Celery and Spinach Flavonoid-Rich Extracts Enhance Phytoalexin Production in Powdery Mildew-Infected Cucumber Leaves.

Phytoalexins are antimicrobial compounds of diverse chemical classes whose production is triggered in plants in response to pathogen infection. This study demonstrated that spraying with a celery flavonoid-rich extract (CFRE) or a spinach flavonoid-rich extract (SFRE) enhanced the production of phytoalexins in cucumber leaves artificially infected with powdery mildew incited by . High-performance liquid chromatographic (HPLC) analysis revealed a noticeable increase in the content of phenolic acids, including caffeic acid, ellagic acid, ferulic acid, gallic acid, -coumaric acid, and syringic acid, as well as the flavonoid rutin in both non-inoculated and inoculated leaves of cucumber seedlings treated with CFRE and SFRE, compared to healthy untreated leaves used as a control.

Antifungal activity of polyphenolic compounds against fluconazole-susceptible and -resistant species.

Background And Objectives: The rapid emergence of resistant fungi is occurring worldwide, and this crisis has been attributed to the lack of new antifungal drug development. This issue emphasizes the need for innovation in finding novel antifungals. There is an increasing interest in using the natural products of plants with high biological activity as alternatives to synthetic drugs.

Chemical Composition, Physiological and Morphological Variations in subg. Populations in Response to Different Salinity Levels.

This study evaluated the salinity tolerance of five populations of subg. ( and ). The aims of the study were to assess essential oil components, as well as growth and physiological parameters of two species in response to salt stress.

Antifungal activity of almond () hull extracts against clinical isolates of .

Background And Purpose: Various attempts have been made to find potent and effective alternatives with natural origin and fewer side effects for the current antifungals. This study aimed to determine the antifungal effects of the Hydroalcoholic Extract (HE) and Lyophilized Extract (LE) of on clinical isolates of . Moreover, their effects were compared with fluconazole.

Induces Cancer Cell Death in Breast and Glioblastoma Cancer in 2D/3D Models and Suppresses Breast Cancer Stem Cells.

Overcoming drug resistance and specifically targeting cancer stem cells (CSCs) are critical challenges in improving cancer therapy. Nowadays, the use of novel and native medicinal plants can provide new sources for further investigations for this purpose. The aim of this study was to assess the potential of , an endemic plant with diverse medicinal applications, in suppressing and targeting cancer and cancer stem cells in glioblastoma and breast cancer.

Chemical Investigations in Mozaff. Leaves Based on Comprehensive Analytical Methods: LC-MS, SPME, and GC-MS Analyses.

Mozaff. is a species of Apiaceae endemic to the Zagros Mountains in Iran. In the present investigation, for the first time, the polyphenolic compounds and flavonoids of its leaves were determined by liquid chromatography-mass spectrometry (LC-MS).

Bioassay-guided isolation in Karel. stem based on its anti-fungal and anti-trichomonas activity.

Background And Purpose: is considered a medicinal plant and has a broad distribution in Iran. In Iran's traditional medicine, it is also used to treat leishmaniasis, malaria, atherosclerosis, cardiovascular disease, and as a disinfectant. This research aimed to determine the anti- component from and anti- natural compounds from the stems of this plant.

Identification of Polyphenolic Compounds Responsible for Antioxidant, Anti- Activities and Nutritional Properties in Different Pistachio ( L.) Hull Cultivars.

The use of by-products from the agri-food industry is a promising approach for production of value-added, polyphenol-rich dietary supplements or natural pharmaceutical preparations. During pistachio nut processing, a great amount of husk is removed, leaving large biomass for potential re-use. The present study compares antiglycative, antioxidant, and antifungal activities as well as nutritional values of 12 genotypes belonging to four pistachio cultivars.

Essential Oil Composition and Antioxidant Activity of Oregano and Marjoram as Affected by Different Light-Emitting Diodes.

Oregano and marjoram are important aromatic spices in the food industry, as well as medicinal plants with remarkable antioxidant properties. Despite their popularity, little is known about treatments that would influence the antioxidant capacity of essential oils. In this study, different spectra of LED light, namely blue, red, white, blue-red, and natural ambient light as a control, were applied to assess the essential oil content, composition, flavonoid, phenolic, and antioxidant capacity of oregano and marjoram.

Changes in Essential Oil Composition, Polyphenolic Compounds and Antioxidant Capacity of Ajowan ( L.) Populations in Response to Water Deficit.

Ajowan ( L.) is considered a valuable spice plant with a high thymol content. Seed yield, essential oil constituents, polyphenolic composition, and antioxidant capacity of ajowan ( L.

Herbal Medicines as Potential Inhibitors of SARS-CoV-2 Infection.

Coronavirus disease 2019 (COVID-19) is the result of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Understanding molecular pathogenesis is an essential factor for the allocation of effective preventive measures and the development of targeted therapeutics against COVID-19. The genome of SARS-CoV-2 encodes structural and nonstructural proteins, which can be targets for compounds with potential therapeutic ability.

Foliar spray of commercial seaweed and amino acid-derived biostimulants promoted phytoremediation potential and salinity stress tolerance in halophytic grass, .

Plants pretreatment with various chemicals has often been used to diminish salinity stress impact on plants. An experiment was carried out to determine the effect of foliar spray of two commercially available biostimulants (Algabon [0.5 g/l] and Bonamid [2 g/l]) on the growth and tolerance of halophytic grass, under non-salinity condition (NSC) and salinity condition (SC).

In vitro activity of juglone (5-hydroxy-1,4-naphthoquinone) against both fluconazole-resistant and susceptible Candida isolates.

Background: The rise in antifungal resistance and drug class limitations are causing higher morbidity and mortality rates all over the world. This issue highlights the urgent need for new and improved antifungal drugs with a novel target.

Aims: In order to evaluate whether juglone can be served as an alternative antifungal to cure drug-resistant Candida infections, we studied the in vitro susceptibility of juglone against fluconazole-susceptible and -resistance Candida isolates, alone and in combination.

Pretreatment with LEDs regulates antioxidant capacity and polyphenolic profile in two genotypes of basil under salinity stress.

In the present study, we evaluated a pretreatment with four LED light sources (red, blue, red + blue, and white) in two genotypes (green and purple) of basil on the growth parameters, stress oxidative markers, non-enzymatic antioxidants, osmoprotectant compounds, ion content, and polyphenolic profile under both control and salinity stress conditions. The results indicated that 150 mM of NaCl decreased biomass, RWC, and K/Na ratio but increased the content of proline and antioxidant capacity in the leaves of both genotypes of basil grown under GH (greenhouse) conditions. The results suggested that RB LED-exposed plants in the green genotype and R LED-exposed plants in the purple genotype improved accumulation of shoot biomass, K/Na ratio, proline and soluble sugars, glutathione and ascorbate, polyphenolic profile, and thioredoxin reductase activity in the leaves of basil under both control and salinity stress conditions.

Metabolomics and DNA-Based Authentication of Two Traditional Asian Medicinal and Aromatic Species of subg. .

Subgenus of the extended genus of comprises several Central Asian medicinal and aromatic species, of which and are the most widespread. These plants are cultivated in Europe as robust ornamentals, and several cultivars are available. However, their medicinal potential remains underutilized because of limited information about their phytochemical and genetic diversity.

The effect of drought stress on polyphenolic compounds and expression of flavonoid biosynthesis related genes in Achillea pachycephala Rech.f.

This study investigated the effect of drought stress on the amount of phenolic and flavonoid compounds as well as HO and malondialdehyde (MDA) in Achillea pachycephala. The expression patterns of the key genes and their molecular mechanisms in the phenylpropanoid pathway (PAL, CHS, CHI, F3H, F3'H, F3'5'H, FLS) were also assessed during drought stress using quantitative real-time polymerase chain reaction (qRT-PCR). The samples were harvested at 0, 7, 14, 21 and 28 days after exposure to drought stress.

Effect of Drought Stress on Total Phenolic, Lipid Peroxidation, and Antioxidant Activity of Achillea Species.

The changes in total phenolic content (TPC), total flavonoid content (TFC), proline, malondialdehyde (MDA), H2O2, and antioxidant activity were assessed based on three model systems in three Achillea species (Achillea millefolium, A. nobilis, and A. filipendulina) growing under four irrigation regimes, including 100% FC (field capacity as normal irrigation) 75% FC (low stress), 50% FC (moderate stress), and 25% FC (severe stress) conditions.