Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength.

Aging is associated with a progressive decline in tissue function and regenerative capacity, partly due to genomic instability, one of the hallmarks of aging. Genomic instability encompasses DNA damage and the accumulation of somatic mutations in post-zygotic cells, yet the specific impact of these mutations on age-related tissue dysfunction remains poorly understood. To address this, we developed a mouse model in which genomic instability was induced specifically in muscle progenitor cells through targeted deletion of the Msh2 (ref.

Understanding how patient education affects the process of treatment decision-making: Cultural model change in kidney disease therapy.

Objective: Chronic kidney disease affects 1 in 7 people in the US, and 1 in 6 US Veterans. Treatment for kidney failure includes home dialysis, which, despite its benefits, is infrequently used. A major barrier to using home dialysis is receiving adequate education about it.

Clinical Profile and Neurological Outcomes of Pediatric Patients Supported on Venoarterial Extracorporeal Mechanical Oxygenation in a Cardiorespiratory Pediatric Intensive Care Unit: A Single-Center Study.

Extracorporeal membrane oxygenation (ECMO) has become a standard therapy in extremely sick patients for various indications. This rising use of ECMO warrants careful consideration of its neurological effects. Our single-center retrospective study, conducted between January 2016 and December 2022, on children ≤16 years, aimed to identify clinical and biochemical parameters associated with adverse neurological complications (ANC) on venoarterial ECMO (VA-ECMO), and its impact on their morbidity and mortality.

Decision Readiness and Determinants of KRT among Veterans with Advanced CKD.

Key Points: Most prevalent patients with advanced CKD are unable to select any KRT modality for themselves, highlighting concerns with advanced CKD clinical care. Prior receipt of KRT-directed education is associated with greater KRT decision readiness and home dialysis selection. Objective disease knowledge is among the strongest and most modifiable predictors of the KRT decision readiness, its quality, and home dialysis choice.

VALID AND INFORMED CONSENT IN ORTHOPAEDIC SURGERY: A MULTICENTRE, REGIONAL SERVICE EVALUATION OF CURRENT UK PRACTICE.

Background: In recent years, there has been increasing focus upon tailoring the consent process to reflect patients' individual needs and concerns. Meanwhile, clinical litigation costs for 'failure to warn' as part of 'informed consent' remain staggeringly high. We aimed to investigate the validity of the patient consent process in elective lower limb arthroplasty surgery regionally, with a view to ascertaining how it could be improved.