Acute nicotinamide riboside supplementation increases human cerebral NAD levels in vivo.

Purpose: The purpose of this study was to determine the effect of acute nicotinamide riboside (NR) supplementation on cerebral nicotinamide adenine dinucleotide (NAD) levels in the human brain in vivo by means of downfield proton MRS (DF H MRS).

Methods: DF H MRS was performed on 10 healthy volunteers in a 7.0 T MRI scanner with spectrally selective excitation and spatially selective localization to determine cerebral NAD levels on two back-to-back days: once after an overnight fast (baseline) and once 4 h after oral ingestion of nicotinamide riboside (900 mg).

Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy.

Creatine chemical exchange saturation transfer (CrCEST) MRI is an emerging high resolution and noninvasive method for measuring muscle specific oxidative phosphorylation (OXPHOS). However, CrCEST measurements are sensitive to changes in muscle pH, which might confound the measurement and interpretation of creatine recovery time (τ). Even with the same prescribed exercise stimulus, the extent of acidification and hence its impact on τ is expected to vary between individuals.

In vivo enhancement of calf MRI at 7 T via optimized flexible metasurfaces.

Purpose: Ultrahigh field (≥7 T) MRI is at the cutting edge of medical imaging, enabling enhanced spatial and spectral resolution as well as enhanced susceptibility contrast. However, transmit ( ) field inhomogeneity due to standing wave effects caused by the shortened RF wavelengths at 7 T is still a challenge to overcome. Novel hardware methods such as dielectric pads have been shown to improve the field inhomogeneity but are currently limited in their corrective effect by the range of high-permittivity materials available and have a fixed shelf life.

In vivo assessment of β-hydroxybutyrate metabolism in mouse brain using deuterium ( H) MRS.

Purpose: To monitor the metabolic turnover of β-hydroxybutyrate (BHB) oxidation using H-MRS in conjunction with intravenous administration of H labeled BHB.

Methods: Nine-month-old mice were infused with [3,4,4,4]- H -BHB (d -BHB; 3.11 g/kg) through the tail vein using a bolus variable infusion rate for a period of 90 min.

Designing the careful and kind clinic: an evidence-based approach.

Background: There is evidence that creating a 'healthy workplace' can be of profound importance for clinicians, team members and patients. Yet there have been few papers that have proposed mechanisms to take decades of research and translate this into a practical list of options for leaders and managers to take into account when structuring a clinic based on care and kindness to achieve optimal health.

Evidence: We bring together 20 years of scholarship linking care of the caregivers with outcomes for caregivers and patients.

An in-house learning laboratory for patient-centered innovation.

Profound economic and social forces are challenging healthcare organizations to deliver higher quality care that is more patient-centered and evidence-based. We describe a novel way in which organizations can respond to the challenge of patient-centered, evidence-based innovation--an in-house learning laboratory for healthcare delivery services and processes. Mayo Clinic's SPARC Innovation Program, initiated in 2002 and fully operational in 2005, facilitates the generation of new ideas, tests prototypes, and disseminates the knowledge required for systemic, repeatable organizational innovation.

The application of design principles to innovate clinical care delivery.

Clinical research centers that support hypothesis-driven investigation have long been a feature of academic medical centers but facilities in which clinical care delivery can be systematically assessed and evaluated have heretofore been nonexistent. The Institute of Medicine report "Crossing the Quality Chasm" identified six core attributes of an ideal care delivery system that in turn relied heavily on system redesign. Although manufacturing and service industries have leveraged modern design principles in new product development, healthcare has lagged behind.