Publications by authors named "Romain Manchon"
Aspergillus and Host-Pathogen Interaction: Focus on treatment-relevant aspects.
Clin Microbiol Infect
September 2025
Background: Invasive aspergillosis (IA) remains a major cause of morbidity and mortality in immunocompromised individuals, with an expanding spectrum of at-risk populations, particularly in the intensive care settings. Despite advances in antifungal pharmacotherapy, treatment outcomes remain suboptimal, and the rise of antifungal resistance highlights the need for adjunctive therapy that leverage host immune mechanisms. The pathogenesis of IA is primarily driven by impaired or dysregulated immune responses to Aspergillus species, mainly Aspergillus fumigatus.
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- The European Union includes 30 outermost and overseas countries and territories (OCTs), where renal transplantation is growing, but many patients still seek treatment in continental Europe, necessitating collaborative care.
- Each OCT has its own infectious disease patterns, which are crucial for ensuring effective post-transplant care for kidney transplant recipients (KTRs).
- The paper suggests a practical approach to enhance pre-transplant evaluations and provides region-specific epidemiological data, advocating for more collaborative research among the OCTs to improve care for infected KTRs.
Cryptococcosis Associated With Biologic Therapy: A Narrative Review.
Open Forum Infect Dis
July 2024
is an opportunistic fungal pathogen that can cause disseminated infection with predominant central nervous system involvement in patients with compromised immunity. Biologics are increasingly used in the treatment of neoplasms and autoimmune/inflammatory conditions and the prevention of transplant rejection, which may affect human defense mechanisms against cryptococcosis. In this review, we comprehensively investigate the association between cryptococcosis and various biologics, highlighting their risks of infection, clinical manifestations, and clinical outcomes.
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- - The text discusses a rare human infection caused by aerobic Gram-negative bacilli found in aquatic environments, involving a 53-year-old woman who developed bloodstream infection and meningitis after breast cancer surgery.
- - The diagnosis was confirmed through PCR amplification and sequencing of 16S ribosomal DNA, identifying the bacteria in both blood and cerebrospinal fluid cultures.
- - Treatment for the patient included a 2-week intravenous course of imipenem followed by a 4-week oral regimen of trimethoprim-sulfamethoxazole, which was successful.