The Cost-Effectiveness of Tenofovir Alafenamide for Chronic Hepatitis B Virus in Taiwan.

Unlabelled: Chronic hepatitis B (CHB) is a lifelong disease requiring long-term or indefinite therapy, resulting in substantial economic burden. Thus, careful consideration must be used in the selection of therapies. This analysis assessed the cost-effectiveness of tenofovir alafenamide (TAF) compared with tenofovir disoproxil fumarate (TDF) and entecavir (ETV) from the perspective of the Taiwan National Health Insurance Administration Healthcare payer for the management of CHB over a lifetime horizon.

Development of the natural history component of an early economic model for primary sclerosing cholangitis.

Background: Primary sclerosing cholangitis (PSC) is a rare, chronic cholestatic disease that can progress to cirrhosis and liver failure. The natural history of PSC is variable as liver enzymes and liver symptoms fluctuate over time. Several drugs for PSC are under investigation, but there are currently no economic models to evaluate the cost-effectiveness and value of new treatments.

Presence of microplastics during high rainfall events in the Cauvery River (South India): Ecological risk and cultural practices.

Rivers directly support the development of a region/country; however, globally, these aquatic regions are impacted by recent human activity. During a rainfall event, we monitored the baseline information on the spatial variability of microplastics (MPs) in the Cauvery River in South India. Forty surface water samples from two selected sites were collected between 27 September and 16 October 2022 during the commencement of monsoon which indicates 69 and 43 pieces L of MPs, respectively.