Efficacy and safety of tafolecimab in Chinese patients with familial hypercholesterolemia: a systematic review and meta-analysis of randomized controlled trials.

Background: Familial hypercholesterolemia (FH) is a prevalent inherited disorder marked by elevated low-density lipoprotein cholesterol (LDL-C) levels, predisposing individuals to premature cardiovascular disease and related morbidities. Traditional treatments often fail to achieve target LDL-C levels in many patients, necessitating novel therapies. Tafolecimab, a monoclonal antibody targeting PCSK9, shows promise in managing HeFH by enhancing LDL receptor recycling and LDL-C clearance.

The association of COVID-19 with the development of acute avascular necrosis of the head of the femur, apart from steroid usage.

The SARS-CoV-2 pandemic (COVID-19) has significantly impacted global health, with emerging evidence indicating potential long-term complications affecting various organ systems, including the musculoskeletal system, like avascular necrosis (AVN) of the femoral head. This retrospective study aims to investigate the incidence and risk factors of AVN in patients treated for COVID-19. We conducted a cross-sectional retrospective study in the department of orthopedics at a tertiary care teaching hospital in Central India from July 2022 to December 2023.

Revolutionizing Utility of Big Data Analytics in Personalized Cardiovascular Healthcare.

The term "big data analytics (BDA)" defines the computational techniques to study complex datasets that are too large for common data processing software, encompassing techniques such as data mining (DM), machine learning (ML), and predictive analytics (PA) to find patterns, correlations, and insights in massive datasets. Cardiovascular diseases (CVDs) are attributed to a combination of various risk factors, including sedentary lifestyle, obesity, diabetes, dyslipidaemia, and hypertension. We searched PubMed and published research using the Google and Cochrane search engines to evaluate existing models of BDA that have been used for CVD prediction models.

Exploring the impact of electroconvulsive therapy on intracranial pressure: A study of optic nerve sheath diameter measurements.

ObjectiveThis study investigated the effects of Electroconvulsive Therapy (ECT) on intracranial pressure (ICP) by measuring the optic nerve sheath diameter (ONSD) using ultrasonography. While ECT is a common and effective treatment for various psychiatric disorders, its impact on cerebral hemodynamics, particularly ICP, remains unclear. Previous research suggests that ECT may increase cerebral blood flow and oxygen consumption, potentially elevating ICP.

Exploring Central Venous Thrombosis as a Rare Postinfectious Complication of Dengue: A Case Report.

Dengue fever, caused by a flavivirus transmitted through Aedes mosquitoes, presents a spectrum of clinical manifestations ranging from mild to severe. Several neurological complications, including encephalopathy and encephalitis, have been increasingly recognized. Here, we report a case of central venous thrombosis (CVT) as a postinfectious complication of dengue fever.

Prostate Artery Embolization for Benign Prostatic Hyperplasia: A Case Report and Comprehensive Literature Review.

This case report describes the successful use of prostate artery embolization (PAE) in a 75-year-old male with benign prostatic hyperplasia (BPH) and severe lower urinary tract symptoms (LUTS) that did not respond to medical therapy. Despite initial treatments, the patient had persistent symptoms and significant prostate enlargement. PAE was chosen for its minimally invasive nature and advantages over traditional surgery.

Prevalence of traditional cardiovascular risk factors in high-risk Kyrgyzstan population as compared to Indians - An Indo-Kyrgyz cardiometabolic study.

Background: Cardiovascular diseases (CVDs) are one of the most prevalent causes of mortality worldwide, especially significant in low- and middle-income countries. Kyrgyzstan and India represent such nations that face a huge burden of CVD-related deaths globally. Understanding the prevalence of traditional cardiovascular risk factors (CVRFs) in these populations is critical for effective prevention and management strategies.

Malignant Insulinoma: Diagnostic Difficulties and Treatment Strategies in a Case of Persistent Hypoglycemia.

Hypoglycemia in non-diabetic individuals is a rare but critical condition that often signals an underlying pathology. Insulinoma, a rare neuroendocrine tumor of the pancreas, is a key differential diagnosis. As the most common functional pancreatic neuroendocrine tumors, insulinomas originate from pancreatic islet cells and are predominantly benign.

Comprehensive surgical management of a severe 270-degree circumferential penetrating neck injury from an industrial accident: a case report.

Penetrating neck injury (PNI), involving disruption of the platysma muscle, accounts for 10% of trauma cases and poses significant morbidity and mortality risks. This case report details the management of a 45-year-old male who sustained a 270-degree circumferential neck incision from an industrial accident. The patient presented with a deep neck laceration, severe blood loss, and hypovolemic shock.