Development and Immunogenic Evaluation of a Recombinant Vesicular Stomatitis Virus Expressing Nipah Virus F and G Glycoproteins.

Nipah virus (NiV) is a highly pathogenic bat-borne zoonotic pathogen that poses a significant threat to human and animal health, with fatality rates exceeding 70% in some outbreaks. Despite its significant public health impact, there are currently no licensed vaccines or specific therapeutics available. Various virological tools-such as reverse genetics systems, replicon particles, VSV-based pseudoviruses, and recombinant Cedar virus chimeras-have been widely used to study the molecular mechanisms of NiV and to support vaccine development.

Susceptibility of Ferret and Cat to Porcine Deltacoronavirus: Evidence of Infection in Ferrets But Not Cats.

Coronaviruses (CoVs) cause gastrointestinal and respiratory disorders and have a wide host range. Porcine deltacoronavirus (PDCoV) is an enteropathogenic CoV and a member of the (δ-CoV) genus and was discovered in 2012. With a high fatality rate, PDCoV is primarily responsible for severe diarrhea in pigs, especially in newborn piglets, and has been reported worldwide since the first outbreak in 2014.

Differential Susceptibility to Porcine Deltacoronavirus: Ducks Show Greater Vulnerability Than Geese.

Porcine deltacoronavirus (PDCoV), an enteropathogenic coronavirus belonging to the genus, is globally distributed and represents a significant viral enteric disease in pigs. It primarily causes severe diarrhea in pigs, especially in newborn piglets, with high fatality rates, resulting in substantial losses to the pig farming industry. Notably, PDCoV is also recognized as a zoonotic virus.

Tricarboxylic Acid Cycle Metabolite-Coordinated Biohydrogels Augment Cranial Bone Regeneration Through Neutrophil-Stimulated Mesenchymal Stem Cell Recruitment and Histone Acetylation-Mediated Osteogenesis.

Cranial bone defects remain a major clinical challenge, increasing patients' life burdens. Tricarboxylic acid (TCA) cycle metabolites play crucial roles in facilitating bone tissue regeneration. However, the development of TCA cycle metabolite-modified biomimetic grafts for skull bone regeneration still needs to be improved.

Vascular and lymphatic heterogeneity and age-related variations of dental pulps.

Objectives: Dental pulp tissue is highly vascularized. However, age-related vascular changes of the dental pulp in mice and humans remain poorly understood. We modified a novel tissue clearing method, mapped the vasculature, pericytes, and perivascular matrix in the dental pulp via high-resolution 3D imaging.

Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies.

Hyperlipidemia refers to the abnormal increase in plasma lipid level exceeding the normal range. At present, a large number of patients require dental implantation. However, hyperlipidemia affects bone metabolism, promotes bone loss, and inhibits the osseointegration of dental implants through the mutual regulation of adipocytes, osteoblasts, and osteoclasts.