Benefits of Cochlear Implantation for Single-Sided Deafness: Data From the House Clinic-University of Southern California-University of California, Los Angeles Clinical Trial.

Objectives: Cochlear implants (CIs) have been shown to benefit patients with single-sided deafness (SSD) in terms of tinnitus reduction, localization, speech understanding, and quality of life (QoL). While previous studies have shown cochlear implantation may benefit SSD patients, it is unclear which point of comparison is most relevant: baseline performance before implantation versus performance with normal-hearing (NH) ear after implantation. In this study, CI outcomes were assessed in SSD patients before and up to 6 mo postactivation.

Initial Results of a Safety and Feasibility Study of Auditory Brainstem Implantation in Congenitally Deaf Children.

Objective: To determine the safety and feasibility of the auditory brainstem implant (ABI) in congenitally deaf children with cochlear aplasia and/or cochlear nerve deficiency.

Study Design: Phase I feasibility clinical trial of surgery in 10 children, ages 2 to 5 years, over a 3-year period.

Setting: Tertiary children's hospital and university-based pediatric speech/language/hearing center.

Is Birdsong More Like Speech or Music?

Music and speech share many acoustic cues but not all are equally important. For example, harmonic pitch is essential for music but not for speech. When birds communicate is their song more like speech or music? A new study contrasting pitch and spectral patterns shows that birds perceive their song more like humans perceive speech.

Auditory implant research at the House Ear Institute 1989-2013.

The House Ear Institute (HEI) had a long and distinguished history of auditory implant innovation and development. Early clinical innovations include being one of the first cochlear implant (CI) centers, being the first center to implant a child with a cochlear implant in the US, developing the auditory brainstem implant, and developing multiple surgical approaches and tools for Otology. This paper reviews the second stage of auditory implant research at House - in-depth basic research on perceptual capabilities and signal processing for both cochlear implants and auditory brainstem implants.

The development of auditory perception in children after auditory brainstem implantation.

Auditory brainstem implants (ABIs) can provide useful auditory perception and language development in deaf children who are not able to use a cochlear implant (CI). We prospectively followed up a consecutive group of 64 deaf children up to 12 years following ABI surgery. The etiology of deafness in these children was: cochlear nerve aplasia in 49, auditory neuropathy in 1, cochlear malformations in 8, bilateral cochlear postmeningitic ossification in 3, neurofibromatosis type 2 in 2, and bilateral cochlear fractures due to a head injury in 1.

Training improves cochlear implant rate discrimination on a psychophysical task.

The purpose of this study was to determine the extent to which cochlear implant (CI) rate discrimination can be improved through training. Six adult CI users took part in a study that included 32 h of training and assessment on rate discrimination measures. Rate difference limens (DLs) were measured from 110 to 3520 Hz in octave steps using 500 ms biphasic pulse trains; the target and standard stimuli were loudness-balanced with the target always at an adaptively lower rate.

Improving speech perception in noise with current focusing in cochlear implant users.

Cochlear implant (CI) users typically have excellent speech recognition in quiet but struggle with understanding speech in noise. It is thought that broad current spread from stimulating electrodes causes adjacent electrodes to activate overlapping populations of neurons which results in interactions across adjacent channels. Current focusing has been studied as a way to reduce spread of excitation, and therefore, reduce channel interactions.

Improving virtual channel discrimination in a multi-channel context.

Improving spectral resolution in cochlear implants is key to improving performance in difficult listening conditions (e.g. speech in noise, music, etc.

Histopathological analysis of a 15-year user of an auditory brainstem implant.

Auditory brainstem implants (ABIs) can provide highly beneficial hearing sensations to individuals deafened by bilateral vestibular schwannomas (neurofibromatosis type 2). Relatively little is known about the status of stimulated neurons after long-term ABI use. Direct examination of the cochlear nuclear complex (CN) of one 5-year ABI user indicated no deleterious effect.

Advances in auditory prostheses.

Purpose Of Review: Auditory prostheses use electric currents on multiple electrodes to stimulate auditory neurons and recreate auditory sensations in deaf people. Cochlear implants have restored hearing in more than 200  000 deaf adults and children to a level that allows most to understand speech. Here we review the reasons underlying these results and describe new directions in restoring hearing to additional patient populations and the design of new devices.

Estimated net saving to society from cochlear implantation in infants: a preliminary analysis.

Objectives/hypothesis: Although it is clear that cochlear implants (CIs) are highly cost-effective in adults and children, the possible additional economic benefit of implantation at younger ages has to be fully established to verify whether the costs and outcomes of CIs differ between infants and older children.

Study Design: Retrospective cohort study.

Methods: Comprehensive data of CI costs were obtained in four groups of children (age 2-11, 12-23, 24-35, and 72-83 months) from parent questionnaires, national healthcare and educational systems, and retail prices for materials used.

Infants versus older children fitted with cochlear implants: performance over 10 years.

Objectives: To investigate the efficacy of cochlear implants (CIs) in infants versus children operated at later age in term of spoken language skills and cognitive performances.

Method: The present prospective cohort study focuses on 19 children fitted with CIs between 2 and 11 months (X=6.4 months; SD=2.

Current focusing sharpens local peaks of excitation in cochlear implant stimulation.

Cochlear implant (CI) users' spectral resolution is limited by the number of implanted electrodes, interactions between the electrodes, and the underlying neural population. Current steering has been proposed to increase the number of spectral channels beyond the number of physical electrodes, however, electric field interactions may limit CI users' access to current-steered virtual channels (VCs). Current focusing (e.

Effect of stimulation rate on cochlear implant users' phoneme, word and sentence recognition in quiet and in noise.

High stimulation rates in cochlear implants (CI) offer better temporal sampling, can induce stochastic-like firing of auditory neurons and can increase the electric dynamic range, all of which could improve CI speech performance. While commercial CI have employed increasingly high stimulation rates, no clear or consistent advantage has been shown for high rates. In this study, speech recognition was acutely measured with experimental processors in 7 CI subjects (Clarion CII users).

Complications in auditory brainstem implant surgery in adults and children.

Objective: Surgery for hearing restoration with auditory brainstem implantation (ABI) in patients with neurofibromatosis type 2 (NF2) is considered safe, as no increase in postoperative complications related to surgery or device implantation has been observed. Over the last 10 years, we have extended the use of ABI to nontumor (NT) adults and children with cochlear or cochlear nerve malfunctions who would not or did not benefit from a cochlear implant (CI). This article examines the complications encountered in ABI surgery in all patient groups.

Melodic contour identification and music perception by cochlear implant users.

Research and outcomes with cochlear implants (CIs) have revealed a dichotomy in the cues necessary for speech and music recognition. CI devices typically transmit 16-22 spectral channels, each modulated slowly in time. This coarse representation provides enough information to support speech understanding in quiet and rhythmic perception in music, but not enough to support speech understanding in noise or melody recognition.

Progress in restoration of hearing with the auditory brainstem implant.

Fifty years ago auditory scientists were very skeptical about the potential of new prosthetic approaches that electrically stimulated the auditory nerve, the cochlear nuclei (CN), and the inferior colliculus (IC). In those decades, the basilar membrane was considered to play a fundamental and irreplaceable role as a fine spectrum analyzer in hearing physiology, and therefore it was thought that electrical stimulation of the auditory system would have never produced functionally useful hearing. Over the last 30 years, cochlear implants (CIs) have improved steadily to the point where the average sentence recognition with modern multichannel devices is better than 90% correct.

Beyond cochlear implants: awakening the deafened brain.

Cochlear implants have provided hearing to more than 120,000 deaf people. Recent surgical developments include direct electrical stimulation of the brain, bilateral implants and implantation in children less than 1 year old. However, research is beginning to refocus on the role of the brain in providing benefits to implant users.

Audiologic outcomes with the penetrating electrode auditory brainstem implant.

Objective: The penetrating electrode auditory brainstem implant (PABI) is an extension of auditory brainstem implant (ABI) technology originally developed for individuals deafened by neurofibromatosis type 2. Whereas the conventional ABI uses surface electrodes on the cochlear nuclei, the PABI uses 8 or 10 penetrating microelectrodes in conjunction with a separate array of 10 or 12 surface electrodes. The goals of the PABI were to use microstimulation to reduce threshold current levels, increase the range of pitch percepts, and improve electrode selectivity and speech recognition.

Auditory brainstem implants.

The development of cochlear implantation has allowed the majority of patients deafened after the development of language to regain significant auditory benefit. In a subset of patients, however, loss of hearing results from destruction of the cochlear nerves, rendering cochlear implantation ineffective. The most common cause of bilateral destruction of the cochlear nerves is neurofibromatosis type 2 (NF2).

Combined effects of frequency compression-expansion and shift on speech recognition.

Objective: To explore combined acute effects of frequency shift and compression-expansion on speech recognition, using noiseband vocoder processing.

Design: Recognition of vowels and consonants, processed with a noiseband vocoder, was measured with five normal-hearing subjects, between the ages of 27 and 35 yr. The speech signal was filtered into 8 or 16 analysis bands and the envelopes were extracted from each band.