Design, Synthesis, and Evaluation of Novel Quinazolin-4(3H)-One Derivatives: Anti-Leishmanial Activity, Selectivity, and Molecular Docking Insights.

In this study, 16 novel quinazolin-4(3H)-one derivatives were synthesized and evaluated for their antileishmanial activity against Leishmania major and Leishmania donovani. Among them, compounds 2 (4-hydroxy substituted) and 9 (4-morpholino substituted) exhibited the highest efficacy, with compound 2 showing IC values of 23.94 μM for L.

The role of complement system in a gerbil model of cutaneous leishmaniasis.

Leishmania species are intracellular protozoans responsible for causing both cutaneous and visceral infections. In recent years, the prevalence of leishmaniasis, a systemic and chronic disease, has been on the rise. Complement pathway mechanisms, part of the immune response of host organisms against Leishmania species, have not been fully revealed in leishmaniasis, which is very important for public health.

Immunopathological investigation of a gerbil model of cutaneous leishmaniasis.

Leishmaniasis, caused by Leishmania species (intracellular protozoans), is a chronic, systemic disease that causes skin (cutaneous) and internal organ infections (visceral). Its prevalence has increased in recent years. Leishmania species are considered important pathogens that affect public health.