Beyond the lung: Distinct recurrence patterns of mucinous and non-mucinous lung adenocarcinoma after surgery.

Objectives: This study aimed to investigate differences in recurrence patterns between invasive mucinous adenocarcinoma and non-mucinous adenocarcinoma following surgical resection in patients with lung cancer without nodal or systemic metastasis.

Methods: We retrospectively analysed the patients' data who underwent curative surgery for adenocarcinoma between 2011 and 2021. To balance clinical characteristics, 2:1 propensity score matching was performed.

Wedge resection versus segmentectomy in early-stage lung cancer considering resection margin and lymph node evaluation: A retrospective study.

Objectives: The prognostic differences between wedge resection and segmentectomy in early-stage lung cancer remain controversial. This study aimed to compare the recurrence-free survival (RFS) between the two procedures, focusing on the impact of resection margin status and adequacy of lymph node (LN) evaluation.

Methods: Patients who underwent sublobar resection for clinical stage IA1-IA2 primary lung adenocarcinoma between 2011 and 2021 were retrospectively reviewed.

Central Tumor Location in Resected Lung Adenocarcinoma: Association with Recurrence and Survival Outcomes.

Prognostic implications of lung cancer location remain uncertain, in part relating to heterogeneous definitions for central tumor location. To assess associations of central tumor location, determined using an automated lung segmentation algorithm, with recurrence and survival outcomes in patients with resected lung adenocarcinoma. This retrospective study included patients who underwent lobectomy or pneumonectomy for invasive lung adenocarcinoma between July 2010 and December 2019.

Prognostic impact of extracapsular extension of lymph nodes in resected lung cancer: analysis by new N subcategories and histologic types.

Objectives: Despite being an R1 descriptor, the effects of extracapsular extension (ECE) on survival are inconsistent and remains invalidated under N2 subcategorization (pN2a and pN2b). This study aimed to validate the survival effect of ECE across N subcategories and histologic types.

Materials And Methods: Patients who underwent lobectomy or pneumonectomy for NSCLC between 2010 and 2022, with proven pN-positive status and Union for International Cancer Control R0 designation, were retrospectively included.

Prognostic Variability in Non-Small Cell Lung Cancer with Pathologic Separate Nodules in the Same Lobe at CT.

Background Patients with stage T3 non-small cell lung cancer (NSCLC) with separate nodules (SNs) have been reported to have better outcomes than those with T3 tumors with other descriptors, but heterogeneity may exist depending on nodule characteristics. Purpose To identify prognostic factors based on the imaging features of SNs among patients with pathologically confirmed SNs in the same lobe. Materials and Methods This retrospective study included patients with pT2b-pT3 NSCLC who underwent lobectomy or pneumonectomy between January 2010 and December 2021.

Revisiting margin adequacy in sublobar resection for pure ground-glass opacity adenocarcinomas.

Background: Pure ground-glass opacity (GGO) lesions have a favorable prognosis and are primarily treated with sublobar resection. Current guidelines uniformly define sufficient margins as greater than 2 cm or the size of the lesion, regardless of the lesion's characteristics. This study evaluates the prognostic impact of insufficient margins in sublobar resection for pure GGO adenocarcinomas.

Comparative validation of clinical staging based on solid component versus total tumor size in resected lung adenocarcinoma.

Objectives: To compare clinical staging based on total tumor size with that of solid component size using the same criteria.

Materials And Methods: Patients who underwent curative resection for clinical stage IA1-IB adenocarcinoma between 2011 and 2021 were retrospectively included. Patients were re-staged according to the criteria of the current TNM staging using total tumor size (cStage) and solid component size (cStage).

Validation of the 9th Tumor, Node, and Metastasis Staging System for Patients with Surgically Resected Non-Small Cell Lung Cancer.

Introduction: The ninth edition of the tumor, node, and metastasis (TNM) classification system was recently published by the International Association for the Study of Lung Cancer staging project. This study aimed to validate the ninth edition of the TNM staging system, and compare its discrimination power with that of the eighth edition.

Methods: Patients who had undergone complete resection with systematic lymph node dissection for non-small cell lung cancer (NSCLC) were included in this retrospective analysis.

Analysis of lymph node metastasis based on consolidation tumor ratio and maximum standardized uptake value in clinical stage IA non-small cell lung cancer.

Background: Sublobar resection has been established as an acceptable treatment for early-stage non-small cell lung cancer (NSCLC). As a result, preoperative prediction of lymph node (LN) metastasis is becoming an important factor in determining surgical strategy. This study aimed to investigate the predictive accuracy of the consolidation tumor ratio (CTR) and the maximum standardized uptake value (maxSUV) of the primary tumor for LN metastasis in patients with clinical stage IA NSCLC.

Validation of changes in stage by the new N category in the 9th edition of lung cancer staging for resected non-small cell lung cancer.

Introduction: The reclassification following N2 subcategorization (N2a vs. N2b) in the 9th edition of lung cancer staging has not yet been externally validated. This study aimed to evaluate and compare the survival outcomes of reclassified stages in patients with resected non-small cell lung cancer.

Prevalence and Risk Factors for Pathologic N2 Disease in Resected Lung Cancers Assessed as N0 or N1 Disease on Preoperative Imaging.

For certain patients with lung cancer, guidelines recommend endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) as the primary method to evaluate for metastatic mediastinal lymph nodes defining pN2 disease. EBUS-TBNA has associated costs and complications and possibly limited availability. The purpose of the present study was to investigate the prevalence of and risk factors for pN2 disease in patients undergoing resection of lung cancer who were assessed as having radiologic N0 or N1 disease.

Improved Results Over Time With Bridge-to-Lung Transplantation: A 10-Year Experience of a Single High-Volume Center.

When donor scarcity limits timely lung transplantation (LTx), extracorporeal membrane oxygenation (ECMO) as a bridge to transplantation (BTT) can prolong survival and delay deconditioning until the donor lungs become available. We reviewed 10-year BTT experiences of a single high-volume center, where 99 (59%) were on ECMO BTT among 169 eligible adult LTx cases. Both 28-day and 2-year survivals did not differ between BTT and non-BTT.

Prognostic Implications of the Volume Doubling Time of the Solid Component in Lung Adenocarcinomas Manifesting as Part-Solid Lesions on Chest CT.

In lung adenocarcinomas manifesting as part-solid lesions, evidence supports greater prognostic importance for the volume of the solid component than that of the whole nodule. However, assessments of lesion growth rates have historically focused on the volume doubling time (VDT) of the whole lesion. The purpose of the study was to compare the prognostic utility of the VDT of the solid component versus the VDT of the whole lesion for resected lung adenocarcinomas manifesting as part-solid lesions on chest CT.

Stereotactic ablative radiotherapy for pulmonary metastasis from sarcoma: a retrospective comparison with metastasectomy.

Recent studies report excellent local control (LC) and favorable toxicities of stereotactic ablative radiotherapy (SABR) for pulmonary metastasis (PM) from sarcoma. This study compared the LC and survival of SABR and metastasectomy for sarcoma PM. We analyzed the LC rates of 54 PMs treated with SABR between 2008 and 2022.

Predicting Recurrence after Sublobar Resection in Patients with Lung Adenocarcinoma Using Preoperative Chest CT Scans.

Background Sublobar resection for lung cancer is usually guided by cutoff values for consolidation size (maximal diameter of the solid tumor component) and consolidation-to-tumor ratio (CTR). The effects of these factors as continuous variables and the reason for established cutoffs are, to the knowledge of the authors, unexplored. Purpose To quantitatively assess the predictive value of CTR and consolidation size for cancer recurrence risk after sublobar resection in clinical stage IA lung adenocarcinoma.

Comparison of Metastasectomy and Stereotactic Body Radiation Therapy for Pulmonary Oligometastasis From Hepatocellular Carcinoma: A Propensity Score-Weighted Analysis.

Purpose: Although there is a growing role for local therapy in patients with hepatocellular carcinoma (HCC) and pulmonary oligometastasis, it remains unclear whether metastatectomy or stereotactic body radiation therapy (SBRT) is the more effective treatment for these patients. We aimed to compare the oncologic outcomes of metastasectomy and SBRT for HCC with pulmonary oligometastasis.

Methods And Materials: We retrospectively analyzed 209 patients with HCC with 322 metastatic lung lesions who underwent either metastasectomy (150 patients with 241 lesions) or SBRT (59 patients with 81 lesions) between January 2008 and December 2018.

The prognostic value of lymphovascular invasion for stage I lung adenocarcinoma based on the presence of ground-glass opacity.

Objectives: There is still a debate regarding the prognostic implication of lymphovascular invasion (LVI) in stage I lung adenocarcinoma. Ground-glass opacity (GGO) on CT is known to correlate with a less invasive or lepidic component in adenocarcinoma, which may influence the strength of prognostic factors. This study aimed to explore the prognostic value of LVI in stage I lung adenocarcinoma based on the presence of GGO.

Surgical prognosis of lung invasive mucinous and non-mucinous adenocarcinoma: propensity score matched analysis.

Objectives: Invasive mucinous adenocarcinoma exhibits distinct prognostic outcomes compared to non-mucinous adenocarcinoma (ADC). This study investigated and compared the clinical outcomes and prognostic factors of invasive mucinous and non-mucinous ADC patients.

Methods: This retrospective study included patients who underwent curative surgery for ADC between 2011 and 2021.

Risk prediction of multiple-station N2 metastasis in patients with upfront surgery for clinical single-station N2 non-small cell lung cancer.

To investigate long-term outcomes and develop a risk model for pathological multi-station N2 (pN2b) in patients who underwent upfront surgery for clinical single-station N2 (cN2a) non-small cell lung cancer (NSCLC). From 2006 to 2018, 547 patients who had upfront surgery for suspected cN2a NSCLC underwent analysis. A risk model for predicting pN2b metastasis was developed using preoperative clinical variables via multivariable logistic analysis.

Prognostic Implications of Selective Dissection of Left Lower Paratracheal Lymph Nodes in Patients with Left-Sided Non-Small Cell Lung Cancer.

Background: This study aimed to examine the clinical implications of selective station 4L lymph node dissection (S4L-LND) on survival in non-small cell lung cancer (NSCLC) and to evaluate its potential advantages.

Methods: We enrolled patients with primary left-sided NSCLC who underwent upfront video-assisted thoracoscopic surgery with R0 resection including lobectomy and segmentectomy, with or without S4L-LND, at our institution between January 2007 and December 2021. Following 1:1 propensity score matching (PSM), we compared overall survival (OS) and recurrence-free survival (RFS) between patients with and without S4L-LND.

Recurrence Dynamics of Pathological N2 Non-Small Cell Lung Cancer Based on IASLC Residual Tumor Descriptor.

Purpose: This study investigated the recurrence patterns and timing in patients with pathologic N2 (pN2) non-small cell lung cancer (NSCLC) according to the residual tumor (R) descriptor proposed by the International Association for the Study of Lung Cancer (IASLC).

Materials And Methods: From 2004 to 2021, patients with pN2 NSCLC who underwent anatomical resection were analyzed according to the IASLC R criteria using medical records from a single center. Survival analysis was performed using Cox proportional hazards models.

Expansion of tumor-infiltrating lymphocytes in non-small cell lung cancer: Clinical potential and efficacy in EGFR mutation subsets.

Our study aimed to expand tumor-infiltrating lymphocytes (TILs) from primary non-small cell lung cancers (NSCLCs) and evaluate their reactivity against tumor cells. We expanded TILs from 103 primary NSCLCs using histopathological analysis, flow cytometry, IFN-γ release assays, cell-mediated cytotoxicity assays, and in vivo efficacy tests. TIL expansion was observed in all cases, regardless of EGFR mutation status.

Adjuvant surgical resection for nontuberculous mycobacterial pulmonary disease: Effectiveness and complications.

Background: Standard antibiotic treatment for nontuberculous mycobacteria pulmonary disease (NTMPD) has unsatisfactory success rates. Pulmonary resection is considered adjunctive therapy for patients with refractory disease or severe complications, but surgical indications and extent of resection remain unclear. We present surgical treatment outcomes for NTMPD and analyzes risk factors for unfavorable outcomes.