Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy.

Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by ubiquitous deficiency in the SMN protein. The identification of disease modifiers is key to understanding pathogenic mechanisms and broadening the range of targets for developing SMA therapies that complement SMN upregulation. Here, we report a cell-based screen that identified inhibitors of p38 mitogen-activated protein kinase (p38 MAPK) as suppressors of proliferation defects induced by SMN deficiency in mouse fibroblasts.

Undifferentiated Carcinoma With Osteoclast-like Giant Cells of the Pancreaticobiliary Tract: A Single Tertiary-Care-Oncology Center Case Series.

Undifferentiated carcinomas with osteoclast-like giant cells of the pancreaticobiliary tract (UCOGCs) are rare but distinctive tumors with limited literature. To study the clinicopathologic characteristics of UCOGCs including morphology, immunohistochemistry (IHC), management, and survival outcomes. Assessment of 12 patients of UCOGC found over 10 years from a tertiary care oncology center database.

Synthesis of BODIPY-Linked N-Heterocyclic Carbene Metal Complexes for Cancer Chemotheranostics and Catalysis Applications.

Fluorescent N-heterocyclic carbene (NHC) metal complexes are useful for various chemical and biological applications. In this study, we developed a simple strategy to synthesize BODIPY-linked NHC metal complexes involving Ag, Cu, Ni, and Pd. The synthesis began with the preparation of BODIPY-imidazolium salt as a precursor ligand.

Spirometry findings of chronic lung disease in high-altitude residents of Ladakh (>11,000 feet above sea level).

Ladakh is a hilly Himalayan dry desert, situated at an altitude of >11,000 feet. Studies have demonstrated that the spirometric values of high-altitude residents are significantly higher than those of low landers. This is a retrospective observational study that analyzes the spirometry pattern in chronic lung diseases among people from Ladakh.

Comparative Analysis of Bone vs. Tooth Anchored Maxillary Protraction in Cleft Lip and Palate Patients-A Systematic Review and Meta-Analysis.

Management of class III malocclusion in patients with cleft is geared toward improving the maxillary position with maxillary protraction therapy with or without bone anchorage. This study aims at evaluating the effects of bone-anchored maxillary protraction (BAMP) and tooth-anchored maxillary protraction (TAMP) appliances in patients with cleft lip and palate (CLP). A search of PubMed MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, ProQuest Dissertations and Theses Global, and ClinicalTrials.