Sleep-promoting effects and potential mechanisms of Apocynum venetum leaf extract (VENETRON®): Effects of acute and chronic treatment on the sleep-wake profiles in mice.

Ethnopharmacological Relevance: Apocynum venetum L. has long been used to promote relaxation and alleviate anxiety. It has been prescribed to treat insomnia, reduce psychological stress, and support overall well-being.

The polyphenol/caffeine ratio determines the arousal-inducing properties of the green tea ethanol extract.

Green tea ( L.), one of the most popular beverages worldwide, contains caffeine, a natural stimulant. However, some green tea extracts have been known to possess both hypnotic and arousal effects.

Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study.

Background: Citrus peels are rich in flavonoids with potential sedative-hypnotic effects; however, these effects have not yet been fully explored. We previously demonstrated that, in mice, standardized lime peel supplement (SLPS) induced non-rapid eye movement sleep and shortened sleep latency through GABA receptors activation.

Purpose And Study Design: This study aimed to evaluate the effects of SLPS in adults experiencing sleep disturbances.

Optimization of Desalting Conditions for the Green Seaweed for Use as a Functional Food with Hypnotic Effects.

(CF) contains various bioactive compounds, but its high salt content (39.8%) makes its use as a functional food challenging. Here, we aimed to optimize the desalination process and verify changes in functionality based on variations in salt and total phenolic contents.

Novel neuropharmacological activity of citrus lime (Citrus aurantifolia): A standardized lime peel supplement enhances non-rapid eye movement sleep by activating the GABA type A receptor.

Polyphenols have been well-established to exert sedative-hypnotic effects in psychopharmacology. Lime (Citrus aurantifolia) peel is rich in biologically active polyphenols; however, the effects of lime peel extract on sleep have not yet been demonstrated. A comparison was conducted in mice, between the sleep-promoting effects of a standardized lime peel supplement (SLPS) and a well-known hypnotic drug, zolpidem, and its hypnotic mechanism was investigated using in vivo and in vitro assays.

Effects of Chronic Administration of Green Tea Ethanol Extract on Sleep Architecture in Mice: A Comparative Study with a Representative Stimulant Caffeine.

Wakefulness is defined as a state in which individuals can react to a change in situations. The number of people staying awake and compensating for lack of sleep has increased in recent years. Caffeine, a representative stimulant, is the most extensively consumed compound globally and is mainly consumed through coffee.

Marine Polyphenol Phlorotannins as a Natural Sleep Aid for Treatment of Insomnia: A Review of Sedative-Hypnotic Effects and Mechanism of Action.

Insomnia is a common sleep disorder. Natural sleep aids are gaining worldwide popularity as alternatives to prescription drugs for improving sleep. Recently, numerous studies have investigated the sedative-hypnotic effects of the polyphenols of terrestrial plants.

Curcuminoids, a major turmeric component, have a sleep-enhancing effect by targeting the histamine H1 receptor.

Turmeric () had been considered as a universal panacea in functional foods and traditional medicines. In recent, the sedative-hypnotic effect of turmeric extract (TE) was reported. However, sleep-promoting compounds in TE have been not yet demonstrated.

Preventive Measures Against COVID-19 in Small- and Mid-sized Enterprises from an Early Stage of the Epidemic in Daegu and Gyeongsangbuk-do.

Background: In the early stage of the coronavirus disease 2019 (COVID-19) epidemic, small- and mid-sized enterprises (SMEs) may be an important transmission consideration. The study aimed to identify the pattern of COVID-19 prevention measures during the outbreaks in Daegu and Gyeongsangbuk-do at the early stage of COVID-19. Moreover, we investigated whether SME size and past experiences affected the preventive measures implemented in the region.

Arousal-Inducing Effect of Peel Extract in Pentobarbital-Induced Sleep Test and Electroencephalographic Analysis.

Caffeine, a natural stimulant, is known to be effective for weight loss. On this basis, we screened the arousal-inducing effect of five dietary supplements with a weight loss effect (, , L., , and M.

Effects of Thermal Treatment on the Physical Properties of Edible Calcium Alginate Gel Beads: Response Surface Methodological Approach.

Calcium alginate gel (CAG) has been widely investigated for the development of artificial foods; however, there are few studies on its thermal stability. This study aimed to monitor changes in the physical properties of CAG beads during heat treatment using response surface methodology. Heating temperature (X, 40-100 °C) and heating time (X, 5-60 min) were chosen as independent variables.

Multi-field merit-function-based regression method for Wide Field Infrared Survey Telescope grism system alignment.

The grating prism (grism), slitless spectrometer aboard the Wide Field Infrared Survey Telescope enables a survey of emission-line galaxies. To facilitate its opto-mechanical alignment, a six-degree-of-freedom element was fabricated using alignment fiducials and integral flats and used to measure a wavefront by using an infrared interferometer placed at various field points over a 20×14  deg field of view in the grism coordinate frame. Modeling identified E2 to be the most sensitive element to the grism wavefront error and was used to efficiently align the system.

Merit function regression method for efficient alignment control of two-mirror optical systems.

The precision alignment of high-performance, wide-field optical systems is generally a difficult and often laborious process. We report a new merit function regression method that has the potential to bring to such an optical alignment process higher efficiency and accuracy than the conventional sensitivity table method. The technique uses actively damped least square algorithm to minimize the Zernike coefficient-based merit function representing the difference between the designed and misaligned optical wave fronts.