Cassane diterpenoids with hepatic gluconeogenesis inhibitory activity from the seeds of Caesalpinia decapetala (Roth) Alston.

A chemical investigation of the seeds of Caesalpinia decapetala (Roth) Alston led to the isolation of fifteen cassane diterpenoids, including ten previously undescribed compounds (1-10) and five known analogues (11-15). The structures of 1-10 were determined using H, C, and 2D NMR, HRESIMS, and IR data. Their absolute configurations were confirmed by comparing experimental electronic circular dichroism data with calculated values, coupled with single-crystal X-ray diffraction analysis.

Clerodane Diterpenoids and Ecdysteroids From the Fruits of Tinospora sagittata (Oliv.) Gagnep.

A new clerodane-type diterpenoid, tinosaginoside A (1), and two new ecdysteroids, tinosagisterones A and B (8 and 9), were isolated from the fruits of Tinospora sagittata (Oliv.) Gagnep., as well as and nine previously reported compounds (2-7 and 10-12).

Nicotabacins A-P, New Cembrane-Type Diterpenes Isolated from L. and Their Antifungal Activities.

Sixteen previously undescribed cembrane-type diterpenoids, named nicotabacins A-P (-), were isolated from L., together with 12 known analogs (-). The structures of - were determined by extensive spectral analysis, single-crystal X-ray diffraction analysis, and ECD calculations.

Structurally diverse diterpenoids from the seeds of Caesalpinia minax Hance and their bioactivities.

Eight previously undescribed diterpenoids, caesamins A-H (1-8), were separated and identified from the seeds of Caesalpinia minax Hance. Their structures were characterized by extensive spectroscopic data and X-ray crystallographic analysis. Structurally, caesamin A (1) is the first cassane-type diterpenoid with a C23 carbon skeleton containing an unusual isopropyl.

Anti-pancreatic cancer activity of cassane diterpenoids isolated from the seeds of Caesalpinia sappan mediated by autophagy activation via ROS/AMPK/mTORC1 pathway.

Three undescribed cassane diterpenoids, caesalpanins D-F (1-3), and seven known ones were isolated from the seeds of Caesalpinia sappan. Structures and absolute configurations of 1-3 were elucidated based on the extensive spectroscopic analysis, single-crystal X-ray diffraction analysis, and ECD calculations. Structurally, compound 1 was the first example of 18-norcassane diterpenoid and 2 was a rare 20-norcassane diterpenoid having an unusual five-membered oxygen bridge between C-10/C-18.