Intranasal administration of -derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.

Background/objectives: Although Alzheimer's disease (AD) is the most prevalent dementia in late life, with amyloid beta (Aβ) deposition and neuroinflammation are recognized among its primary pathological features. Currently, there is currently still a lack of effective therapeutic drugs for AD. () is abundant in active ingredients that harbor anti-inflammatory properties in both central nervous system and the periphery.

Posterior cingulate and medial prefrontal excitation-inhibition balance in euthymic bipolar disorder.

Background: Persistent cognitive deficits and functional impairments are associated with bipolar disorder (BD), even during the euthymic phase. The dysfunction of default mode network (DMN) is critical for self-referential and emotional mental processes and is implicated in BD. The current study aims to explore the balance of excitatory and inhibitory neurotransmitters, i.

Mechanism of the Effect of Compound . Oral Liquid in Treating Alcoholic Rat Liver Injury by Metabolomics.

Purpose: Compound Lin oral liquid (CAROL) is often as a hepatoprotective agent. The present study aimed to elucidate the protective mechanism of CAROL against alcoholic liver injury in rats by untargeted metabolomics combined with multivariate statistical analysis.

Methods: An alcoholic liver disease model was established in sprague-dawley (SD) rats by gavage of alcohol, and CAROL treatment was administered.

[Determination of three plant growth regulators in and by three-phase hollow fiber liquid phase microextraction- high performance liquid chromatography].

() and () are precious raw materials for traditional Chinese medicine. The growing demand for and cannot be met by current production techniques. Hence, the widespread artificial cultivation of and using substantial amounts of plant growth regulators (PGRs) has emerged.

Numerical Simulation of the Microscopic Plugging Mechanism and Particle Flow Process of the Microsphere System.

The microsphere system has small initial particle size, excellent swelling performance, simple manufacturing process, and strong plugging ability. It has great application potential in the field of plugging and profile control of deep reservoirs. Microspheres can effectively plug the pores of fractured cores, inhibit the rapid breakthrough process, and improve the sweep efficiency of the injected fluids.

Experimental Study on the Seepage Characteristics of Multilayer Commingled Production and Influencing Factors of the Development Effect in Low-Permeability Tight Sandstone Gas Reservoirs.

For low-permeability tight sandstone gas reservoirs, multilayer commingled production technology is usually adopted by a large number of production wells. This production method can significantly increase the productivity of a single well, thereby improving the efficiency of gas field development. To have a better understanding of the seepage characteristics of multilayer commingled production of the SXM (ShaXiMiao) Formation tight sandstone gas reservoirs, an indoor physical simulation experiment of commingled injection and separate production using double-pipe parallel long cores was designed under influencing factors such as formation pressures, permeability contrast, and water saturations.

Study on Quality Control of Compound (Wall.) Lindl. by Liquid Chromatography-Tandem Mass Spectrometry.

Compound Anoectochilus roxburghii (Wall.) Lindl. (A.

Experimental Analysis and Numerical Simulation of the Stability of Geological Storage of CO: A Case Study of Transforming a Depleted Gas Reservoir into a Carbon Sink Carrier.

Geological storage of CO is one of the most economical, feasible, and effective measures to slow down global warming. In this study, a combined long core model was designed to study the seepage characteristics of supercritical CO displacement. Moreover, the stability of permanent storage of cushion gas layers formed by supercritical CO injection has been systematically studied.

Experimental Study on the Optimization of Multi-level Nano-Microsphere Deep Profile Control in the Process of Gas Injection in Fracture-Type Buried-Hill Reservoirs.

Fracture-type buried-hill reservoirs refer to dual media which have a fast breakthrough speed and a low sweep efficiency in the process of gas injection displacement. In order to overcome this problem, in this paper, a new profile control and oil displacement technology of pre-slug deep plugging by injection of different levels of nano-microspheres and natural gas was proposed. The mercury intrusion experiments were used to compare the fractal characteristics of the pore structures of the matrix and artificial fractured cores in the buried-hill reservoir.

Respiration detection chip with integrated temperature-insensitive MEMS sensors and CMOS signal processing circuits.

An airflow sensing chip, which integrates MEMS sensors with their CMOS signal processing circuits into a single chip, is proposed for respiration detection. Three micro-cantilever-based airflow sensors were designed and fabricated using a 0.35 μm CMOS/MEMS 2P4M mixed-signal polycide process.