Publications by authors named "Santhoshkumar Muthu"
Hypogonadism in males has been identified as one of the risk factors for type 2 diabetes mellitus (T2DM). Testosterone treatment is beneficial for T2DM in both preclinical and clinical studies. Testosterone enhances insulin secretion and maintains β-cell health by activating androgen receptors (AR).
View Article and Find Full Text PDFGene network analysis combined with preclinical studies to identify and elucidate the mechanism of action of novel irreversible Keap1 inhibitor for Parkinson's disease.
Monisha Arumugam
,
Ranjith Sanjeeve Pachamuthu
,
Emdormi Rymbai
,
Aditya Prakash Jha
,
Kalirajan Rajagopal
,
Santhoshkumar Muthu
Mol Divers
June 2025
Article Synopsis
- The study focuses on identifying new covalent inhibitors of Keap1 that can activate Nrf2 by modifying key cysteine residues (C151, C273, C288) to enhance neuroprotection.
- Researchers used various computational and in-vitro methods, concluding that plumbagin formed stable covalent bonds with the cysteine residues and demonstrated neuroprotective properties in cell studies.
- Plumbagin not only improved cognitive function and reduced symptoms in rat models of Parkinson's disease but also activated Nrf2, suggesting it has potential antioxidant and anti-inflammatory effects.
Syringaresinol as a novel androgen receptor antagonist against wild and mutant androgen receptors for the treatment of castration-resistant prostate cancer: molecular docking, and molecular dynamics study.
Divakar Selvaraj
,
Santhoshkumar Muthu
,
Satvik Kotha
,
Ramachandra Setty Siddamsetty
,
Sasikumar Andavar
J Biomol Struct Dyn
February 2021
Phytoestrogens are dietary estrogens having similar structure as of estrogen. Some of these phytoestrogens are androgen receptor (AR) antagonists and exhibit preventive role in the prostate cancer. However, in androgen-independent prostate cancer (AIPC) the ARs were mutated (T877A, W741L, F876L, etc.
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