Pre-transplant compatibility testing: Transition from CDCXM to flow cytometry in India.

Over 60 % of kidney transplant candidates are non-sensitised while remaining 40 % are sensitised because of previous exposure to human alloantigens during previous transplants, blood transfusions, and pregnancy in women. Pre-transplant compatibility testing is mandatory prior to renal transplantation for detecting the presence of donor-specific antibodies (DSAs), which are associated with early hyperacute/acute and later chronic rejections. Initially, complement-dependent cytotoxicity crossmatch (CDCXM) was used as a traditional method for detecting preformed DSAs.

Oral Administration of GnRH and Domperidone via Gel Feed and Their Effect on Reproductive Performance of (Bengal Danio), an Ornamental Fish.

This study investigated the effects of dietary Gonadotropin-releasing hormone (GnRH) and domperidone on the reproductive performance of during a 40-day trial. Five treatment groups received varying doses of GnRH (100, 50, 25, 12.5 µg/kg body weight) in combination with domperidone (50, 25, 12.

Hepatitis B: Assessment of Knowledge, Attitude, and Practice among the Graduating Dental Students of Odisha: A Web-Based Survey.

Introduction: Evaluating the level of knowledge, attitude, and practice regarding Hepatitis B viral infection among the interns of dental colleges in Odisha.

Materials And Method: A questionnaire with 20 closed-ended questions was circulated to 269 interns in the dental colleges of Odisha. A total of 243 interns participated in the study and responded on various aspects of Hepatitis B viral infection including symptoms, transmission mechanisms, preventive measures, and immunization.

Study of human leukocyte antigen (HLA) allele and haplotype frequency using next generation sequencing (NGS) platform: Single-centre study of over 500 individuals in India!

Background: The huge diversity of Human Leukocyte Antigen (HLA) system is well-known to be associated with various diseases, anthropology, population genetics, and transplantation. The frequencies of HLA alleles in different populations are crucial for both research and clinical applications. This study determined the allelic and haplotype frequencies of all HLA class I and class II loci in 595 consecutive samples from patients who underwent solid organ transplantation (SOT) and hematopoietic progenitor cell transplantation (HPCT).

Severe Diffuse Ulcerative Esophagitis Caused by Epstein-Barr Virus/Cytomegalovirus Coinfection in an Immunocompetent Individual.

Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are important causes of viral esophagitis mainly in immunocompromised individuals. Both viruses lead to development of focal ulcerations in the esophagus. While there have been rare case reports of esophagitis in immunocompetent individuals, there has not been a single reported case of coinfection with both CMV and EBV in an immunocompetent individual and presenting with diffuse esophageal ulceration.

Overcoming Challenges and Innovations in Orthopedic Prosthesis Design: An Interdisciplinary Perspective.

Recent advances in the orthopedic prostheses design have significantly improved the quality of life for individuals with orthopedic disabilities. However, there are still critical challenges that need to be addressed to further enhance the functionality of orthopedic prostheses improving biocompatibility to promote better integration with natural tissues, enhancing durability to withstand the demands of daily use, and improving sensory feedback for better control of movement are the most pressing issues. To address these challenges, promising emerging solutions such as smart prosthetics, 3D printing, regenerative medicine, and artificial intelligence have been developed.

Sperm Cell Driven Microrobots-Emerging Opportunities and Challenges for Biologically Inspired Robotic Design.

With the advent of small-scale robotics, several exciting new applications like Targeted Drug Delivery, single cell manipulation and so forth, are being discussed. However, some challenges remain to be overcome before any such technology becomes medically usable; among which propulsion and biocompatibility are the main challenges. Propulsion at micro-scale where the Reynolds number is very low is difficult.

Synthesis, biological evaluation and corrosion inhibition studies of transition metal complexes of Schiff base.

Background: The transition metal complexes formed from Schiff base is regarded as leading molecules in medicinal chemistry. Because of the preparative availability and diversity in the structure of central group, the transition metals are important in coordination chemistry. In the present work, we have designed and prepared Schiff base and its metal complexes (MC-MC) and screened them for antimicrobial, anticancer and corrosion inhibitory properties.

Ultrasound assisted synthesis of biodiesel from karanja oil by interesterification: Intensification studies and optimization using RSM.

The present work deals with the optimization of interesterification of karanja oil using response surface methodology (RSM) analysis with intensification studies based on the use of ultrasound. Esterification of karanja oil was performed as a pretreatment under fixed optimum conditions of molar ratio of 1:10, catalyst loading of 3.5% and temperature of 60 °C to reduce the acid value from initial of 10.