Structural characterization of a sulfated polysaccharide from Gracilariadomingensis and potential anti-inflammatory and antinociceptive effects.

Seaweeds are natural sources of sulfated polysaccharides (SPs), biopolymers with remarkable pharmacological properties, including biological actions capable of attenuating components of the inflammatory process such as edema, cytokines, cell migration and pain. Our results confirm that SPs obtained from Gracilaria domingensis (SP-GD) are agarans, primarily composed of residues of β-d-galactopyranose 6-sulfate and 3,6-anhydro-α-l-galactopyranose. Specifically, SP-GD at a dose of 10 mg/kg was effective in significantly reducing paw edema induced by carrageenan or histamine, serotonin, bradykinin, 48/80 and prostaglandin E2.

Study of the antibacterial and cytotoxic activity of chitosan and its derivatives chemically modified with phthalic anhydride and ethylenediamine.

The insertion of hydrophobic and hydrophilic chains in the chitosan molecule can improve its antibacterial activity, expanding its range of application in several areas of medical-pharmaceutical sciences. Thus, this work aimed to increase the antibacterial activity of chitosan through the modification reaction with phthalic anhydride (QF) and subsequent reaction with ethylenediamine (QFE). The chitosan and derivatives obtained were characterized by elemental analysis, C Nuclear Magnetic Resonance (C NMR), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR) and Thermogravimetric Analysis (TG), where it was possible to prove the chemical modification.

Capra hircus outliers markers in Brazil: Searching for genomic regions under the action of natural selection.

Identifying genome regions subject to selection in local breeds of Brazil is an opportunity to elucidate the C. hircus genome plasticity, flowing the colonization history of the country. Using SNP Bead Chip Illumina 50K genotyping of Brazilian Anglo-Nubian (standardized breed) and Marota (local endangered population from the semiarid area of Brazil) to show outliers loci in genome regions subject to selection.

Organic-Inorganic Hybrid Pigments Based on Bentonite: Strategies to Stabilize the Quinoidal Base Form of Anthocyanin.

Anthocyanins are one of the natural pigments that humanity has employed the most and can substitute synthetic food dyes, which are considered toxic. They are responsible for most purple, blue, and red pigment nuances in tubers, fruits, and flowers. However, they have some limitations in light, pH, oxygen, and temperature conditions.

Modification of chicha gum: Antibacterial activity, ex vivo mucoadhesion, antioxidant activity and cellular viability.

The aim of the present work was to modify the exuded gum of Sterculia striata tree by an amination reaction. The viscosity and zero potential of the chicha gum varied as a function of pH. The modification was confirmed by X-ray diffraction (XRD), infrared spectroscopy (FTIR), size exclusion chromatography (SEC), zeta potential, thermogravimetric analysis (TG), and differential scanning calorimetry (DSC).

Amino-Functionalized Titanate Nanotubes: pH and Kinetic Study of a Promising Adsorbent for Acid Dye in Aqueous Solution.

This work reports the functionalization of sodium titanate nanotubes with amine groups obtained from the reaction of titanate nanotubes with [3-(2-Aminoethylamino)propyl]trimethoxysilane, NaTiNT-2NH, and 3-[2-(2-Aminoethylamino)ethylamino]propyltrimethoxysilane, NaTiNT-3NH. It was verified that the crystalline and morphological structures of NaTiNT were preserved after the functionalization, spectroscopies showed that aminosilane interacted covalently with the surface of NaTiNT, and the incorporation of the aminosilane groups on the surface of NaTiNT can be confirmed. The adsorbent matrices NaTiNT-2NH and NaTiNT-3NH were used to remove the anionic dye from remazol blue R (RB) in aqueous medium, and the highest adsorption capacity was around 365.

Application of Water Hyacinth Biomass () as an Adsorbent for Methylene Blue Dye from Aqueous Medium: Kinetic and Isothermal Study.

Water pollution has generated the need to develop technologies to remove industrial pollutants. Adsorption has been recognized as one of the most effective techniques for effluent remediation. In this study, parts (stem and leaves) of a problematic aquatic weed, the water hyacinth (), were separated to produce a bioadsorbent.

Nanocomposite Hydrogel Produced from PEGDA and Laponite for Bone Regeneration.

Herein, a nanocomposite hydrogel was produced using laponite and polyethylene-glycol diacrylate (PEGDA), with or without Irgacure (IG), for application in bone tissue regeneration. The nanocomposites were characterized by X-ray diffraction (XRD), Fourier-Transform infrared spectroscopy (FTIR), and thermal analysis (TG/DTG). The XRD results showed that the crystallographic structure of laponite was preserved in the nanocomposite hydrogels after the incorporation of PEGDA and IG.

Au@Ag bimetallic nanoparticles deposited on palygorskite in the presence of TiO for enhanced photodegradation activity through synergistic effect.

Herbicides are hazardous organic pollutants that contribute to the risk of environmental contamination. The aim of this work was to investigate the synergistic effect of silver (Ag) and gold (Au) bimetallic nanoparticles deposited on palygorskite (PAL) in the presence of TiO for photodegradation of bentazone (BTZ) herbicide under UV light. Ag and Au@Ag nanoparticles exhibited an average size below 75 nm and surface charge values less than - 30 mV.

Constituents of buriti oil ( L.) like inhibitors of the SARS-Coronavirus main peptidase: an investigation by docking and molecular dynamics.

Statistics show alarming numbers of infected and killed in the world, caused by the Covid-19 pandemic, which still doesn't have a specific treatment and effective in combating all efforts to seek treatments and medications against this disease. Natural products are of relevant interest in the search for new drugs. Thus, Buriti oil () is a natural product extracted from the fruit of the palm and is quite common in the legal Amazon region, Brazil.

Kaolinite/cashew gum bionanocomposite for doxazosin incorporation and its release.

Incorporation of drugs in clay minerals has been widely proposed for the controlled-release or increased solubility of drugs. In this context, a bionanocomposite based on kaolinite and cashew gum (Kln/Gum) was synthesized and characterized by X-ray diffraction (XRD), thermal analysis (TG/DTA), and Fourier transform infrared spectroscopy (FTIR). The bionanocomposite was applied to the incorporation and further release of doxazosin mesylate (DB).

Fabrication of Polymeric Microparticles by Electrospray: The Impact of Experimental Parameters.

Microparticles (MPs) with controlled morphologies and sizes have been investigated by several researchers due to their importance in pharmaceutical, ceramic, cosmetic, and food industries to just name a few. In particular, the electrospray (ES) technique has been shown to be a viable alternative for the development of single particles with different dimensions, multiple layers, and varied morphologies. In order to adjust these properties, it is necessary to optimize different experimental parameters, such as polymer solvent, voltage, flow rate (FR), type of collectors, and distance between the collector and needle tip, which will all be highlighted in this review.

Study of interactions between organic contaminants and a new phosphated biopolymer derived from cellulose.

The extensive use of organic molecules (Rhodamine B and Amitriptyline) also has contributed to environmental pollution; adsorption is a relevant method for removal of these contaminants in aqueous media. In this context, the objective of this study was to modify the surface of cellulose (Cel) with phosphoric acid and sodium tripolyphosphate to obtain a biopolymer with incorporated phosphate groups (PCel). The modification was confirmed by X-ray dispersive energy spectroscopy, solid state nuclear magnetic resonance, X-ray diffraction, and thermal analysis.

Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release.

Inorganic matrices and biopolymers have been widely used in pharmaceutical fields. They show properties such as biocompatibility, incorporation capacity, and controlled drug release, which can become more attractive if they are combined to form hybrid materials. This work proposes the synthesis of new drug delivery systems (DDS) based on magnesium phyllosilicate (Talc) obtained by the sol-gel route method, the biopolymer chitosan (Ch), and the inorganic-organic hybrid formed between this matrix (Talc + Ch), obtained using glutaraldehyde as a crosslink agent, and to study their incorporation/release capacity of amiloride as a model drug.

Understanding kinetics and thermodynamics of the interactions between amitriptyline or eosin yellow and aminosilane-modified cellulose.

A new adsorbent matrix (Cel-SiN) for the adsorption of the dye eosin yellow (EY) and the drug amitriptyline (AMI) from aqueous media has been synthesized. The Cel-SiN matrix was obtained via chemical modification of cellulose with (3-aminopropyl)trimethoxysilane. Successful modification was confirmed using Fourier transform infrared (FTIR) and C and Si solid state nuclear magnetic resonance (SSNMR) spectroscopies, thermal analysis (TG/DTG), X-ray diffraction (XRD), and elemental analysis.

Potential of amino-functionalized cellulose as an alternative sorbent intended to remove anionic dyes from aqueous solutions.

Adsorption has been explored to minimize the pollution caused by dyes. This work relates the preparation of diethylenetriamine-modified cellulose (DetaCel) by reacting phthalic anhydride-modified cellulose (PhCel) with diethylenetriamine (Deta). Materials were characterized by Elemental Analysis and results showed a degree of incorporation of 5.

Potential of Cellulose Functionalized with Carboxylic Acid as Biosorbent for the Removal of Cationic Dyes in Aqueous Solution.

In the last decade, adsorption has been used to minimize the pollution caused by dyes, which represents a serious environmental problem. In this context, this work reports the preparation of phthalic anhydride-modified cellulose (PhCel), through the reaction of cellulose (Cel) with phthalic anhydride (Ph). The efficiency of the reaction was observed by elemental analysis, Fourier Transform Infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and thermogravimetry/derivative thermogravimetry (TG/DTG).

Direct Modification of Microcrystalline Cellulose with Ethylenediamine for use as Adsorbent for Removal Amitriptyline Drug from Environment.

Cellulose derivatives have been widely used as adsorbents for the removal of micropollutants such as drugs, dyes, and metals, due to their abundance, low cost and non-contaminating nature. In this context, several studies have been performed searching for new adsorbents (cellulose derivatives) efficient at contaminant removal from aqueous solutions. Thus, a new adsorbent was synthesized by chemical modification of cellulose with ethylenediamine in the absence of solvent and applied to the adsorption of amitriptyline (AMI) in aqueous solution.

Development of new phosphated cellulose for application as an efficient biomaterial for the incorporation/release of amitriptyline.

In the last years has increased the study about the using of natural biopolymers and theirs derivatives in the removal (adsorption/incorporation) of contaminats of medium aqueous, and theirs utilization in the desorption (release) de drugs. However, there not in the literature studies about the utilization of the cellulose and cellulose phosphate in the adsorption (incorporation)/desorption (release) of the drug amitriptyline (AMI). Therefore, in this study was accomplished the synthesized of the phosphated cellulose (PC) through the reaction of pure cellulose (C) with sodium trimetaphosphate (P) under-reflux, for 4h and at 393K.

Phosphated Cellulose as an Efficient Biomaterial for Aqueous Drug Ranitidine Removal.

Crystalline cellulose chemically modified through a reaction with sodium trimetaphosphate (STMP) in an acidic or basic condition yielded Cel-P4 and Cel-P10. These phosphated solids were characterized by elemental analysis, X-ray diffraction (XRD), infrared (IR) spectroscopy, scanning electron microscopy (SEM), nuclear magnetic resonance (NMR) at the solid state for phosphorus nucleus and dispersive X-ray energy. The elemental results demonstrated that the phosphorylation reaction was more efficient in the basic medium, as supported by the amount of phosphorous content.

Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents.

Parkia platycephala Benth. (Leguminosae--Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period.