Publications by authors named "Alexandre Sabate-Elabbadi"
Background: Sepsis is a serious medical condition that causes long-term morbidity and high mortality, annually affecting millions of people worldwide. The COVID-19 pandemic may have impacted its burden. This study aimed to estimate the impact of the COVID-19 pandemic on sepsis incidence, etiology and associated hospitalization costs in metropolitan France.
View Article and Find Full Text PDFCombined use of respiratory multiplex PCR and procalcitonin to reduce antibiotic exposure in sickle-cell adult patients with acute chest syndrome (The ANTIBIO-STA study): a randomised, controlled, open-label trial.
Lancet Reg Health Eur
April 2025
Background: Respiratory infection may account for 30% of acute chest syndrome (ACS) aetiologies. However, antimicrobials are routinely prescribed, and de-escalation and/or discontinuation are challenging. Multiplex Polymerase Chain Reaction (mPCR) with an enlarged respiratory panel might support antimicrobial stewardship, and procalcitonin (PCT) measurements help reduce duration of antibiotic therapy.
View Article and Find Full Text PDFArticle Synopsis
- - The study analyzed the effects of the COVID-19 pandemic and its aftermath on hospital admissions for lower respiratory tract infections (LRTI), focusing specifically on patients with chronic respiratory disease (CRD) over a ten-year period.
- - Data showed a significant drop in LRTI hospitalizations during the early pandemic and post-lockdown periods compared to pre-pandemic averages, with a 43.64% decrease during the early pandemic and 32.97% during the gradual lifting of restrictions.
- - After restrictions were lifted, there was a notable rebound in LRTI admissions that returned to seasonal patterns, indicating that COVID-19 mitigation strategies affected infection rates, particularly in patients with CRD.