NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming.

Purpose: Cancer cells rely on serine biosynthesis for growth, but its regulation in colorectal cancer (CRC) remains not well understood. This study identifies the mC methyltransferase NSUN2 (NOP2/Sun domain family, member 2) as a key regulator of serine biosynthesis, revealing a novel mechanism driving CRC progression.

Methods: The expression and prognostic value of NSUN2 were evaluated using bioinformatics analyses and immunohistochemistry (IHC) assays.

Silk Fibroin Nanoparticles for Enhanced Cuproptosis and Immunotherapy in Pancreatic Cancer Treatment.

Cuproptosis is a newly discovered copper ion-dependent programmed cell death. Elesclomol (ES) is a Cu transporter that delivers Cu into tumor cells, causing cell death at toxic doses. However, ES has a short blood half-life, limiting its accumulation in tumors.

IGF2BP3 promotes progression of gallbladder carcinoma by stabilizing KLK5 mRNA in N-methyladenosine-dependent binding.

Background: Recent studies have reported that IGF2BP3 is linked to the pathogenesis of various malignancies. Since IGF2BP3 is associated with poor outcomes of gallbladder carcinoma (GBC), we aimed to explore the association between its N-methyladenosine (m6A) RNA methylation and GBC progression.

Methods: Bioinformatic analysis of GSE136982, GSE104165, and RNA-seq was performed.