Association between weather features and symptoms in hand osteoarthritis: Results from the DIGICOD cohort.

Objective: This cross-sectional study aimed to investigate the association between weather and joint symptoms in patients with hand osteoarthritis (HOA).

Design: We used baseline data from the DIGICOD cohort, a monocentric cohort of patients with HOA, and meteorological measurements (temperature, humidity, barometric pressure) in the Paris region during the 72 ​h before inclusion in the cohort. Clinical outcomes were AUSCAN subscores (pain, stiffness, function), spontaneous and pressure tender joint count (TJC), visual analog scale (VAS) score for hand pain during activity and at rest, and the Functional Index for Hand Osteoarthritis score.

Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort.

Background: The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight-bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA.

Methods: Using the DIGICOD cohort, 352 HOA patients (85 ​% women, mean age 66.

Combined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomised, controlled, open-label trial.

Background: Respiratory infection may account for 30% of acute chest syndrome (ACS) aetiologies. However, antimicrobials are routinely prescribed, and de-escalation and/or discontinuation are challenging. Multiplex Polymerase Chain Reaction (mPCR) with an enlarged respiratory panel might support antimicrobial stewardship, and procalcitonin (PCT) measurements help reduce duration of antibiotic therapy.