A 12-year nationwide cohort study on the association between central retinal artery occlusion and cancer.

Purpose: This study aims to investigate the association between incident central retinal artery occlusion (CRAO) and the subsequent development of cancer.

Methods: We included incident CRAO patients from the 2002-2013 National Health Insurance Service database in South Korea. For the patient cohort, we included patients diagnosed with CRAO from the database, and excluded patients having CRAO or any cancer history during the first 2-year washout period (2002-2003).

Antihypertensive Use and the Risk of Cataract in Patients with Hypertension: A Nationwide Case-control Study.

Purpose: This study aims to investigate the association between antihypertensive use and the risk of cataract in a matched case-control study.

Methods: We analysed the Korean National Health Insurance Service-Health Screening Cohort database from 2002 to 2013. We defined 'cases' as patients prescribed antihypertensives and underwent their first eye cataract surgery between 2010 and 2013.

Fracture risk and impact of osteoporosis in patients with Parkinson's disease: a nationwide database study.

Introduction: Patients with Parkinson's disease (PD) showed an increased risk of fractures in previous studies and a high prevalence of osteoporosis is reportedly a potential contributor. We conducted a nationwide database study on the risk of fractures and the impact of osteoporosis on patients with PD compared to controls.

Materials And Methods: Using a nationwide database in South Korea, we identified incident patients with PD in 2004-2006 and selected four age- and sex-matched controls.

Statin use and pneumonia risk in Parkinson's disease.

Introduction: Previous studies reported that statin use was related to a lower risk of pneumonia in the general population. This study investigated the association between statin use and pneumonia risk in patients with Parkinson's disease (PD).

Methods: Patients that had been newly diagnosed with PD between 2004 and 2006 in the 2002-2017 National Health Insurance Service database in South Korea were identified.

Risk and mortality of aspiration pneumonia in Parkinson's disease: a nationwide database study.

This retrospective cohort study investigated the risk and mortality rate due to aspiration pneumonia in patients with Parkinson's disease (PD) using a nationwide database. We identified 10,159 newly diagnosed PD patients between 2004 and 2006, and four age- and sex-matched controls for each PD patient from the National Health Insurance Service database in Korea. We analyzed the relative risk of aspiration pneumonia and mortality after the first occurrence of aspiration pneumonia until 2017.

Assessment of Trends in the Incidence Rates of Central Retinal Artery Occlusion in Korea From 2002 to 2015.

Importance: Central retinal artery occlusion (CRAO) is associated with and shares common risk factors with cardiovascular diseases. Over the past several decades, the incidence rates of stroke and ischemic heart disease have substantially decreased in high-income industrialized countries. However, little is known regarding current trends in CRAO incidence rates.

Ten-Year Relative Survival From the Diagnosis of Parkinson's Disease: A Nationwide Database Study.

Objectives: Varying early survival rates have been reported across studies on patients with Parkinson's disease (PD). In this study, we reported the 10-year relative survival rate of patients with PD using a nationwide database.

Design: This was a population-based cohort study.

Twelve-year incidence of retinal vein occlusion and its trend in Korea.

Purpose: To estimate the 12-year incidence and trends of clinically diagnosed retinal vein occlusion (RVO) in Korea.

Methods: This is a nationwide population-based retrospective study using the Korean national health claims database from 2002 to 2015. The study consisted of the entire Korean population based on the 2015 Census of Population.

Cardiovascular risk in patients receiving ranibizumab for exudative age-related macular degeneration: a nationwide self-controlled case-series study.

Aims: To identify the association between ranibizumab and risk of stroke and acute myocardial infarction (AMI) in patients with exudative age-related macular degeneration (AMD).

Methods: We identified patients aged ≥45 years who received ranibizumab for exudative AMD from the Korean National Health Insurance database. Of these, we selected patients suffering stroke or AMI for the self-controlled case series.

Pneumonia risk and its associated factors in Parkinson's disease: A National Database Study.

Background: Despite pneumonia being an emerging burden on Parkinson's disease patients, there is essentially nothing known on whether they are at an increased risk of pneumonia occurrence and their associated factors.

Objectives: To determine whether Parkinson's disease is associated with the risk of pneumonia and its associated factors.

Methods: Using nationwide database that covers the whole population in South Korea from 2002 to 2017, we identified newly diagnosed Parkinson's disease patients in 2004-2006, and selected four age- and sex-matched controls for each patient from the general population.

Effects of Hypertension, Diabetes, and Smoking on Age and Sex Prediction from Retinal Fundus Images.

Retinal fundus images are used to detect organ damage from vascular diseases (e.g. diabetes mellitus and hypertension) and screen ocular diseases.

Association Between Acetylcholinesterase Inhibitors and Osteoporotic Fractures in Older Persons With Alzheimer's Disease.

Objective: To identify the association between the use of acetylcholinesterase inhibitors (AChEIs) and risk of osteoporotic fractures in older persons with Alzheimer's disease (AD).

Design, Setting, And Participants: A nested case-control study was conducted using the Korean National Health Insurance Service-National Elderly Cohort database. Patients with AD who were newly diagnosed with osteoporotic fractures were identified as cases.

Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease.

We investigated the presence of cerebral small vessel disease (SVD) in patients with nonarteritic anterior ischemic optic neuropathy (NAION) compared to control subjects without NAION to identify the association between NAION and cerebral SVD. We retrospectively reviewed the cases of 63 patients with NAION and 2749 control subjects without any neurologic and ocular diseases including NAION who underwent careful medical interviews, ophthalmic examinations, and magnetic resonance imaging (MRI) studies of the brain. We assessed and compared the degree of cerebral SVD on the MRIs.

Incremental economic burden associated with exudative age-related macular degeneration: a population-based study.

Background: The exudative age-related macular degeneration (AMD) causes considerable healthcare costs for patients and healthcare system, which are expected to grow as the population ages. The objective of this study was to assess the incremental economic burden of exudative AMD by comparing total healthcare costs between the exudative AMD group and non-AMD group to understand economic burden related to exudative AMD.

Methods: This retrospective cohort study used the National Health Insurance Service database including the entire Korean population.

Primary Open-angle Glaucoma and Increased Risk of Chronic Kidney Disease.

Precis: The association between primary open-angle glaucoma (POAG) and subsequent development of chronic kidney disease (CKD) was investigated using a nationwide, population-based, retrospective cohort in South Korea. POAG increases the risk of subsequent CKD development.

Purpose: The purpose of this study was to investigate the risk of subsequent CKD development in patients with POAG.

Risk of Nonarteritic Anterior Ischemic Optic Neuropathy After Cataract Surgery.

Purpose: To determine whether the development of nonarteritic anterior ischemic optic neuropathy (NAION) is increased after receiving cataract surgery in a large general population.

Design: Nationwide, population-based, retrospective cohort study.

Methods: Setting: A 12-year nationwide, population-based, retrospective cohort study including 1,025,340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database.

Five-year nationwide incidence of macular hole requiring surgery in Korea.

Background/aims: To estimate the incidence and demographics of macular hole (MH) requiring surgery in Korea.

Methods: Patients who underwent surgery for MH in Korea from 2011 to 2015 with the diagnostic code for MH and the surgical code for vitrectomy were retrospectively identified using the Korean national health claims database. The average incidence rate of MH during the 5-year study period was estimated by applying the direct method of standardisation using the 2015 census data as a reference population.

Risk of Stroke After Nonarteritic Anterior Ischemic Optic Neuropathy.

Purpose: To determine whether nonarteritic ischemic optic neuropathy (NAION) raises the risk of subsequent stroke in the general population.

Design: Population-based, retrospective cohort study.

Methods: Setting: Nationwide, population-based, retrospective cohort study.

Rehabilitation Therapy Utilization in Patients with Parkinson's Disease in Korea.

Objective: Although evidence and guidelines recommend appropriate rehabilitation from the beginning of diagnosis in patients with Parkinson's disease (PD), there is a lack of data addressing the utilization of rehabilitation therapies for these patients in practice. The aim of this study is to investigate the rate of rehabilitation therapy utilization over time in patients with PD using a nationwide cohort in Korea.

Methods: Patients were identified using the registration code for PD in the program for rare, intractable disease from the National Health Insurance Service-National Sample Cohort database, which consists of 979,390 Korean residents.

Obstructive sleep apnoea and increased risk of non-arteritic anterior ischaemic optic neuropathy.

Background/aims: To determine whether the development of non-arteritic anterior ischaemic optic neuropathy (NAION) is increased among patients newly diagnosed with obstructive sleep apnoea (OSA) in a large general population.

Methods: A 12-year nationwide, population-based, retrospective cohort study including 1 025 340 beneficiaries in the 2002-2013 Korean National Health Insurance Service database was performed. We identified 919 patients newly diagnosed with OSA aged ≥40 years and matched 9190 non-OSA controls using estimated propensity scores in reference to age, sex, demographics, comorbidities and co-medications.