Publications by authors named "Robyn Farrell"
Article Synopsis
- This study explores the relationship between exercise impairments and biomarkers in heart failure with preserved ejection fraction (HFpEF), focusing on exercise rather than just resting states.
- A detailed analysis of 277 proteins was conducted on 151 individuals, identifying specific protein signatures linked to different exercise responses, which helps reveal underlying mechanisms of HFpEF.
- The findings suggest that these protein signatures not only highlight potential new therapeutic targets but also offer methods for early risk assessment and prevention of HFpEF.
Background: Whether systemic oxygen levels (SaO) during exercise can provide a window into invasively derived exercise hemodynamic profiles in patients with undifferentiated dyspnea on exertion is unknown.
Methods: We performed cardiopulmonary exercise testing with invasive hemodynamic monitoring and arterial blood gas sampling in individuals referred for dyspnea on exertion. Receiver operator analysis was performed to distinguish heart failure with preserved ejection fraction from pulmonary arterial hypertension.
Objectives: This study aimed to evaluate hemodynamic correlates of inducible blood pressure (BP) pulsatility with exercise in heart failure with preserved ejection fraction (HFpEF), to identify relationships to outcomes, and to compare this with heart failure with reduced ejection fraction (HFrEF).
Background: In HFpEF, determinants and consequences of exercise BP pulsatility are not well understood.
Methods: We measured exercise BP in 146 patients with HFpEF who underwent invasive cardiopulmonary exercise testing.
Arterial Stiffness and Vascular Load in HFpEF: Differences Among Women and Men.
J Card Fail
February 2022
Background: Mechanisms underlying sex differences in heart failure with preserved ejection fraction (HFpEF) are poorly understood. We sought to examine sex differences in measures of arterial stiffness and the association of arterial stiffness measures with left ventricular hemodynamic responses to exercise in men and women.
Methods: We studied 83 men (mean age 62 years) and 107 women (mean age 59 years) with HFpEF who underwent cardiopulmonary exercise testing with invasive hemodynamic monitoring and arterial stiffness measurement (augmentation pressure [AP], augmentation index [AIx], and aortic pulse pressure [AoPP]).
Background: Obesity has multifactorial effects on lung function and exercise capacity. The contributions of obesity-related inflammatory pathways to alterations in lung function remain unclear.
Research Question: To examine the association of obesity-related inflammatory pathways with pulmonary function, exercise capacity, and pulmonary-specific contributors to exercise intolerance.
Background: Arterial stiffness is thought to contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). We sought to examine arterial stiffness in HFpEF and hypertension and investigate associations of arterial and left ventricular hemodynamic responses to exercise.
Methods And Results: A total of 385 symptomatic individuals with an EF of ≥50% underwent upright cardiopulmonary exercise testing with invasive hemodynamic assessment of arterial stiffness and load (aortic augmentation pressure, augmentation index, systemic vascular resistance index, total arterial compliance index, effective arterial elastance index, and pulse pressure amplification) at rest and during incremental exercise.
Background: Ventilatory efficiency (minute ventilation required to eliminate carbon dioxide, VE/VCO2) during exercise potently predicts outcomes in advanced heart failure with reduced ejection fraction, but its prognostic significance for at-risk individuals with preserved left ventricular systolic function is unclear. We aimed to characterize mechanistic determinants and prognostic implications of VE/VCO2 in a single-center dyspneic referral cohort (MGH-ExS [Massachusetts General Hospital Exercise Study]) and in a large sample of community-dwelling participants in the FHS (Framingham Heart Study).
Methods: Maximum incremental cardiopulmonary exercise tests were performed.
Exercise Pulmonary Hypertension Predicts Clinical Outcomes in Patients With Dyspnea on Effort.
J Am Coll Cardiol
January 2020
Article Synopsis
- The study explored the relationships between abnormal pulmonary arterial pressure (PAP) responses during exercise and clinical outcomes in individuals with chronic exertional dyspnea.
- The research included 714 participants, finding that 41% exhibited abnormal PAP/CO slopes correlated with a doubled risk of cardiovascular events or death during a 3.7-year follow-up.
- Results suggest that exercise-induced pulmonary hypertension is a significant predictor of adverse cardiovascular outcomes, indicating that exercise testing may provide valuable insights beyond resting hemodynamic assessments.