Exploring the impact of Rubus ulmifolius leaf cream on wound healing in an in vivo model: VEGF, PDGF, and cytokine dynamics.

Rubus ulmifolius (RUI) Schott, commonly known as wild blackberry, is a perennial plant recognized for its traditional medicinal uses and diverse biological activities. This study aimed to evaluate the wound-healing efficacy of a topical cream formulated with RUI leaf extract. Thirty Wistar rats were used to assess wound contraction over 14 days.

Network pharmacology of olive stem extract, UPLC-HR-QTOF-MS profiling and antiviral activities aligned with UN sustainable development goals.

Olea europaea tree has long been a cornerstone of traditional medicine. Its different parts have been used as a remedy for viral accompanied diseases as asthma, sore throat, fever, and others. Despite its historical significance, olive stem's chemical diversity and pharmacological potential remain underexplored.

UHPLC-QTOF-MS/MS profiling, molecular networking, and molecular docking analysis of (Jacq.) Kunth. ex. Walp. stem ethanolic extract and its gastroprotective effect on gastritis in rats.

Metabolic profiling of the crude ethanolic extract of (Jacq.) Kunth. ex.

H. Wendl Leaf Metabolites Potentiate the Radiosensitivity of Hepatocellular Carcinoma Through Ki67 and PARP Inhibition.

Objectives: Hepatocellular carcinoma (HCC) represents the third-most prevalent cancer in humans worldwide. The current study's objective is to search for the potentiality of H. Wendl () leaf extract in a nanoemulsion (NE) form in enhancing radiotherapy against HCC induced in rats using diethylnitrosamine (DEN).

Gliricidia sepium (Jacq.) Kunth. ex. Walp. leaves-derived biogenic nanohydrogel accelerates diabetic wound healing in rats over 21 days.

This study focused on the potential of Gliricidia sepium (Jacq.) Kunth. ex.

Correction: Selim et al. Impact of Leaves on Gamma Irradiation-Induced Hepatotoxicity in Rats and Correlation with STING Pathway and Phenolic Composition. 2020, , 320.

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Biosynthesis and Characterization of -Derived Silver Nanoparticles: Antimicrobial Activity, Biofilm Inhibition, Antihemolytic Activity, and In Silico Studies.

Environmentally friendly biosynthesis of silver nanoparticles (AgNPs) from (L.) Webb & Berthel is reported for the first time. The synthesized AgNPs were characterized using UV-Vis, FTIR, TEM, Zeta potential, and XRD analysis, revealing high stability (-29.

Genus L.: a newly explored sustainable source of virulence inhibitors: a mini review.

Misuse of antibiotics led to the world wide spread of antimicrobial resistance threatening human lives. The notable resistance of bacterial cells to antibiotics and immune system is the difficulty associated with biofilm-linked illnesses. Natural products from plant origin with antibiofilm activity could provide more therapeutic activity with fewer adverse effects.

Eliciting Callus Cultures for the Production of Cytotoxic Polyphenolics from Roxb. Sweet.

Roxb. Sweet is a shrub known for its richness in secondary metabolites. A callus culture protocol was established to enhance its chemical profile.

Comparative metabolomics analysis of var. sarcodactylis Swingle and Linn. Fruits and leaves cultivated in Egypt in context to their antiviral effects.

A comprehensive study of fruits and leaves extracts of var. Swingle and L. family Rutaceae was accomplished to investigate their antiviral activity along with their zinc oxide nanoparticles formulation (ZnONPs) against the avian influenza H5N1 virus.

Green synthesis of zinc oxide nanoparticles using ethanolic extract of Gliricidia sepium (Jacq.) kunth. Ex. Walp., stem: Characterizations and their gastroprotective effect on ethanol-induced gastritis in rats.

The study presents a significant advancement in drug delivery and therapeutic efficacy through the successful synthesis of Gliricidia sepium(Jacq.) Kunth. ex.

Phytochemical Elucidation and Effect of (Roxb.) Sweet on Alleviation of Potassium Dichromate-Induced Pulmonary Damage in Rats.

(Roxb.) Sweet is one of the well-known traditionally-used Indian plants. This plant is rich in secondary metabolites like phenolic acids, flavonoids, alkaloids, glycosides, saponins, and carbohydrates.

LC-HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies.

In the current study, the actinomycetes associated with the red sea-derived soft coral Sarcophyton glaucum were investigated in terms of biological and chemical diversity. Four different media, M1, ISP2, Marine Agar (MA), and Actinomycete isolation agar (AIA) were used for the isolation of three strains of actinomycetes that were identified as Streptomyces sp. UR 25, Micromonospora sp.

Effect of Phenolics from on Alpha Glucosidase, Pancreatic Lipase, and Oxidative Stress; a Bio-Guided Approach.

Metabolic syndrome (MetS) is a global issue affecting over a billion people, raising the risk of diabetes, cardiovascular disorders, and other ailments. It is often characterized by hypertension, dyslipidemia and/or obesity, and hyperglycemia. Chemical investigation of (L.

Metabolomics analysis of var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle and Linn. fruits and leaves in perspective to their antimicrobial potential.

Antimicrobial potential of var. sarcodactylis (Siebold ex Hoola van Nooten) Swingle and L. fruits and leaves extracts CMF, CML, LAF and LAL, respectively were evaluated.

Pectin Nanoparticle-Loaded Soft Coral sp. Extract as Gel Enhances Chronic Wound Healing: , , and Studies.

This study shed light for the first time on the diabetic wound healing potential activity of natural marine soft coral polymeric nanoparticle gel using an excision wound model. A sp. methanol-methylene chloride extract loaded with pectin nanoparticles (LPNs) was created.

Promising Cytotoxic butenolides from the Soybean endophytic fungus Aspergillus terreus: a combined molecular docking and in-vitro studies.

Aim: This study aimed to use one strain many compounds approach (OSMAC) to investigate the cytotoxic potential of Aspergillus terreus associated with soybean versus several cancer cell lines, by means of in-silico and in vitro approaches.

Methods And Results: Fermentation of the isolated strain was done on five media. The derived extracts were investigated for their inhibitory activities against three human cancer cell lines; mammary gland breast cancer (MCF-7), colorectal adenocarcinoma (Caco-2), and hepatocellular carcinoma (HepG2) using MTT Assay.

Network pharmacology and molecular docking study for biological pathway detection of cytotoxicity of the yellow jasmine flowers.

Background: The yellow jasmine flower (Jasminum humile L.) is a fragrant plant belonging to the Oleaceae family with promising phytoconstituents and interesting medicinal uses. The purpose of this study was to characterize the plant metabolome to identify the potential bioactive agents with cytotoxic effects and the underlying mechanism of cytotoxic activity.

Metabolic profiling and biological activity of two species: and .

is a genus of family Arecaceae and widely grown in tropical areas. The phytochemical analysis of the leaves and fruits of two species, and were carried out using UPLC/MS and determination of the total phenolic and total flavonoid contents, in addition to the isolation and identification of five phenolic compounds and one fatty acid from fruits. The total phenolic compounds varied from 19.

Elicitation for activation of the actinomycete genome's cryptic secondary metabolite gene clusters.

This review summarizes the recent advances in the elicitation approaches used to activate the actinomycete genome's cryptic secondary metabolite gene clusters and shows the diversity of natural products obtained by various elicitation methods up to June 2022, such as co-cultivation of actinomycetes with actinomycetes, other non-actinomycete bacteria, fungi, cell-derived components, and/or algae. Chemical elicitation and molecular elicitation as transcription factor decoys, engineering regulatory genes, the promoter replacement strategy, global regulatory genes, and reporter-guided mutant selection were also reported. For researchers interested in this field, this review serves as a valuable resource for the latest studies and references.

Integration of LC/MS, NMR and Molecular Docking for Profiling of Bioactive Diterpenes from Euphorbia mauritanica L. with in Vitro Anti-SARS-CoV-2 Activity.

In spite of tremendous efforts exerted in the management of COVID-19, the absence of specific treatments and the prevalence of delayed and long-term complications termed post-COVID syndrome still urged all concerned researchers to develop a potent inhibitor of SARS-Cov-2. The hydromethanolic extracts of different parts of E. mauritanica were in vitro screened for anti-SARS-Cov-2 activity.

The Protective and Therapeutic Anti-Alzheimer Potential of L. cv. Picual: An In Silico and In Vivo Study.

LC-HRESIMS metabolomic profiling of L. cv. Picual (OEP) (Saudi Arabian olive cultivar, F.