Publications by authors named "Saeed Behboodifar"
Article Synopsis
- Scientists made a special type of medicine called RS liposomal doxorubicin using a compound called DDA that reacts to certain chemicals in tumors.
- They created small particles (liposomes) that can carry this medicine and found that they work well in lab tests with mice that have cancer, helping them live longer.
- The study showed that adding a specific ingredient (HSPC) to the liposomes made them stronger and better at releasing medicine when needed, especially in the environment of tumor cells.
Due to its involvement in skin maintenance and repair, topical administration of recombinant human growth hormone (rhGH) is an interesting strategy for therapeutic purposes. We have formulated and characterized a topical rhGH-loaded liposomal formulation (rhGH-Lip) and evaluated its safety, biological activity, and preventive role against UVB-induced skin damage. The rhGH-Lip had an average size and zeta potential of 63 nm and -33 mV, respectively, with 70 % encapsulation efficiency.
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- mRNA-lipid nanoparticle (mRNA-LNP) vaccines, like Iribovax® (SNEG2c), have shown strong efficacy and quick manufacturing during the COVID-19 pandemic, effectively stimulating immune responses in various animal models.
- SNEG2c vaccination led to high levels of SARS-CoV-2 spike-specific antibodies and a significant T-cell response, surpassing the antibody levels found in COVID-19 survivors.
- Further studies confirmed that SNEG2c is safe and stable, completely clearing the virus from vaccinated macaques and protecting them from serious lung damage, supporting its future human trials.