Contributions of inherited mtDNA to longevity: evidence from extended pedigrees with 176 million kinship pairs.

Background: Mitochondria are bacteria-like organelles with their own DNA (mtDNA) that exist in the cellular cytoplasm of almost every cell in the human body. Because mitochondria are critical for sustaining life, it follows that inherited mtDNA could be a key aetiologic element underlying longevity. Unfortunately, biometric approaches able to quantify heritable contributions of mtDNA have not been available.

Understanding desistance from aggression: A joint interpretation of person-centered and variable-centered approaches.

When leveraged together, variable-centered and person-centered statistical methods have the potential to illuminate the factors predicting mental health recovery. However, because extant studies have largely relied on only one of these methods, we do not yet understand why some youth demonstrate recovery while others experience chronic symptoms. This omission limits our understanding of trajectories of physical aggression (AGG) in particular, which are frequently characterized by desistance.

Detecting mtDNA Effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias.

Mitochondrial DNA (mtDNA) plays a crucial role in numerous cellular processes, yet its impact on human complex behavior remains underexplored. The current paper proposes a novel covariance structure model with seven parameters to specifically isolate and quantify mtDNA effects on human complex traits. This approach uses extended pedigrees to obtain estimates of mtDNA variance while controlling for other genetic and environmental influences.

Detecting mtDNA effects with an Extended Pedigree Model: An Analysis of Statistical Power and Estimation Bias.

Mitochondrial DNA (mtDNA) plays a crucial role in numerous cellular processes, yet its impact on human behavior remains underexplored. The current paper proposes a novel covariance structure model with seven parameters to specifically isolate and quantify mtDNA effects on human behavior. This approach uses extended pedigrees to obtain estimates of mtDNA variance while controlling for other genetic and environmental influences.

A spatially explicit assessment of factors shaping attitudes toward African elephant conservation.

Conservation plans that explicitly account for the social landscape where people and wildlife co-occur can yield more effective and equitable conservation practices and outcomes. Yet, social data remain underutilized, often because social data are treated as aspatial or are analyzed with approaches that do not quantify uncertainty or address bias in self-reported data. We conducted a survey (questionnaires) of 177 households in a multiuse landscape in the Kenya-Tanzania borderlands.

Evaluating density-weighted connectivity of black bears (Ursus americanus) in Glacier National Park with spatial capture-recapture models.

Background: Improved understanding of wildlife population connectivity among protected area networks can support effective planning for the persistence of wildlife populations in the face of land use and climate change. Common approaches to estimating connectivity often rely on small samples of individuals without considering the spatial structure of populations, leading to limited understanding of how individual movement links to demography and population connectivity. Recently developed spatial capture-recapture (SCR) models provide a framework to formally connect inference about individual movement, connectivity, and population density, but few studies have applied this approach to empirical data to support connectivity planning.

Identifying the 'active ingredients' of socioeconomic disadvantage for youth outcomes in middle childhood.

Background: Youth experiencing socioeconomic deprivation may be exposed to disadvantage in multiple contexts (e.g., neighborhood, family, and school).

The development of youth antisocial behavior across time and context: A systematic review and integration of person-centered and variable-centered research.

Background: Trajectories of youth antisocial behavior (ASB) are characterized by continuity and change. Although numerous longitudinal studies have examined ASB, findings from person-centered and variable-centered research have not yet been integrated. The present paper integrates findings across statistical methods for a more comprehensive understanding of the development of ASB.

Disadvantage and disordered eating in boys: Examining phenotypic and genotype × environment associations across development.

Socioeconomic disadvantage may be a significant risk factor for disordered eating, particularly for individuals with underlying genetic risk. However, little to nothing is known about the impact of disadvantage on disordered eating in boys during the critical developmental risk period. Crucially, risk models developed for girls may not necessarily apply to boys, as boys show different developmental patterns of disordered eating risk (i.

Precision and bias of spatial capture-recapture estimates: A multi-site, multi-year Utah black bear case study.

Spatial capture-recapture (SCR) models are powerful analytical tools that have become the standard for estimating abundance and density of wild animal populations. When sampling populations to implement SCR, the number of unique individuals detected, total recaptures, and unique spatial relocations can be highly variable. These sample sizes influence the precision and accuracy of model parameter estimates.

Understanding the effects of neighborhood disadvantage on youth psychopathology.

Background: In 1942, Shaw and McKay reported that disadvantaged neighborhoods predict youth psychopathology (Shaw & McKay, ). In the decades since, dozens of papers have confirmed and extended these early results, convincingly demonstrating that disadvantaged neighborhood contexts predict elevated rates of both internalizing and externalizing disorders across childhood and adolescence. It is unclear, however, neighborhood disadvantage increases psychopathology.

Context matters: Neighborhood disadvantage is associated with increased disordered eating and earlier activation of genetic influences in girls.

Emerging evidence suggests socioeconomic disadvantage may increase risk for eating disorders (EDs). However, there are very few studies on the association between disadvantage and EDs, and all have focused on individual-level risk factors (e.g.

Understanding the Effects of the COVID-19 Pandemic on Youth Psychopathology: Genotype-Environment Interplay.

Background: Adversity has consistently been found to predict poor mental health outcomes in youth. Perhaps the most omnipresent form of adversity in the past several decades has been the coronavirus pandemic of 2020, a global health crisis linked to elevated rates of numerous forms of youth psychopathology. The ongoing nature of the pandemic renders it critical to identify the mechanisms underlying its effects on mental health.

A proteomic analysis of the effect of ocean acidification on the haemocyte proteome of the South African abalone Haliotis midae.

As a result of increasing CO emissions and the prevalence of global climate change, ocean acidification (OA) is becoming more pervasive, affecting many trophic levels, particularly those that rely on succinctly balanced ocean chemistry. This ultimately threatens community structures, as well as the future sustainability of the fishing/aquaculture industry. Understanding the molecular stress response of key organisms will aid in predicting their future survivability under changing environmental conditions.

Continuity and Change in the Genetic and Environmental Etiology of Youth Antisocial Behavior.

Trajectories of youth antisocial behavior (ASB) are characterized by both continuity and change. Twin studies have further indicated that genetic factors underlie continuity, while environmental exposures unique to each child in a given family underlie change. However, most behavioral genetic studies have examined continuity and change during relatively brief windows of development (e.

The use of pedometers in stroke survivors: are they feasible and how well do they detect steps?

Objectives: To determine (1) the feasibility of pedometers for stroke patients and (2) the level of agreement between pedometers and actual step count.

Design: Observational agreement study.

Setting: Six stroke units.