Hepatitis C screening and detection program in a large population: Epidemiological transition and characterization of the disease.

Introduction: Chronic hepatitis C (CHC) is considered an important public health challenge. Traditionally identified risk factors have undergone an epidemiological transition where other risk factors have become the main cause of new infections.

Objective: To describe risk factors associated to hepatitis C positivity through the evaluation of the epidemiological profile in hepatitis-C high-risk populations.

Chronic Hepatitis C Treatment with Direct-Acting Antiviral Agents in a Real-Life Setting.

Background: In clinical trials, new oral direct-acting antiviral agent therapies have demonstrated a high sustained virological response rate in patients with hepatitis C virus infection. We aimed to analyze the efficacy and safety data from direct-acting antiviral agent interferon-free therapy in hepatitis C virus infection in a study performed in five different clinical settings in Mexico City; four private practice sites and one academic medical center in a real-world scenario.

Methods: Eighty-one patients were treated with seven different direct-acting antiviral agent regimens, in which the end of treatment, sustained virological response at 12 weeks post-treatment, and adverse effects were evaluated.

[Epidemiologic and situational panorama of hepatitis C in Mexico].

Objective: To determine the epidemiological situation of Chronic Hepatitis C (CHC) in our country.

Background Data: Chronic Hepatitis C affects 170 million people worldwide, and about 0.7% of Mexican population.