Endophytic fungi: A future prospect for breast cancer therapeutics and drug development.

Globally, breast cancer is a primary contributor to cancer-related fatalities and illnesses among women. Consequently, there is a pressing need for safe and effective treatments for breast cancer. Bioactive compounds from endophytic fungi that live in symbiosis with medicinal plants have garnered significant interest in pharmaceutical research due to their extensive chemical composition and prospective medicinal attributes.

Molecular authentication, metabolite profiling and in silico-in vitro cytotoxicity screening of endophytic from for breast cancer therapeutics.

Unlabelled: In the present study, we isolated a potent endophytic fungus from the roots of . The endophytic fungal strain was authenticated as SVWS3 based on morphological and molecular sequencing using four gene data and phylogenetic analyses. In vitro cytotoxicity studies unveiled the remarkable cytotoxic potential of the crude extract derived from , exhibiting dose-dependent effects on MDA-MB-468 and MCF-7 cells.

Determinants of durable humoral and T cell immunity in myeloma patients following COVID-19 vaccination.

Objective: To describe determinants of persisting humoral and cellular immune response to the second COVID-19 vaccination among patients with myeloma.

Methods: This is a prospective, observational study utilising the RUDYstudy.org platform.

Prospective Assessment of Tumour Burden and Bone Disease in Plasma Cell Dyscrasias Using DW-MRI and Exploratory Bone Biomarkers.

Novel biomarkers for tumour burden and bone disease are required to guide clinical management of plasma cell dyscrasias. Recently, bone turnover markers (BTMs) and Diffusion-Weighted Magnetic Resonance Imaging (DW-MRI) have been explored, although their role in the prospective assessment of multiple myeloma (MM) and monoclonal gammopathy of undetermined significance (MGUS) is unclear. Here, we conducted a pilot observational cohort feasibility study combining serum BTMs and DW-MRI in addition to standard clinical assessment.

A Cross-Sectional Study of the Association of ABO Blood Group and Rh Type With Severity of COVID-19 Infection in a Tertiary Care Center of South India.

Background The novel coronavirus disease 2019 (COVID-19) was declared a pandemic that had affected 224 countries, causing >2.1 million deaths worldwide. The association of the different ABO blood groups with the risk and severity of COVID-19 infections has been speculated in many studies.

Leads and hurdles to sustainable microbial bioplastic production.

Indiscriminate usage, disposal and recalcitrance of petroleum-based plastics have led to its accumulation leaving a negative impact on the environment. Bioplastics, particularly microbial bioplastics serve as an ecologically sustainable solution to nullify the negative impacts of plastics. Microbial production of biopolymers like Polyhydroxyalkanoates, Polyhydroxybutyrates and Polylactic acid using renewable feedstocks as well as industrial wastes have gained momentum in the recent years.

Immune response to COVID-19 vaccination is attenuated by poor disease control and antimyeloma therapy with vaccine driven divergent T-cell response.

Myeloma patients frequently respond poorly to bacterial and viral vaccination. A few studies have reported poor humoral immune responses in myeloma patients to COVID-19 vaccination. Using a prospective study of myeloma patients in the UK Rudy study cohort, we assessed humoral and interferon gamma release assay (IGRA) cellular immune responses to COVID-19 vaccination post second COVID-19 vaccine administration.

Understanding health anxiety in the COVID-19 pandemic.

Background: The COVID-19 pandemic continues to be one of the greatest public health challenges faced by the UK. Reported rates of psychiatric difficulties have increased and the mechanisms by which the pandemic has affected mental health requires investigation.

Aims: The aim of the study was to understand the psychological impact of the COVID-19 pandemic on health anxiety in the general population, with a focus on Oxford Health NHS Foundation Trust, which provides specialist mental health care within Oxfordshire and Buckinghamshire.

Characterization of the major antifungal extrolite from rice endophyte Lysinibacillus sphaericus against Rhizoctonia solani.

Sheath blight of rice caused by Rhizoctonia solani is regarded as one of the most widely distributed diseases of rice, and is one of the major production constraints for rice in India and most rice-growing countries of Asia. Biological control of plant diseases using antagonistic bacteria is now considered as a promising alternative to the use of hazardous chemical fungicides or bactericides. Several bacterial endophytes have been reported to support growth and improve the health of the plants and therefore, may be important as biocontrol agents.

Induction of defence response in Oryza sativa L. against Rhizoctonia solani (Kuhn) by chitosan nanoparticles.

Rice is a major food source for more than half of the world population. It is the only crop whose cultivation utilizes large area of land for food production. Recent surveys on rice production revealed that its potential yield has drastically reduced and its demand has exceeded over its production.

Sequence analysis and docking performance of extracellular chitinase from Bacillus pumilus MCB-7, a novel mangrove isolate.

Bacterial chitinases has a major role in chitinaceous waste management, biological control of pests and phytopathogens. In the present study, exochitinase gene ChitA encoding extracellular chitinase from the mangrove bacteria Bacillus pumilus MCB-07 was genetically characterized. Oligonucleotide primers specific to chitinase gene of Bacillus pumilus were designed and amplified by PCR.

Exploring the efficacy of antagonistic rhizobacteria as native biocontrol agents against tomato plant diseases.

As the environmental and health concerns alert the necessity to move towards a sustainable agriculture system, biological approach using indigenous plant growth-promoting rhizobacteria (PGPR) gains a strong impetus in the field of plant disease control. In this context, the present review article addresses the usage of rhizospheric antagonistic bacteria as a suitable alternative to control tomato fungal diseases namely Fusarium wilt and early blight disease. Biological control has been considered to be an eco-friendly, safe and effective method for disease management.

Enhancing Activity by Supercritical CO Mediated Immobilization of Lipase on Mesocellular Foam in Preparation of Hexyl Laurate.

Hexyl laurate is employed in several cosmetics having great demand. It could be synthesized catalytically like a "natural" perfume using a lipase. The use of mesocellular foam silica (MCF) for immobilization of lipases could be made using supercritical CO as a medium to enhance its activity in comparison with the normal techniques.

Removal of Selected Pharmaceuticals and Personal Care Products from Wastewater using Soybean Peroxidase.

Personal care products and pharmaceuticals have been reported in various concentrations in the effluent of municipal sewage treatment plants (STP). Although they are generally found in the nanogram to microgram per liter range, many of them might have adverse health effects on humans at these concentrations. Conventional treatments applied at the STP are unable to effectively remove most of these recalcitrant compounds, thus there is a necessity for development of alternative treatment techniques.

Nitrogen fixing bacterial diversity in a tropical estuarine sediments.

Microorganisms play a significant role in biogeochemical cycles, especially in the benthic and pelagic ecosystems. Role of environmental parameters in regulating the diversity, distribution and physiology of these microorganisms in tropical marine environment is not well understood. In this study, we have identified dinitrogen (N) fixing bacterial communities in the sediments by constructing clone libraries of nitrogenase (nifH) gene from four different stations in the Cochin estuary, along the southeastern Arabian Sea.

An assessment of potential public health risk associated with the extended survival of indicator and pathogenic bacteria in freshwater lake sediments.

Microcosm studies were performed to evaluate the survival of Escherichia coli, Salmonella paratyphi and Vibrio parahaemolyticus in water and sediment collected from the freshwater region of Vembanad Lake (9'35 °N 76'25 °E) along the south west coast of India. All three test microorganisms showed significantly (p < 0.01) higher survival in sediment compared to overlying water.

Increased prevalence of indicator and pathogenic bacteria in Vembanadu Lake: a function of salt water regulator, along south west coast of India.

Prevalence of faecal indicator bacteria, Escherichia coli and pathogenic bacteria, Vibrio cholerae, Vibrio parahaemolyticus and Salmonella were analysed in Vembanadu lake (9 degrees 35'N 76 degrees 25'E), along south west coast of India for a period of one year from ten stations on the southern and northern sides of a salt water regulator constructed in Vembanadu Lake in order to prevent incursion of seawater during certain periods of the year. While the northern side of the lake has a connection to the sea, the southern side is enclosed when the salt water regulator is closed. The results revealed the water body is polluted with high faecal coliform bacteria with mean MPN value ranging from 1718-7706/100 ml.

Prevalence of Multiple Drug Resistant Escherichia coli Serotypes in a Tropical Estuary, India.

A total of eighty-one Escherichia coli isolates belongs to forty-three different serotypes including several pathogenic strains such as enterotoxigenic E. coli (ETEC), enterohaemorrhagic E. coli (EHEC), enteropathogenic E.