Publications by authors named "Aditya Prakash Jha"
Article Synopsis
- The study focuses on identifying new covalent inhibitors of Keap1 that can activate Nrf2 by modifying key cysteine residues (C151, C273, C288) to enhance neuroprotection.
- Researchers used various computational and in-vitro methods, concluding that plumbagin formed stable covalent bonds with the cysteine residues and demonstrated neuroprotective properties in cell studies.
- Plumbagin not only improved cognitive function and reduced symptoms in rat models of Parkinson's disease but also activated Nrf2, suggesting it has potential antioxidant and anti-inflammatory effects.
