Publications by authors named "Sara A Stickley"
Gene-by-environment interactions modulate the infant gut microbiota in asthma and atopy.
J Allergy Clin Immunol
August 2025
Background: Gut microbiota has been associated with health and susceptibility to childhood diseases, including asthma and allergies. However, the genomic factors contributing to interindividual variations in gut microbiota remain poorly understood.
Objective: We sought to integrate host genomics with early-life exposures to investigate main and interaction effects on gut microbiota during the first year of life.
Article Synopsis
- The study investigates the impact of the human milk microbiota (HMM) on the long-term health of children, particularly focusing on asthma and allergic conditions like atopy.
- Researchers followed 885 mothers and their children from birth to age 5, linking HMM composition to the mothers' genetics and children's health outcomes.
- Findings suggest that certain bacterial communities in human milk, especially decreased diversity and increased Lawsonella, are correlated with higher rates of childhood atopy and asthma, highlighting the genetic influence on HMM composition.
Article Synopsis
- This study explores the relationship between maternal genetics, human milk oligosaccharides (HMOs), and respiratory health in infants fed human milk.
- Researchers quantified 19 HMOs from 980 mothers and identified genetic markers linked to HMOs on several chromosomes, including notable findings on chromosomes 19 and 3.
- The study suggests that certain HMOs may help reduce the risk of respiratory issues, like recurrent wheezing, in preschoolers, depending on their genetic predispositions.