Design, Synthesis, and Evaluation of Novel Quinazolin-4(3H)-One Derivatives: Anti-Leishmanial Activity, Selectivity, and Molecular Docking Insights.

In this study, 16 novel quinazolin-4(3H)-one derivatives were synthesized and evaluated for their antileishmanial activity against Leishmania major and Leishmania donovani. Among them, compounds 2 (4-hydroxy substituted) and 9 (4-morpholino substituted) exhibited the highest efficacy, with compound 2 showing IC values of 23.94 μM for L.