Synthesis, human carbonic anhydrase I and II inhibition, and in silico studies of 2-ethoxy-6-formylphenyl [1,1'-biphenyl]-4-sulfonate derived thiosemicarbazones.

This study describes the synthesis and biological evaluation of 2-ethoxy-6-formylphenyl [1,1'-biphenyl]-4-sulfonate-based thiosemicarbazones 5(a-s) as potential inhibitors of human carbonic anhydrase isoforms hCA I and hCA II. Among the synthesized compounds, 5 k exhibited potent inhibition, with IC values of 89.25 nM and 54.

Supracondylar Dome Osteotomy for Post-traumatic Cubitus Varus in Children: A Retrospective Study.

Objective: Cubitus varus is a frequent sequela of pediatric supracondylar humerus fractures and presents with varus malalignment, extension, and internal rotation of the elbow. Although often regarded as a cosmetic deformity, it can lead to significant functional impairments, including chronic pain, ulnar nerve palsy, and posterolateral elbow instability.We retrospectively analyzed the effectiveness of supracondylar dome osteotomy in restoring alignment and function in children with post-traumatic cubitus varus.

DNA Methylation: A Key Regulator in Male and Female Reproductive Outcomes.

DNA methylation is a well-studied epigenetic modification that regulates gene expression, maintains genome integrity, and influences cell fate. It is strictly regulated by a group of enzymes known as DNA methyltransferases (DNMTs). Most DNA methylation occurs at cytosines within symmetrical CpG dinucleotide base pairs, often located at gene promoters or other regulatory elements.

Computational Study of Pathogenic Variants in Phenylalanine-4-hydroxylase (PAH): Insights into Structure, Dynamics, and BH Binding.

The phenylalanine-4-hydroxylase (PAH) gene encodes the PAH enzyme, which is necessary for the conversion of l-phenylalanine (l-Phe) to l-tyrosine (l-Tyr). Deleterious mutations in PAH can disrupt its function, leading to the toxic buildup of phenylalanine in the brain and causing the inherited genetic disorder phenylketonuria (PKU). This condition results in behavioral issues, epilepsy, and intellectual disability.

Radioactivity distribution and concomitant hazards evaluation of industrial zones soils from Chattogram, Bangladesh: A multivariate statistical analysis.

Soil can pose significant radiation hazard in areas with elevated radioactivity levels from geological or anthropogenic sources, potentially contributing to human exposure through the food chain and atmosphere. However, industrial activities can alter radionuclides distribution by releasing residues or effluents, leading to their accumulation in the environment. In general, soil provides clear insights into geological characteristics and heavy metal exploration, in addition to assessing the risks of radiation exposure.

Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances.

The most aggressive subtype of breast cancer is triple-negative breast cancer (TNBC), which affects about 10-15% of all breast cancer cases. TNBC is associated with a poor prognosis and drug resistance due to the lack of oestrogen, progesterone, and HER2 receptors. Developing targeted immunotherapy for TNBC was challenged by identifying TNBC-specific antigens that can be suitable targets for antibody and nanobody-based therapies.

Examining the relationship between social deprivation index and pedestrian injuries in a suburban setting: Is that the only factor?

Background: Increased efforts to understand the reasons for the rise in pedestrian related traffic fatalities have demonstrated that these injuries occur in minority and lower income neighborhoods. The purpose of our study was to characterize the patient population suffering from pedestrian injuries in suburban setting, to determine whether the incidence of pedestrian injuries is associated with the social deprivation index (SDI) and to identify zip codes with a higher incidence of pedestrian injuries.

Methods: Single center, descriptive, retrospective cohort study of all patients suffering from pedestrian injuries admitted to our Level I Trauma Center (01/2014-10/2022).

From Warm to Cold: Feeding Cold Milk to Preterm Infants with Uncoordinated Oral Feeding Patterns.

: Premature infants frequently experience feeding difficulties due to the disrupted coordination of sucking, swallowing, and breathing, increasing the risk of airway compromise. In adults with dysphagia, cold liquids can enhance swallowing by stimulating sensory receptors in the pharyngeal mucosa. We previously demonstrated that short-duration feeding with cold liquid significantly reduces dysphagia in preterm infants; however, the impact of an entire feeding with cold milk remains unexplored.

Mechanisms by which phytogenic extracts enhance livestock reproductive health: current insights and future directions.

Reproductive health is a critical determinant of livestock productivity and economic sustainability. However, it is often compromised by infectious diseases, environmental stressors, and nutritional deficits. Phytogenic extracts-bioactive compounds derived from medicinal plants-have emerged as sustainable alternatives to synthetic antibiotics and hormones, exhibiting antimicrobial, antioxidant, and immunomodulatory properties.

Effective interscan time for enhanced choriocapillaris imaging with OCT angiography.

Despite advancements in optical coherence tomography angiography (OCTA), imaging of the choriocapillaris (CC) remains challenging due to its dense microvascular structure and low reflectivity. While previous studies have explored various scanning protocols to enhance CC visualization, most approaches rely on oversampling, beam size adjustments, large numbers of repetitive B-scans (BM), and volume registration. However, interscan time-a critical parameter that influences flow contrast and vascular detail-has been largely overlooked.

Near-Hanging Injuries: Perspective for the Trauma and Emergency Surgeon.

Near-hanging injuries are a significant cause of morbidity and mortality worldwide. These injuries result in complex clinical presentations due to the combination of mechanical asphyxia and potential neck and cervical spine trauma. The primary objectives of this narrative review include assessing the incidence, sex distribution, pathophysiology, prognostic indicators, neurologic outcomes, and treatment strategies.

Developing a Computable Phenotype for Identifying Children, Adolescents, and Young Adults With Diabetes Using Electronic Health Records in the DiCAYA Network.

Objective: The Diabetes in Children, Adolescents, and Young Adults (DiCAYA) network seeks to create a nationwide electronic health record (EHR)-based diabetes surveillance system. This study aimed to develop a DiCAYA-wide EHR-based computable phenotype (CP) to identify prevalent cases of diabetes.

Research Design And Methods: We conducted network-wide chart reviews of 2,134 youth (aged <18 years) and 2,466 young adults (aged 18 to <45 years) among people with possible diabetes.

A sustainable approach to develop antimicrobial composite film incorporating novel Dalbergia reniformis seed-derived microcrystalline cellulose and medicinal Mikania micrantha extract in PVA.

This study presents a sustainable approach to develop antimicrobial films (AMFs) using agricultural wastes. Microcrystalline cellulose (MCC) was extracted from a novel source of Dalbergia reniformis seeds (DRS) through chemical hydrolysis, and bioactive powder from Mikania micrantha (MM) leaves was reinforced into a polyvinyl alcohol (PVA) matrix to create antimicrobial films. The morphological, antimicrobial, physical, mechanical, and thermal properties of the films were investigated.

Vitexin's Role in Colon Cancer Apoptosis: AMPK/mTOR Pathway Modulation Explored Through Experimental and Computational Approaches.

Background: Colorectal cancer is a significant global public health challenge, contributing substantially to cancer-related mortality worldwide. Vitexin has been shown to promote the polarization of macrophages towards the M1 phenotype, a process dependent on the Vitamin D receptor. This polarization is crucial in the tumor microenvironment, as it helps mitigate the progression from chronic colitis to colorectal cancer.

Sixty hertz STN-DBS and L-Dopa reduces gait variability in parkinson's disease.

Objective: We investigated the effects of Subthalamic Deep Brain Stimulation (STN-DBS) at high (180hz) and low frequency (60hz) and L-dopa on variability of spatiotemporal gait measures in an advanced PD cohort.

Materials And Methods: This study consisted of PD subjects with chronic bilateral STN-DBS. Each combination of medication state (OFF/ON) and stimulation frequency (60 Hz/180Hz) were assessed and randomized across electrode contacts.

Perspectives of Hospital Medicine Providers on the Management of Oropharyngeal Dysphagia in Patients with Dementia.

Background: Oropharyngeal dysphagia (dysphagia) is a common (up to 86%) and devastating syndrome in hospitalized older adults with dementia.

Objective: To describe the perspectives of dysphagia management in hospitalized patients with dementia among hospital medicine providers (i.e.

Detection, characterization, and antibiotic resistance profiling of multidrug-resistant bacteria isolated from circulating currency in the Northeastern region of Bangladesh.

Objectives: The study aims to investigate the prevalence of multidrug resistant bacteria on paper and coin currency obtained from various occupational groups in Bangladesh and to identify the bacterial species present. The research further seeks to evaluate the antibiotic resistance patterns of the identified bacterial isolates.

Methods: 84 paper currency notes and 56 coins were collected from seven different sources.

Role of mordants in natural fabric dyeing and their environmental impacts.

The textile industry is undergoing a transformative shift towards sustainability, driven by mounting environmental concerns and consumer demand for eco-friendly products. This review article explores the use of mordants in textile dyeing processes, encompassing both traditional metal mordants and emerging bio-mordants. Metal mordants, commonly used in textile dyeing, present environmental challenges due to their toxic nature.

Wheat arabinoxylans: Insight into structure-function relationships.

Arabinoxylan (AX), a key non-starch polysaccharide found in the cell walls of cereals like wheat, holds significant importance in the food industry. Recently, it has attracted attention due to its numerous health benefits. While the benefits of wheat arabinoxylans are well-established, a more comprehensive understanding of the relationship between their structure and functional properties is essential.

Benzylidenehydrazine Derivatives: Synthesis, Antidiabetic Evaluation, Antioxidation, Mode of Inhibition, DFT and Molecular Docking Studies.

Diabetes mellitus (DM) is a metabolic condition that is a profound health concern across the globe due to its contribution to the increased mortality rate. It affects millions of people around the world and is associated with severe complications among people diagnosed with it. Among the array of approaches used for the management of DM, inhibition of enzymes viz.

Single-Shot Ultra-Widefield Polarization-Diversity Optical Coherence Tomography for Assessing Retinal and Choroidal Pathologies.

: Optical coherence tomography (OCT) is a leading ocular imaging modality, known for delivering high-resolution volumetric morphological images. However, conventional OCT systems are limited by their narrow field-of-view (FOV) and their reliance on scattering contrast, lacking molecular specificity. : To address these limitations, we developed a custom-built 105 ultra-widefield polarization-diversity OCT (UWF PD-OCT) system for assessing various retinal and choroidal conditions, which is particularly advantageous for visualizing peripheral retinal abnormalities.

Splitting and authentication of the newest retrieved cellulose-rich organic fiber from the exterior layer of Bangladeshi palmyra seed sprouts.

The upward trajectory of plant-based cellulosic fiber originating from renewable sources is crucial to visualizing a sustainable future. This article reports a freshly developed and distinctive natural fiber derived from palmyra seed sprout fibers (PSSF) by employing hot water retting. The hygroscopic behavior (moisture regain and content) density, bundle fiber strength, burning behavior, and chemical composition of the fiber are determined using ASTM D1909, ASTM D2654, ASTM D891-18, ASTM D1445, ASTM D1230-22, and TAPPI standards, respectively.