Investigating the mechanism of inositol against paclitaxel chemoresistance on triple-negative breast cancer by using 7T multiparametric MRI and mitochondrial changes.

Background: The emerging triple-negative breast cancer (TNBC) treatments target mitochondrial fission to combat paclitaxel (PTX) resistance. Inositol's inhibition of this process makes it a potential therapy. Multiparametric MRI provides an early and effective assessment of these innovations.

Advancing lithium metal batteries with polymerized PMMA-based elastomericelectrolytes.

A novel denture-inspired protocol for the preparation of poly(methyl methacrylate) (PMMA)-based solid-state elastomer electrolytes for lithium metal batteries (LMBs) has been reported in this work. The combination of succinonitrile and lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) as a deep eutectic electrolyte (DEE) enables efficient dissociation of Li from TFSI. Additionally, by optimizing the molar ratios of DEE and MMA to 2.

Detecting Changes in Reactive Oxygen Species in the Brain by GSH-Thiol-Weighted Imaging via Variable Delay Multipulse Chemical-Exchange Saturation Transfer.

: Detecting changes in reactive oxygen species (ROS) is critical for understanding its role in brain health and diseases. We assumed that GSH-thiol-weighted imaging could potentially reflect subtle changes in the ROS in the microenvironment. In this study, we aimed to investigate the capability of GSH-thiol-weighted imaging via VDMP-CEST in detecting alterations of ROS within the brain.