the high mortality of sepsis in the face of standard treatment, advance detoxification schemes are urgently needed in clinics. Herein, we described a supramolecular detoxification approach via direct host-guest complexation by a giant macrocycle.

Porous pillar[6]arene-based polymers for reversible iodine capture.

Iodine in nuclear waste can cause serious environment pollution and health risks, and has thus driven more development of materials for iodine capture. Herein, a novel porous pillar[6]arene-based polymer (P-P6APs) was easily prepared as a supramolecular adsorbent for iodine a one-step crosslinking reaction between per-hydroxylated pillar[6]arene and decafluorobiphenyl. Nitrogen adsorption tests demonstrated that this material possessed a satisfactory surface area ( = 366 m g) and pore diameter (3.

Macrocycle-based self-assembled amphiphiles for co-delivery of therapeutic combinations to tumor.

For tumor treatment, the efficiency of single chemotherapeutic agent is generally limited and the traditional combination chemotherapies frequently result in the aggravation of side effects. Herein, an amphiphilic pillararene-based self-assembled nanoparticle (APSN) composed of hydrazide-pillar[5]arene (HP5A-6C) that achieve effective co-delivery of therapeutic combinations was reported. Through integrating multitudinous macrocyclic cavities into a single nanoparticle, the APSN could co-load two antitumor drugs, cisplatin (CP) and nitrogen mustard (NM) via host-guest interactions.

A giant macrocycle overcomes the post-treatment phototoxicity of photofrin through host-guest complexation.

Here we reported a supramolecular sequestration strategy to overcome the post-treatment phototoxicity of photofrin direct host-guest complexation. Efficient recognition potency of a giant pentaphen[3]arene derivative could favor suppressing sunlight-induced skin damage through weakening the ability of complexed photofrin to generate singlet oxygen.

Removal of formaldehyde from indoor air by potted Sansevieria trifasciata plants: dynamic influence of physiological traits on the process.

Plant-based removal of indoor formaldehyde is a widely studied method, yet little is known about the dynamic changes in this process. In this study, potted Sansevieria trifasciata Prain plants were exposed to 5-ppm formaldehyde gas concentration for 7 days. The results showed that formaldehyde exposure led to plant stress, affected photosynthesis, and damaged membrane lipids, as evidenced by a decrease in chlorophyll content, an increase in Chl a/b ratio and malondialdehyde content.

Sulfonated Azocalix[4]arene: A Universal and Effective Taste-Masking Agent.

Many active pharmaceutical ingredients have a specific bitter taste. To enhance patient compliance and treatment efficacy, taste-masking agents are crucial in oral drug formulations. Confronting numerous bitter drug molecules with varied structures, the pharmaceutical field strives to explore and develop universal and effective masking approaches.

Endophyte-assisted non-host plant Tillandsia brachycaulos enhance indoor formaldehyde removal.

This study investigated the use of endophyte-assisted Tillandsia brachycaulos to enhance formaldehyde removal in indoor environments. A formaldehyde-degrading endophyte from the root of Epipremnum aureum, Pseudomonas plecoglossicida, was identified and used for inoculation. Among the inoculation methods, spraying proved to be the most effective, resulting in a significant 35 % increase in formaldehyde removal after 36 hours.

Obtainment and Inoculation of Acinetobacter pittii Strain JJ-2, and Combined Action with Plants for Formaldehyde and CO Removal: A Research Study.

A formaldehyde-degrading bacterium JJ-2 was isolated from the rhizosphere of Chlorophytum and identified as Acinetobacter pittii by colony morphology and 16S rDNA sequence analysis. Further studies showed that under optimal conditions, JJ-2 could maintain activity for six cycles at an initial formaldehyde concentration of 450 mg L. At the same time, the complete degradation time was shortened from 12 to 6 h.

Comprehensive understanding the transition behaviors and mechanisms of chlorine and metal ions in municipal solid waste incineration fly ash during thermal treatment.

Municipal solid waste incineration fly ash is classified as the hazardous waste because of its high levels of heavy metals alkali chlorides, and polychlorinated dibenzo-p-dioxins. Thermal treatment is widely used for fly ash treatment because of its advantages of reduction and harmless. The transformation behaviors of chlorine and metal ions during the thermal treatment of fly ash has a significant impact on the harmless and resource of fly ash.

Cyclization of N-Terminal Glutamic Acid to pyro-Glutamic Acid Impacts Monoclonal Antibody Charge Heterogeneity Despite Its Appearance as a Neutral Transformation.

Pyroglutamic acid (pyroGlu) is commonly observed at the N-terminus of therapeutic monoclonal antibodies. Notably, the term "pyroGlu" refers to a single product that could originate from the cyclization of either an N-terminal glutamine or an N-terminal glutamic acid. This is an important and easily overlooked distinction that has major implications on the charge variant nature of a pyroGlu relative to its uncyclized form.

Enablement of the direct analysis of excipients in monoclonal antibody formulations through the incorporation of a wide pore C18 protein trap with hydrophilic interaction liquid chromatography.

Establishing and maintaining the correct formulation composition is essential for ensuring the stability of biopharmaceutical drug products. A barrier to the routine assessment of excipient concentration is the lack of convenient and robust methods for the direct analysis of solutions containing high protein concentrations. To address this need an HPLC method was developed utilizing a wide-pore C18 guard column to trap proteins in-line with a hydrophilic interaction liquid chromatographic column to separate excipients.

Controlled in situ reaction for the assembly of Cu(II) mixed-ligand coordination polymers: synthesis, structure, mechanistic insights, magnetism and catalysis.

It has been a challenge to decipher the in situ ligand reaction mechanism in assembly processes, involving metals and ligands. The present study shows two crystalline mixed-ligand Cu(II) coordination polymers isolated by controlled in situ ligand reactions under the same hydrothermal conditions. Two closely related examples provide a precious chance to access the in-depth mechanistic issues surrounding in situ reactions.

Dental calculus composition following use of essential-oil/ZnCl2 mouthrinse.

Purpose: To test the hypothesis that anticalculus agents cannot completely inhibit calculus formation but can influence the types of calcium phosphate which form, i.e., they can influence the composition of the inorganic component of human dental calculus (HDC).

Adherent octacalciumphosphate coating on titanium alloy using modulated electrochemical deposition method.

Our aims in this study were (1) to develop an electrochemical method of depositing adherent octacalciumphosphate (OCP) and other calcium phosphate coatings on titanium alloy (Ti6Al4V) substrates of different shapes and surface preparations, (2) to determine the properties of the coating (composition, morphology, thickness, dissolution), and (3) to observe transformation of OCP to carbonatehydroxyapatite (CHA) in simulated body fluid (SBF). Titanium (Ti)-alloy plates, tensile bars with four types of surfaces (grit-blasted with apatitic abrasive, chemically textured, arc-deposited, and Co-Cr-beaded) and dissolution cylinders were electrochemically coated with the use of modulated pulse time electric fields programmed with a custom-made dual microprocessor. Modulated electrochemical deposition (MECD) was carried out with pH and temperature conditions favorable for OCP formation.