Publications by authors named "Amanda M Zacharias"
Biological rhythms control gene expression, but effects on central nervous system (CNS) cells and structures remain poorly defined. While circadian (24-hour) rhythms are most studied, many genes have periods of greater and less than 24-hours; these fluctuations can be both site- and cell-specific. Identifying patterns of gene rhythmicity across the CNS is necessary for both the study of chronobiology and to make sense of data obtained in the laboratory.
View Article and Find Full Text PDFGene-by-environment interactions modulate the infant gut microbiota in asthma and atopy.
J Allergy Clin Immunol
August 2025
Background: Gut microbiota has been associated with health and susceptibility to childhood diseases, including asthma and allergies. However, the genomic factors contributing to interindividual variations in gut microbiota remain poorly understood.
Objective: We sought to integrate host genomics with early-life exposures to investigate main and interaction effects on gut microbiota during the first year of life.
Advanced metastatic colorectal cancer (CRC) with deficient DNA mismatch repair (MMR-d), or immune-hot CRCs, show significantly improved clinical outcomes compared to MMR-proficient (MMR-p), or immune-cold CRCs. While the prior represents about 5% of all CRCs, the latter represent 95% and are characterized by low immunogenicity. This study investigates bis-diethyldithiocarbamate (CuET), a novel anticancer compound, and its impact on the colorectal cancer tumor microenvironment (TME).
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- The study investigates the impact of the human milk microbiota (HMM) on the long-term health of children, particularly focusing on asthma and allergic conditions like atopy.
- Researchers followed 885 mothers and their children from birth to age 5, linking HMM composition to the mothers' genetics and children's health outcomes.
- Findings suggest that certain bacterial communities in human milk, especially decreased diversity and increased Lawsonella, are correlated with higher rates of childhood atopy and asthma, highlighting the genetic influence on HMM composition.
Introduction: One in five Canadians lives with chronic pain. Evidence shows that some individuals experience pain that fluctuates in intensity following a circadian (24-hour) rhythm. Endogenous molecular rhythms regulate the function of physiological processes that govern pain mechanisms.
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